Differential effect of nitric oxide synthase inhibition on sigmoid colon longitudinal and circular muscle responses to nicotine and nerve stimulation <i>in vitro</i>

McKirdy, H. C.; Richardson, Christopher A.; Green, John T.; Rhodes, J.; Williams, Geraint T.; Marshall, R. W.

doi:10.1002/bjs.4395

Cited by 16 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In strips of the sigmoid colon obtained from patients with colorectal cancer, responses to NO released by neural stimulation were also greater in circular than in longitudinal muscle (McKirdy et al, 2004). These observations are supported by histological studies on NOS-and NADPH-positive neurons in the porcine intestine (Barbiers et al, 1993).…”

Section: Species and Regional Differences In The Nitrergic Regulationsupporting

confidence: 62%

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Toda

Herman

2005

Pharmacological Reviews

View full text Add to dashboard Cite

Section: Species and Regional Differences In The Nitrergic Regulationsupporting

confidence: 62%

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Toda

Herman

2005

Pharmacological Reviews

View full text Add to dashboard Cite

“…Stimulation with nicotine at 1 μM and above induced relaxation of the longitudinal preparations from the distal colon (Fig. 1A), as in colons from other species including humans (4,9,10,13,14). The nicotine-induced relaxation started within 5 s after treatment, and the character of the response varied depending on the preparation; the responses were transient within 10 s or relatively sustained over 20 s, and maximal relaxation was 5% - 20% in each preparation.…”

Section: Nicotine-induced Relaxation In Longitudinal Preparations Fromentioning

confidence: 75%

“…6B). In the human sigmoid colon, treatment with 10 μM nicotine reduced the tone and amplitude of spontaneous contractions of the circular muscles (13,14), but had no effect on the contraction of longitudinal muscles (14). As discussed below, a functional NO pathway existed in the mouse rectum.…”

Section: Discussionmentioning

confidence: 97%

“…The doses of nicotine chosen were close to plasma concentrations in smokers and were based on previous reports (13,14,23). Stimulation with nicotine at 1 μM and above induced relaxation of the longitudinal preparations from the distal colon (Fig.…”

Section: Nicotine-induced Relaxation In Longitudinal Preparations Fromentioning

confidence: 95%

“…4). In the human sigmoid colon, almost the entire inhibitory effect of nicotine on the ES-induced contraction of circular muscles was mediated through the NO pathway that was inhibited by L-NAME (13,14). The relaxation induced by 10 μM nicotine and by depolarization with high K + was half mediated by the NO pathway in the longitudinal preparations from the canine proximal colon (10).…”

Section: Role Of the No Pathway In Nicotine-induced Relaxationmentioning

confidence: 98%

See 2 more Smart Citations

Nicotine-Induced Neurogenic Relaxation in the Mouse Colon: Changes With Dextran Sodium Sulfate–Induced Colitis

et al. 2009

View full text Add to dashboard Cite

Abstract. Nicotine has been shown to reduce both tone and muscular activity in the human colon by releasing nitric oxide (NO) from nerves. To our knowledge, however, the effect of nicotine on mouse colon has not been elucidated, and the response in tissue from ulcerative colitis (UC) has not been investigated. We examined nicotine-induced responses in colon from control mice and mice with dextran sodium sulfate (DSS)-induced UC. In controls, bath application of nicotine caused a transient relaxation in longitudinal preparations from the transverse and distal colons but not from the rectum. The response was observed in the presence of bethanechol, abolished by treatment with tetrodotoxin and hexamethonium, and mediated partially (>50%) by the NO pathway. In longitudinal preparations of the distal colon from DSStreated mice, spontaneous contractions decreased markedly, and nicotine caused contraction without relaxation in half of the preparations tested. Nicotine-induced relaxation in the presence of bethanechol was significantly decreased in the DSS-treated distal colon without changing bethanechol-induced contractions. These data suggest that 1) responses to nicotine differ dependent on colon regions, 2) DSS treatment predominantly caused nicotine-sensitive neurogenic changes in distal colon, and 3) DSS treatment may reverse the direction of nicotine-evoked responses in the colon, in mice.

show abstract

Nitrergic Inhibitory Component of Rectal Response to Pelvic Nerve Stimulation

Hc¹

2009

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

Differential effect of nitric oxide synthase inhibition on sigmoid colon longitudinal and circular muscle responses to nicotine and nerve stimulation in vitro

Abstract: These findings suggest that nitric oxide release on neural stimulation is greater in circular than in longitudinal muscle.

Cited by 16 publications

References 17 publications

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Nicotine-Induced Neurogenic Relaxation in the Mouse Colon: Changes With Dextran Sodium Sulfate–Induced Colitis

Nitrergic Inhibitory Component of Rectal Response to Pelvic Nerve Stimulation

Contact Info

Product

Resources

About