2013
DOI: 10.1001/jama.2013.6600
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Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer

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Cited by 9 publications
(9 citation statements)
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“…It has been suggested that PIK3CA mutation location and interaction of PIK3CA and KRAS mutations could affect outcomes [24]. In addition, the role of aspirin use before or after the diagnosis of CRC might affect the genetics of the disease [25]. As next generation sequencing becomes more widespread and larger patient cohorts are assembled, future work can better define the role of aspirin in personalized CRC care.…”
Section: Discussionmentioning
confidence: 99%
“…It has been suggested that PIK3CA mutation location and interaction of PIK3CA and KRAS mutations could affect outcomes [24]. In addition, the role of aspirin use before or after the diagnosis of CRC might affect the genetics of the disease [25]. As next generation sequencing becomes more widespread and larger patient cohorts are assembled, future work can better define the role of aspirin in personalized CRC care.…”
Section: Discussionmentioning
confidence: 99%
“…We note that research on colorectal cancer suggests that anti-cancer effects of aspirin depend on genetic factors (for example BRAF mutations), 5,6 and some individuals may be intrinsically resistant to the anti-cancer effects of aspirin. Accordingly, aspirin users who develop cancer may be a selected population with intrinsic resistance.…”
Section: Discussionmentioning
confidence: 92%
“…They exert pleiotropic effects, including the prevention of cardiovascular disease 2,3 and cancer, 4 although the latter may be confined to subpopulations. 5,6 Aspirin, NSAIDs, and COX-2 inhibitors target the cyclooxygenase enzymes, COX-1 and COX-2. 7,8 These enzymes promote angiogenesis and prevent apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…lung cancer is associated with asbestosis and smoking, colon cancer with inflammatory bowel disease (IBD), and lymphoma with celiac disease [8,17]. Furthermore, numerous experimental and epidemiologic studies, along with randomized clinical trials showed that long-term daily use of the nonsteroidal anti-inflammatory drug aspirin reduced the incidence of several cancers, especially those of the gastrointestinal tract [18-21]. The mechanism of action of the chemopreventive and anticancer effects of aspirin is not fully understood, but it has been attributed to its anti-inflammatory effects, specifically inhibition of prostaglandin-endoperoxide synthase 2 (formerly named cyclooxygenase 2), which is the rate-limiting step for the conversion of arachidonic acid to prostaglandins.…”
Section: Dual Relationship Between Inflammation and Cancermentioning
confidence: 99%