Differential Effects of 25-Hydroxyvitamin D3 versus 1α 25-Dihydroxyvitamin D3 on Adipose Tissue Browning in CKD-Associated Cachexia

Mak, Robert H.; Querfeld, Uwe; Gonzalez, Alex; Gunta, Sujana S.; Cheung, Wai W.

doi:10.3390/cells10123382

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…Vitamin D promotes myogenesis and improves muscle contractility by activating the calcium-binding protein (calbindin-D9K), MAP kinase (MAPK), and phospholipase C (PLC) signaling cascade, which promote calcium influx into myocytes. Additionally, vitamin D improves energy homeostasis, reduces inflammation and intramuscular fatty infiltration, and increases muscle mass volume by reversing adipose browning [32]. Subjects with hypovitaminosis D often have difficulties in maintaining gait balance, leading to a higher chance of falls and associated injuries [33].…”

Section: Discussionmentioning

confidence: 99%

“…Subjects with hypovitaminosis D often have difficulties in maintaining gait balance, leading to a higher chance of falls and associated injuries [33]. Multiple studies in animal models have demonstrated the effects of exogenous vitamin D therapy in attenuating protein energy wasting and improving muscle mass and function [32]. Observational studies have also shown that HD patients with vitamin D supplementation have better nutrition, less inflammation, and a lower fracture rate [34,35].…”

Section: Discussionmentioning

confidence: 99%

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Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Chan,

Ng,

Cheng

et al. 2023

Nutrients

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Background: The relationship between dietary patterns and the malnutrition–inflammation–frailty complex in patients undergoing peritoneal dialysis (PD) is currently unknown. Our objective was to measure dietary nutrient intake and evaluate its association with malnutrition, inflammation, and frailty. Methods: We prospectively recruited adult PD patients. We assessed their dietary nutrient intake using a food frequency questionnaire. Frailty, malnutrition, and inflammation were evaluated by validated Frailty Score (FQ), Subjective Global Assessment (SGA), and Malnutrition-Inflammation Score (MIS). Results: A total of 209 patients were recruited for the study. Among them, 89 patients (42.6%) had an insufficient protein intake, and 104 patients (49.8%) had an insufficient energy intake. Additionally, 127 subjects were identified as frail, characterized by being older (61.9 ± 9.5 vs. 55.6 ± 12.8, p < 0.001), malnourished (SGA: 21.0 ± 2.7 vs. 22.7 ± 3.1, p < 0.001), and having a high inflammation burden (MIS: 10.55 ± 3.72 vs. 7.18 ± 3.61, p < 0.001). There was a significant correlation between dietary zinc intake and body mass index (r = 0.31, p < 0.001), SGA (r = 0.22, p = 0.01), and MIS (r = −0.22, p = 0.01). In the multivariate model, a higher dietary zinc intake predicted a higher SGA (beta 0.03, p = 0.003) and lower FQ (beta −0.38, p < 0.001) and MIS (beta −0.14, p < 0.001), indicating a better nutrition, less frail and inflamed state. A higher dietary zinc intake was also associated with a lower odds of being frail (adjusted odds ratio 0.96, p = 0.009). Conclusion: Dietary inadequacy and micronutrient deficiency are common among the PD population. Dietary zinc intake is independently associated with an improved nutrition, physical condition, and reduced inflammatory state.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Chan,

Ng,

Cheng

et al. 2023

Nutrients

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“…[ 11 ] Further, there is evolving evidence to suggest that specific biomarkers like leptin, 25 hydroxyvitamin D levels, and interleukin -1 play a specific role in CKD-related cachexia. [ 12 13 14 ] In pursuit of developing an inclusive criterion reflective of the complex interplay of nutrition and inflammation, the PEW criterion was proposed for adults. Thereafter, the criterion was adapted for use in children with CKD.…”

Section: Discussionmentioning

confidence: 99%

Nutrition-focused physical examination for detecting protein energy wasting in children with chronic kidney disease

Iyengar,

Collins,

Ashok

et al. 2023

Indian J Nephrol

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Introduction: There is a need to explore less laborious point-of-care assessment tools to diagnose protein energy wasting (PEW) in children with chronic kidney disease (CKD). This cross-sectional study was undertaken to assess the profile of specific nutrition-focused physical examination (NFPE) and mid-arm muscle area (MAMA) in children with CKD and determine their role in the diagnosis of PEW. Methods: PEW criterion was applied to all eligible children and MAMA was derived from mid-arm circumference and triceps skin fold thickness. NFPE signs examined were muscle wasting (MW) and subcutaneous fat loss (FL). Results: One hundred and twenty-six children with CKD (86 in CKD stages 2–4 and 40 on dialysis) were studied. PEW was prevalent in 41.8% children with CKD2-4 and in 72.5% on dialysis. In children with CKD 2–4, low MAMA, MW, and FL were significantly associated with PEW with an odd’s ratio of 5.3 (1.55,18.30), 10.6 (3.8,29.8), and 10.5 (3.7,29.2) respectively (P = <0.001). Similarly, in children on dialysis, low MAMA, MW, and FL were more likely to be associated with PEW with an odd’s ratio of 17 (2.2,127.7); P = 0.017, 16.6 (3,90.8); P = 0.001 and 19 (2.1,170.3); and P = 0.009, respectively. MW demonstrated high sensitivity and specificity [80.6 and 72%, respectively, with a positive predictive value (PPV) of 67.4%] to diagnose PEW in the CKD 2-4 group and in those on dialysis [86.2 and 72.1%, respectively, with PPV of 89.3%]. Conclusion: Clinical signs based on NFPE are useful in detecting PEW in children with CKD2-4 and in those on dialysis.

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“…Interestingly, proteomic analyses revealed the upregulation of VDBP in biological fluids from patients or animal models affected by pathologies susceptible to progressive muscle wasting or cachexia, including several types of cancer [7][8][9][10][11][12] , chronic kidney disease 13 , diabetes mellitus 14 , multiple sclerosis 15 , Parkinson's disease 16 , and COPD 17 , suggesting a potential role for VDBP in skeletal muscle homeostasis. We specifically hypothesized that VDBP could induce muscle atrophy and participate in cancer-associated muscle wasting.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting

Filigheddu,

Raiteri,

Reano

et al. 2024

Preprint

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The maintenance of skeletal muscle is of pivotal importance, as its loss is often associated with progressive pathologies, generally worsening the prognosis. Increased levels of vitamin D binding protein (VDBP) were reported in diseases susceptible to muscle wasting, including several tumors. We hypothesized that VDBP might participate in muscle wasting and investigated its direct effects on skeletal muscle homeostasis. Here we demonstrate that VDBP induces atrophy independently of vitamin D. In C2C12 myotubes, we identified intracellular actin dynamics perturbation and subsequent mitochondrial dysfunction as the main molecular mechanisms of VDBP-induced atrophy. Coherently, the ectopic introduction of VDBP in mice lacking the protein (Gc-knockout mice) induced muscle atrophy and decreased strength. Finally, we present proof-of-concept evidence that VDBP contributes to cancer-associated muscle wasting. Altogether, these findings provide novel insights into the biological function of VDBP as a pro-atrophic hormone with potential implications for the treatment of muscle wasting.

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Differential Effects of 25-Hydroxyvitamin D3 versus 1α 25-Dihydroxyvitamin D3 on Adipose Tissue Browning in CKD-Associated Cachexia

Cited by 5 publications

References 64 publications

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Nutrition-focused physical examination for detecting protein energy wasting in children with chronic kidney disease

Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting

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