Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement

Rosas‐González, Vida Celeste; Téllez‐Bañuelos, Martha Cecilia; Hernández‐Flores, Georgina; Bravo-Cuéllar, Alejandro; Aguilar‐Lemarroy, Adriana; Jave‐Suárez, Luis Felipe; Haramati, Jesse; Solorzano‐Ibarra, Fabiola; Ortiz‐Lazareno, Pablo César

doi:10.1111/fcp.12559

Cited by 27 publications

(12 citation statements)

References 40 publications

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“…The antitumoral effect of garlic induced by its bioactive sulfur compounds like allicin, diallyl-sulfides (DAS), diallyl-disulfides (DADS), and diallyl-trisulfides (DATS), raises interest for many studies [ 11 , 12 , 13 ]. DATS can stimulate cytotoxicity by targeting reactive oxygen species (ROS) and can activate the ROS dependent caspase pathway, therefore it can promote apoptosis [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

et al. 2021

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Allium sativum L. (garlic bulbs) and Allium fistulosum L. (Welsh onion leaves) showed quantitative differences of identified compounds: allicin and alliin (380 µg/mL and 1410 µg/mL in garlic; 20 µg/mL and 145 µg/mL in Welsh onion), and the phenolic compounds (chlorogenic acid, p-coumaric acid, ferulic acid, gentisic acid, 4-hydroxybenzoic acid, kaempferol, isoquercitrin, quercitrin, quercetin, and rutin). The chemical composition determined the inhibitory activity of Allium extracts in a dose-dependent manner, on human normal cells (BJ-IC50 0.8841% garlic/0.2433% Welsh onion and HaCaT-IC50 1.086% garlic/0.6197% Welsh onion) and tumor cells (DLD-1-IC50 5.482%/2.124%; MDA-MB-231-IC50 6.375%/2.464%; MCF-7-IC50 6.131%/3.353%; and SK-MES-1-IC50 4.651%/5.819%). At high concentrations, the cytotoxic activity of each extract, on normal cells, was confirmed by: the 50% of the growth inhibition concentration (IC50) value, the cell death induced by necrosis, and biochemical determination of LDH, catalase, and Caspase-3. The four tumor cell lines treated with high concentrations (10%, 5%, 2.5%, and 1.25%) of garlic extract showed different sensibility, appreciated on the base of IC50 value for the most sensitive cell line (SK-MES-1), and the less sensitive (MDA-MB-231) cell line. The high concentrations of Welsh onion extract (5%, 2.5%, and 1.25%) induced pH changes in the culture medium and SK-MES-1 being the less sensitive cell line.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

et al. 2021

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“…In addition, allicin reduced cell viability and induced apoptosis by triggering the loss of ΔΨm, caspase-3, caspase-8, and caspase-9 activation, downregulation of BCL-XL expression as well as upregulation of NOXA, BAK, and P21. On the other hand, alliin endorsed clonogenicity, induced senescence, and did not demonstrate pro-apoptotic effects in breast cancer cells [129]. Allicin also suppressed proliferation and induced glioma cell apoptosis in vitro by intrinsic mitochondrial and extrinsic Fas/FasL mediated pathways [130].…”

Section: Organosulfur Compoundsmentioning

confidence: 97%

Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Fatima¹,

Baqri²,

Alsulimani

et al. 2021

Antioxidants

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Oxygen is indispensable for most organisms on the earth because of its role in respiration. However, it is also associated with several unwanted effects which may sometimes prove fatal in the long run. Such effects are more evident in cells exposed to strong oxidants containing reactive oxygen species (ROS). The adverse outcomes of oxidative metabolism are referred to as oxidative stress, which is a staple theme in contemporary medical research. Oxidative stress leads to plasma membrane disruption through lipid peroxidation and has several other deleterious effects. A large body of literature suggests the involvement of ROS in cancer, ageing, and several other health hazards of the modern world. Plant-based cures for these conditions are desperately sought after as supposedly safer alternatives to mainstream medicines. Phytochemicals, which constitute a diverse group of plant-based substances with varying roles in oxidative reactions of the body, are implicated in the treatment of cancer, aging, and all other ROS-induced anomalies. This review presents a summary of important phytochemicals extracted from medicinal plants which are a part of Indian ethnomedicine and Ayurveda and describes their possible therapeutic significance.

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“…An investigation indicated that allicin (45) induces apoptosis in breast cancer cells (MCF-7 and HCC-70) mediated by CASP3, CASP8 and CASP9 activation and loss of mitochondrial membrane potential (∆Ψm). These pro-apoptotic pathways (intrinsic and extrinsic) are also accompanied by upregulation of CDKN1A/p21 , PMAIP1/NOXA and BAK1 expression, as well as downregulation of BCL2L1 [ 339 ].…”

Section: Natural Compounds and Cancermentioning

confidence: 99%

New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways

Martelli

Omrani

Zarghooni

et al. 2022

Cancers

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Macroautophagy (autophagy) has been a highly conserved process throughout evolution and allows cells to degrade aggregated/misfolded proteins, dysfunctional or superfluous organelles and damaged macromolecules, in order to recycle them for biosynthetic and/or energetic purposes to preserve cellular homeostasis and health. Changes in autophagy are indeed correlated with several pathological disorders such as neurodegenerative and cardiovascular diseases, infections, cancer and inflammatory diseases. Conversely, autophagy controls both apoptosis and the unfolded protein response (UPR) in the cells. Therefore, any changes in the autophagy pathway will affect both the UPR and apoptosis. Recent evidence has shown that several natural products can modulate (induce or inhibit) the autophagy pathway. Natural products may target different regulatory components of the autophagy pathway, including specific kinases or phosphatases. In this review, we evaluated ~100 natural compounds and plant species and their impact on different types of cancers via the autophagy pathway. We also discuss the impact of these compounds on the UPR and apoptosis via the autophagy pathway. A multitude of preclinical findings have shown the function of botanicals in regulating cell autophagy and its potential impact on cancer therapy; however, the number of related clinical trials to date remains low. In this regard, further pre-clinical and clinical studies are warranted to better clarify the utility of natural compounds and their modulatory effects on autophagy, as fine-tuning of autophagy could be translated into therapeutic applications for several cancers.

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Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement

Cited by 27 publications

References 40 publications

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways

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