Differential effects of cannabinoid exposure and stress on plasma prolactin, growth hormone and corticosterone levels in male mice

Dalterio, S.; Michael, S.D.; Macmillan, B. T.; Bartke, Andrzej

doi:10.1016/0024-3205(81)90158-2

Cited by 30 publications

(6 citation statements)

References 22 publications

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“…In the doses employed in humans no sig nificant effect on plasma PRL was found [15], Little attention has been paid to the effects of THC on growth hormone (GH). However, systemic administration of THC was reported to lower plasma GH levels in rats [11] and mice [7]. Received: August 28, 1987 Accepted after revision: Novembers, 1987 The present work combined in vivo and in vitro ap proaches to determine the site at which THC acts to alter PRL and GH release in the rat.…”

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confidence: 99%

Hypothalamic Action of Delta-9-Tetrahydrocannabinol to Inhibit the Release of Prolactin and Growth Hormone in the Rat

et al. 1988

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The site of action of delta-9-tetrahydrocannabinol (THC) to inhibit the release of prolactin (PRL) and growth hormone (GH) was examined by in vivo and in vitro experiments. In conscious freely moving animals bearing implanted third ventricular (3 V) and external jugular cannulae, THC or the diluent was microinjected into the 3 V and blood samples were removed to determine the effect on plasma PRL and GH. Both the 0.4- and 4-µg dose injected intraventricularly resulted in a suppression of PRL and GH release as indicated by declines in plasma levels within 40–80 min which were highly significant statistically but not dose-related. The higher dose evoked a pulse of GH and/or PRL in most animals which preceded the lowering of hormonal levels. In the in vitro experiments dipersed anterior pituitary cells were incubated with 5 × 10^–8 or 5 × 10^–9M THC or the diluent for 5 days. Fresh culture medium was added to the cells after 3 days and the cells cultured for an additional 2 days. After this period, the cells were incubated for an additional 2 h in culture medium with or without THC plus a near maximal dose of thyrotropin-releasing hormone and GH-releasing factor (50 and 10 ng/ml, respectively) or the diluent to evaluate the response of PRL and GH release, respectively. Neither dose of THC altered the release or storage of the two hormones during culture or affected the response to the releasing hormones which is suggestive that there is no direct effect of THC on either GH or PRL release. The results of the combined in vivo and in vitro studies indicate that the action of THC to suppress PRL and GH release is mediated within the CNS probably by suppression of aminergic activity and peptide release.

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confidence: 99%

Hypothalamic Action of Delta-9-Tetrahydrocannabinol to Inhibit the Release of Prolactin and Growth Hormone in the Rat

et al. 1988

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“…The fact that rimonabant, being an antagonist for CB1, exerts the same inhibitory effect on GH secretion as THC (6–8), which is a CB1 agonist, would appear to be incongruent. However, the biphasic effect of different cannabinoids should be taken into account, which has been well known for several decades, and this effect gives rise to several physiological and behavioural parameters (31, 34), including endocrine secretion (35, 36) and even GH secretion (9).…”

Section: Discussionmentioning

confidence: 99%

“…GH secretion by the pituitary gland is regulated by two hypothalamic peptides with opposite actions, growth hormone‐releasing hormone (GHRH) and somatostatin (5). Δ 9 ‐THC and synthetic cannabinoids have been shown to inhibit GH secretion in rodents when acutely administered (6–8). On the other hand, it is still under debate whether cannabinoids are able to modulate GH secretion acting at the hypothalamic level or whether they also directly influence GH pituitary output.…”

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confidence: 99%

Peripheral Endocannabinoid System‐Mediated Actions of Rimonabant on Growth Hormone Secretion are Ghrelin‐Dependent

Al‐Massadi

Gabellieri

Trujillo

et al. 2010

J Neuroendocrinology

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The somatotroph axis is a crucial pathway regulating metabolism. Despite the fact that the endocannabinoid system has been also revealed as a potent modulator of energy homeostasis, little information is available concerning a putative interaction between these two systems. The aim of the present study was to determine the in vivo effects of the blockade of the cannabinoid receptor type 1 (CB1) over growth hormone (GH) secretion using the CB1 antagonist rimonabant. The results obtained show that the blockade of the CB1 peripheral receptor by i.p. injection of rimonabant significantly inhibited pulsatile GH secretion. Similarly, it was found that this injection significantly decreased ghrelin-induced GH secretion without any effect on growth hormone-releasing hormone (GHRH)-induced GH discharge. In situ hybridisation showed that the peripheral blockade of CB1 did not affect hypothalamic somatostatin mRNA levels; however, GHRH mRNA expression was significantly decreased. The blockade of the vagus nerve signal by surgical vagotomy eliminated the inhibitory action of rimonabant on GHRH mRNA and consequently on GH. On the other hand, the central CB1 blockade by i.c.v. rimonabant treatment was unable to reproduce the effect of peripheral blockade on GHRH mRNA, nor the GH response to ghrelin. In conclusion, the data reported in the present study establish, from a physiological point of view, the existence of a novel mechanism of GH regulation implicating the action of the cannabinoid receptor on the somatotroph axis.

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“…28 The decrease in the growth hormone seems to be of differential nature on administration of different cannabinoids. 29 Similarly a synthetic cannabinoid, HU-120, when administered in rats leads to dose dependent inhibition of the growth hormone. 30…”

Section: Animal Studiesmentioning

confidence: 99%

Cannabis and Endocrine system: A narrative review

Sharma

Balhara

2018

J Psychiatr Assoc Nepal

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Cannabis is one of the most abused substances worldwide. The active component of cannabis is THC which has multiple effects in the endocrine system in both animal models and humans. The interest of scientific community in endocrine effects of cannabis is recent. We present a narrative review of endocrine effects of cannabis in different organ system along with description of possible mechanism both in the animal models and as well as in humans. We also highlight the need of research in this area especially in the population of South East Asia.

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Differential effects of cannabinoid exposure and stress on plasma prolactin, growth hormone and corticosterone levels in male mice

Cited by 30 publications

References 22 publications

Hypothalamic Action of Delta-9-Tetrahydrocannabinol to Inhibit the Release of Prolactin and Growth Hormone in the Rat

Hypothalamic Action of Delta-9-Tetrahydrocannabinol to Inhibit the Release of Prolactin and Growth Hormone in the Rat

Peripheral Endocannabinoid System‐Mediated Actions of Rimonabant on Growth Hormone Secretion are Ghrelin‐Dependent

Cannabis and Endocrine system: A narrative review

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