Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress

Rosas-Villegas, Adriana; Sánchez‐Tapia, Mónica; Ávila-Nava, Azalia; Ramírez, V Mercy; Tovar, Armando R.; Torres, Nimbe

doi:10.3390/nu9040393

Cited by 81 publications

(70 citation statements)

References 38 publications

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“…People eating more fiber and vegetables get fewer GI diseases, while diets high in sugar, salt and fat have been clearly considered to be the GI diseases generator [1,2]. Sodium chloride from dietary salt provides essential electrolytes to the human body and plays a vital role in maintaining the stability of the intracellular and extracellular environments.…”

Section: Introductionmentioning

confidence: 99%

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

Sun

Guo

et al. 2018

Digestion

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Background: Gastrointestinal (GI) diseases are known to be largely influenced by one’s lifestyle and dietary uptake. A high-salt diet (HSD) is well recognized as a risk factor for cardiovascular complications, hypertension, and metabolic syndromes. However, the relationship between an HSD and the GI system, which is the compartment that comes in direct contact with exogenous stimulants, has not been fully explored. Aims: We seek to better understand the complexity of the pathogenic effects of an HSD in the context of GI disorders. Methods: By searching the PubMed and Web of science, the review of literature was performed using keywords: high-salt and GI, high-salt and immunity, salt and microbiota, salt and hormone. Results: In this review, we concluded that high-salt intake potentially perturbs the local immune homeostasis, alters the gut microbiota composition and function, and affects the endocrine hormone profiling in the GI system. Conclusion: HSD might get involved in GI diseases through the reshaping of gastroenterological milieu, which could help to better understand the complexity of the pathogenic effects of an HSD in the context of GI disorders.

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Section: Introductionmentioning

confidence: 99%

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

Sun

Guo

et al. 2018

Digestion

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“…Alpha diversity was also affected by VSG, but to a lesser degree than by the change of diet, although VSG only removes the glandular part of the stomach and leaves the intestine intact [28]. Nonetheless, both C and D groups subjected to VSG had reduced alpha diversity, similar to what has been seen in humans and animals [41,42], but also to Sham surgery, suggesting the effects of the antibiotic Enrofloxacina were the primary cause rather than the surgery itself. Interestingly, the combination of antibiotic and diet change increased alpha diversity for D + C-Sham and D + C-VSG.…”

Section: Discussionmentioning

confidence: 59%

Diet change affects intestinal microbiota restoration and improves vertical sleeve gastrectomy outcome in diet-induced obese rats

et al. 2020

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Purpose Obesity, a worldwide health problem, is linked to an abnormal gut microbiota and is currently most effectively treated by bariatric surgery. Our aim was to characterize the microbiota of high-fat fed Sprague-Dawley rats when subjected to bariatric surgery (i.e., vertical sleeve gastrectomy) and posterior refeeding with either a high-fat or control diet. We hypothesized that bariatric surgery followed by the control diet was more effective in reverting the microbiota modifications caused by the high-fat diet when compared to either of the two factors alone. Methods Using next-generation sequencing of ribosomal RNA amplicons, we analyzed and compared the composition of the cecal microbiota after vertical sleeve gastrectomy with control groups representing non-operated rats, control fed, high-fat fed, and post-operative diet-switched animals. Rats were fed either a high-fat or control low-fat diet and were separated into three comparison groups after eight weeks comprising no surgery, sham surgery, and vertical sleeve gastrectomy. Half of the rats were then moved from the HFD to the control diet. Using next-generation sequencing of ribosomal RNA amplicons, we analyzed the composition of the cecal microbiota of rats allocated to the vertical sleeve gastrectomy group and compared it to that of the non-surgical, control fed, high-fat fed, and post-operative diet-switched groups. Additionally, we correlated different biological parameters with the genera exhibiting the highest variation in abundance between the groups. Results The high-fat diet was the strongest driver of altered taxonomic composition, relative microbial abundance, and diversity in the cecum. These effects were partially reversed in the diet-switched cohort, especially when combined with sleeve gastrectomy, resulting in increased diversity and shifting relative abundances. Several highly-affected genera were correlated with obesity-related parameters. Conclusions The dysbiotic state caused by high-fat diet was improved by the change to the lower fat, higher fiber control diet. Bariatric surgery contributed significantly and additively to the diet in restoring microbiome diversity and complexity. These results highlight the importance of dietary intervention following bariatric surgery for improved restoration of cecal diversity, as neither surgery nor change of diet alone had the same effects as when combined. KeywordsBariatric surgery · High-fat diet · Rat models · Microbiota Abbreviations SCD Standard chow diet HFD High-fat diet D Diet induced obesity BS Bariatric surgery VSG Vertical sleeve gastrectomy NS No surgery * Klas I. Udekwu

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“…The composition of gut microbiome of Lactobacillus and FOS probiotic mixture treatment group was much more diverse than that of the natural recovery group, indicating a better recovery effect of the probiotic cocktails on the gut microbiome (Shi et al, 2017). Moreover, the composition of the gut microbiome significantly changed in the HFD + fructose (HFF)-fed and the HFD + sucrose (HFS)-fed rats compared with the control diet (C)-fed rats; body-fat mass, metabolic inflexibility, glucose intolerance, lipopolysaccharide (LPS), insulin, renal reactive oxygen species (ROS), malondialdehyde (MDA), Nadphox, and Srebp-1 were significantly higher, and antioxidant enzymes and lean body masses were significantly lower in the HFS group with respect for the HFF group (Rosas-Villegas et al, 2017), indicating the harmful effect on the HFS group and the HFF group on gut microbiome as well as the health of humans. Carrageenan, agarose, and alginate are algae-derived undigested polysaccharides that have been used as food additives for hundreds of years.…”

Section: Close Relationships Among Diet Gut Microbiome and Health Carementioning

confidence: 99%

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

et al. 2020

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Advances in systems biology, particularly based on the omics approaches, have resulted in a paradigm shift in both traditional Chinese medicine (TCM) and the gut microbiome research. In line with this paradigm shift, the importance of TCM and gut microbiome in healthcare, as well as their interplay, has become clearer. Firstly, we briefly summarize the current status of three topics in this review: microbiome, TCM, and relationship of TCM and microbiome. Second, we focused on TCM's therapeutic effects and gut microbiome's mediation roles, including the relationships among diet, gut microbiome, and health care. Third, we have summarized some databases and tools to help understand the impact of TCM and gut microbiome on diagnosis and treatment at the molecular level. Finally, we introduce the effects of gut microbiome on TCM and host health, with two case studies, one on the metabolic effect of gut microbiome on TCM, and another on cancer treatment. In summary, we have reviewed the current status of the two components of healthcare: TCM and gut microbiome, as well as their concert effects. It is quite clear that as the holobiont, the maintenance of the health status of human would depend heavily on TCM, gut microbiome, and their combined effects.

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Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress

Cited by 81 publications

References 38 publications

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

Diet change affects intestinal microbiota restoration and improves vertical sleeve gastrectomy outcome in diet-induced obese rats

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

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