2005
DOI: 10.1016/j.neurobiolaging.2004.06.004
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Differential effect of retinoic acid and triiodothyronine on the age-related hypo-expression of neurogranin in rat

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Cited by 31 publications
(27 citation statements)
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“…The rats were allowed to recover from the anesthesia before returning to their cages with free access to food and water. Twelve hours before distal MCAO, the vehicle (polyethylene glycol, NaCl and ethanol (70/20/10)) or retinoic acid (150 µg RA/kg body weight) (12,13) were intraperitoneally injected in the latter two groups, and after the distal MCAO was performed, intraperitoneal injections were administered daily until the animals were sacrificed. RA (all-trans RA; Sigma, USA, No.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The rats were allowed to recover from the anesthesia before returning to their cages with free access to food and water. Twelve hours before distal MCAO, the vehicle (polyethylene glycol, NaCl and ethanol (70/20/10)) or retinoic acid (150 µg RA/kg body weight) (12,13) were intraperitoneally injected in the latter two groups, and after the distal MCAO was performed, intraperitoneal injections were administered daily until the animals were sacrificed. RA (all-trans RA; Sigma, USA, No.…”
Section: Methodsmentioning
confidence: 99%
“…RA (all-trans RA; Sigma, USA, No. R2625) was dissolved in a mixture containing polyethylene glycol, NaCl and ethanol (70/20/10) (12,13). …”
Section: Methodsmentioning
confidence: 99%
“…Il en resulte une diminution de la biodisponibilite cellulaire en acide retinoïque qui se traduit chez l'animal age, dans plusieurs tissus cibles (foie, cerveau) par une baisse d'activite de la voie de signalisation des retinoïdes Pallet et al, 1997). Cette baisse d'activite des retinoïdes, dans les tissus cibles, a egalement ete mise en evidence chez l'hommeâge (Feart et al, 2005).…”
Section: Vitamine a Et Vieillissement Cerebralunclassified
“…It is now established that retinoids are required for cognitive functions in the adulthood [4], [5], [6], [7] and that retinoid hyposignalling contributes to the deterioration of hippocampal synaptic plasticity and functions [8], [9], [10]. In aged rodents, the naturally occurring hypoactivity of the retinoid signalling pathway has been associated with the reduction of hippocampal synaptic plasticity [11], [12], known to underlie at least in part relational memory processing [13], [14]. Indeed, pharmacological activation of retinoid signalling by short-term RA treatment in aged mice restored their impaired hippocampal long-term potentiation as well as their long-term relational memory deficits [7].…”
Section: Introductionmentioning
confidence: 99%
“…Vitamin A and its derivatives, as RA, act on memory processes by modulating different aspects of hippocampal plasticity including synaptic plasticity [7], [12] but also adult neurogenesis in the dentate gyrus (DG) [35], [36], [37], [38]. Indeed, it has recently been demonstrated that RA treatment can restore normal level of neurogenesis in vitamin A deficient rats [36].…”
Section: Introductionmentioning
confidence: 99%