2016
DOI: 10.5487/tr.2016.32.4.353
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Differential Effects between Cigarette Total Particulate Matter and Cigarette Smoke Extract on Blood and Blood Vessel

Abstract: The generation and collection of cigarette smoke (CS) is a prerequisite for any toxicology study on smoking, especially an in vitro CS exposure study. In this study, the effects on blood and vascular function were tested with two widely used CS preparations to compare the biological effects of CS with respect to the CS preparation used. CS was prepared in the form of total particulate matter (TPM), which is CS trapped in a Cambridge filter pad, and cigarette smoke extract (CSE), which is CS trapped in phosphat… Show more

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Cited by 6 publications
(5 citation statements)
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“…Park JM's study proposed that cigarette smoke extract (CSE) inhibited thrombin-induced platelet aggregation. 36 Since the toxic substances in cigarette smoke disturb the internal environment of the body, disrupting homeostasis, and since long-term smoking causes inflammatory reactions in the lungs and even the whole body. 27,32 These reactions trigger oxidative stress, releasing large amounts of reactive oxygen species (ROS), which also include oxidants produced by inflammation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Park JM's study proposed that cigarette smoke extract (CSE) inhibited thrombin-induced platelet aggregation. 36 Since the toxic substances in cigarette smoke disturb the internal environment of the body, disrupting homeostasis, and since long-term smoking causes inflammatory reactions in the lungs and even the whole body. 27,32 These reactions trigger oxidative stress, releasing large amounts of reactive oxygen species (ROS), which also include oxidants produced by inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…These oxidative stress processes modulate platelet function and alter coagulation. 36 However, the role of coagulation deficits in the development and progression of PH has not yet been elucidated, and whether smoking causes group 3 PH coagulopathy and thus promotes the development of PH requires further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Erythrocyte suspension was prepared and hemolysis was assessed as previously described (14). Briefly, blood was withdrawn from the abdominal aorta of ether-anesthetized rats and subjected to centrifugation at 1,000 g for 10 min.…”
Section: Methodsmentioning
confidence: 99%
“…To confirm the elucidative mechanisms by which Enterococcus Faecalis exerts these effects, the number of leukocyte and lymphocyte was monitored as a hemopoietic action. Furthermore, NK and LAK activity were measured as immunological parameters ( 9 – 11 ).…”
Section: Introductionmentioning
confidence: 99%