Differential effect of vasopressin on angiotensin and norepinephrine pressor action in rats

Elijovich, Fernando; Barry, Cathy; Krakoff, L. R.; Kirchberger, Madeleine A.

doi:10.1152/ajpheart.1984.247.6.h973

Cited by 4 publications

(2 citation statements)

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“…Arginine vasopressin was initially reported to enhance the pressor activity of NA both in pithed rats and on isolated aortic strips [4]. However, in conscious rats AVP slightly diminishes the pressor effect of NA [5] whilst NA appears to desensitize aortic strips to AVP [6]. Furthermore, AVP-deficient Brattleboro rats also appear to be more sensitive than normal rats to i.v.…”

Section: Discussionmentioning

confidence: 99%

“…These disorders may be direct consequences of the absence of the central, neuromodulatory influences of AVP [3]. There is also evidence that exogenous AVP may influence the pressor actions of noradrenaline (NA) angiotensin I1 (AII) [5,7]. Brattleboro rats have also been shown to have increased sensitivity to the pressor effects of AVP given by either bolus injection or infusion [8,9], possibly as a result of up-regulation of AVP vascular receptors due to chronic AVP deficiency.…”

Section: Introductionmentioning

confidence: 99%

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Increased sensitivity to pressor hormones in central diabetes insipidus

Williams

Laycock

Lightman

et al. 1988

Eur J Clin Investigation

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Abstract. Pressor sensitivities to infusions of arginine vasopressin (AVP), noradrenaline (NA) and angiotensin I1 (AII), as well as cardiovascular responses to head-up tilt, were assessed in subjects with central diabetes insipidus (CDI) and compared with those in normal control subjects. During incremental i.v. infusions of AVP at 0.2-5.0 pmol min-' kg-', mean arterial blood pressure (MABP) rose progressively in CDI subjects only and the rise was significantly greater than that which occurred in control subjects during their final infusion. The pressor effects of incremental i.v. infusions of NA and A11 were greater, and the bradycardia associated with NA was more pronounced, in CDI subjects than in controls. Whole body tilt from supine to 45" head-up was associated with increased heart rate and an insignificant rise in MABP in both groups, although a rise in plasma AVP occurred in control subjects only. These results demonstrate that subjects with CDI are more sensitive than control subjects to the pressor effects of NA and AII, and also develop sensitivity to the pressor effects of AVP. Their cardiovascular responses to head-up tilt remain intact. Presumably the increased vascular sensitivity to NA and A11 in subjects with CDI is sufficient to compensate for their lack of AVP response during head-up tilt.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased sensitivity to pressor hormones in central diabetes insipidus

Williams

Laycock

Lightman

et al. 1988

Eur J Clin Investigation

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The Role of Vasopressin in Experimental and Clinical Hypertension

Krakoff

Elijovich

Barry

1985

American Journal of Kidney Diseases

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Are hypertensive effects of aldosterone, angiotensin, vasopressin, and norepinephrine chronically additive?

Cowley¹,

Skelton²,

Merrill³

1986

Hypertension

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SUMMARY The effects of chronic combined administration of angiotensin II, norepinephrine, aldosterone, and arginine vasopressin were compared with the response to each of these hormones administered alone. The studies were performed in dogs to determine the extent to which moderately inappropriate elevations of these hormones could enhance each other's ability to produce chronic hypertension and influence Na and water homeostasis. Blood pressure sensitivity to Na intake was also evaluated by infusing the hormones for 11 days at normal levels of Na intake followed by 11 days at high Na intake with ad libitum drinking. Combined hormone administration did not enhance each hormone's singular hypertensive actions. With aldosterone infusion alone and normal Na intake, mean arterial pressure rose nearly IS mm Hg and an additional 3 mm Hg during high Na intake. Combined hormone infusion also resulted in a nearly 15 mm Hg rise during normal Na intake and an additional 3 mm Hg rise in mean arterial pressure during high Na intake. Marked Na retention and hypernatremia were observed with aldosterone infusion, while hyponatremia characterized arginine vasopressin infusion. The combined hormone infusion resulted in a tendency toward hypernatremia, although dairy Na balance was not significantly changed. Dairy water turnover was substantially increased and urine osmolality fell to hypoosmotic levels, despite elevated arginine vasopressin levels. Even with high Na intake, dogs receiving either angiotensin II, arginine vasopressin, or norepinephrine at the same concentrations showed 4 to 10 mm Hg increases in mean arterial pressure. Thus, humoral summation or synergism of these hormones probably does not play a major role in the development of chronic hypertension. 1 " 7 The importance of these neuroendocrine changes remains largely uncertain, however, since reported plasma hormone levels generally have been less than those required to produce hypertension experimentally.

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Differential effect of vasopressin on angiotensin and norepinephrine pressor action in rats

Cited by 4 publications

References 0 publications

Increased sensitivity to pressor hormones in central diabetes insipidus

Increased sensitivity to pressor hormones in central diabetes insipidus

The Role of Vasopressin in Experimental and Clinical Hypertension

Are hypertensive effects of aldosterone, angiotensin, vasopressin, and norepinephrine chronically additive?

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