Differential effect of predictors of bone mineral density and hip geometry in postmenopausal women: a cross-sectional study

Singh, Rekha; Gupta, Sushil K.; Awasthi, Ashish

doi:10.1007/s11657-015-0246-z

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…Thus, bone mass could decrease in association with parity [18]. In a hospital-based cross sectional study from India, parity was negatively correlated with the BMD of neck of the femur, trochanter, lumbar spine, and forearm [6]. In a study from Turkey, low BMD was associated with high parity in postmenopausal women [7].…”

Section: Discussionmentioning

confidence: 99%

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

Yang

et al. 2020

Endocr J

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This study aimed to investigate the association between parity and bone mineral density in postmenopausal Chinese women, as well as the interference of physical activity and sedentary time on this association. A total of 1,712 participants were enrolled in this study. Participants were separated into three groups according to the number of parities: group 1, 1-2; group 2, 3-4; group 3, ≥5. Physical activity level was assessed according to the International Physical Activity Questionnaire. Calcaneus bone mineral density (BMD) and bone quality were assessed by qualitative ultrasound. As a result, logistic regression showed that compared to that in group 1, the risk of fracture in group 3 was increased significantly (p < 0.001). A greater number of parities was associated with a lower BMD, broadband ultrasonic attenuation (BUA), quantitative ultrasound index (QUI), speed of sound (SOS), and T-score among the three groups after adjustment for age (All p for trend < 0.05). The number of parities was an independent factor negatively correlated with BMD, BUA, QUI, SOS and T-score (All p < 0.05). BMD, BUA, QUI, SOS, and T-score were significantly increased in the physically a participants independent of parity (all p < 0.05), and decreased in the sedentary participants independent of parity (p < 0.05, except BUA). A great number of parities was negatively associated with bone health. Physical activity was positively correlated and sedentary time was negatively correlated with bone health independent of parity.

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Section: Discussionmentioning

confidence: 99%

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

Yang

et al. 2020

Endocr J

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“…The mechanical stress within a cross-section subjected to bending is inversely related to the CSMI. It varies with the distance from the neutral axis [ 25 , 26 ]. In other words, basicervical fractures have a lower bending strength than femoral neck fractures, which occur near the intertrochanteric line.…”

Section: Discussionmentioning

confidence: 99%

Comparison of hip structure analysis and grip strength between femoral neck and basicervical fractures

Cha

Yoo

2021

BMC Musculoskelet Disord

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Background The purpose of this study was to analyze differences in geometrical properties of the proximal femur and predict the occurrence of basicervical fractures through a comparative study of femoral neck and basicervical fractures in patients undergoing hip structural analysis (HSA). Methods All patients with hip fractures who were at least 65 years old and admitted to our hospital between March 2017 and December 2019 were eligible for this study. During the study period, 149 femur neck fractures (FNF) and basicervical fractures (intertrochanteric fractures of A31.2) were included in this study. Fifty-nine patients were included in the final analysis. Factors considered to be important confounders affecting the occurrence of basicervical hip fractures were chosen for propensity-score analysis. A logistic model with basicervical hip fracture as the outcome and age, sex, weight, spinal T-score, hip T-score, and vitamin D levels as confounders was used to estimate the propensity score. Results The cross-sectional moment of inertia (CSMI) of the intertrochanter was significantly lower in patients with basicervical hip fracture (HF) than in patients with FNF (p = 0.045). However, there was no significant differences in any other HSA variable between the two groups. Receiver operating characteristic (ROC) analysis showed that cutoff point for HSA was 100 for hip axis length (HAL) (AUC = 0.659, p < 0.001) and 5.712 for CSMI of the intertrochanter (AUC = 0.676, p < 0.001). ROC analysis showed that cutoff points of HAL, CSMI of intertrochanter, and handgrip strength were 104.8, 8.75, and 16.9, respectively (AUC = 0.726, p < 0.001). Conclusions Proximal femoral geometric analysis using HSA is a useful method for predicting the type of hip fracture. Additionally, a lower CSMI, a shorter HAL, and a lower grip strength are major predictors of basicervical fractures.

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“…The CSMI is used to measure the distribution of material around the neck axis necessary to calculate the resistance to bending. The mechanical stress within a cross-section subjected to bending is inversely related to the CSMI and varies with the distance from the neutral axis [20,21]. In other words, basicervical fractures have a lower bending strength compared to femoral neck fractures, which occurs near the intertrochanteric line.…”

Section: Discussionmentioning

confidence: 99%

Comparison of hip structure analysis and grip strength between femoral neck and basicervical fractures

Cha

Yoo

2021

Preprint

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Background: The purpose of this study was to analyze differences in the geometrical properties of the proximal femur and predict the occurrence of basicervical fractures through a comparative study of femoral neck and basicervical fractures in patients undergoing hip structural analysis (HSA). Methods: All patients with hip fractures who were at least 65 years old and admitted to our hospital between March 2017 and December 2019 were eligible for this study. During the study period, 149 femur neck fractures (FNF) and basicervical fractures (intertrochanteric fractures of A31.2) were included in the study. Fifty-nine people were included in the final analysis. The factors considered to be the most important confounders affecting the occurrence of basicervical hip fractures were chosen for propensity-score analysis. A logistic model with basicervical hip fractures as the outcome and age, sex, weight, spinal T-score, hip T-score, and vitamin D levels as confounders was used to estimate the propensity score.Results: The cross-sectional moment of inertia (CSMI) of the intertrochanter was significantly lower in the basicervical hip fracture (HF) patients than in the FNF patients (p = 0.045). However, there were no significant differences in any other HSA variable between the two groups. The results of ROC analysis showed that the cutoff points for HSA were 100 in hip axis length (HAL) (AUC = 0.659, p < 0.001) and 5.712 in the CSMI of the intertrochanter (AUC = 0.676, p < 0.001). After considering three variables, including HAL, the CSMI of intertrochanter, and handgrip strength, the results of the receiver operating characteristic (ROC) analysis were 104.8, 8.75, and 16.9 (AUC = 0.726, p < 0.001), respectively.Conclusions: Proximal femoral geometric analysis using HSA is a useful method for predicting the type of hip fracture. Additionally, a lower CSMI, shorter HAL, and lower grip strength are major predictors of basicervical fractures.

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Differential effect of predictors of bone mineral density and hip geometry in postmenopausal women: a cross-sectional study

Abstract: MD, LD, parity, BMI, and age are important factors influencing BMD at hip and spine in postmenopausal women, and have site-specific effects on BMD.

Cited by 9 publications

References 27 publications

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

Comparison of hip structure analysis and grip strength between femoral neck and basicervical fractures

Comparison of hip structure analysis and grip strength between femoral neck and basicervical fractures

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