Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test

Day, Mark L.; Pan, Jia Bao; Buckley, Michael; Cronin, Elizabeth A.; Hollingsworth, Peter R.; Hirst, Warren D.; Navarra, Rachel; Sullivan, James P.; Decker, Michael; Fox, Gerard B.

doi:10.1016/j.bcp.2006.12.004

Cited by 75 publications

(60 citation statements)

References 58 publications

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“…The results concur with previous findings following systemic administration of M100907 or SB242084 (Winstanley et al, 2003(Winstanley et al, , 2004 and suggest the NAc is an important site of action of these compounds. These data thus add to a growing body of evidence for an involvement of multiple neurotransmitter systems in the mediation and control of impulsive behavior, including in addition to 5-HT and DA, the noradrenergic Blondeau and Dellu-Hagedorn, 2007) and histaminergic (Day et al, 2007) systems. The present results indicate that selective 5-HT 2A receptor antagonists and/or 5-HT 2C receptor agonists may have beneficial effects in psychiatric disorders where co-existing impulsivity is often present, including ADHD, schizophrenia, and substance abuse.…”

Section: Serotonin-dopamine Interactionsmentioning

confidence: 57%

Opposing Roles for 5-HT2A and 5-HT2C Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task

Robinson

Dalley

Theobald

et al. 2007

Neuropsychopharmacol

130

110

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Serotonin (5-HT) is thought to play an important role in the regulation of behavioral inhibition. Studies manipulating 5-HT function in the rodent brain indicate that 5-HT receptors regulate distinct forms of impulsive behavior, including impulsive responding in the 5-choice serial reaction time task (5CSRTT). The present study investigates the loci of effects mediated by 5-HT 2A and 5-HT 2C receptors in attention and inhibitory response control using microinfusions targeted at the nucleus accumbens (NAc), prelimbic cortex (PL) and infralimbic cortex (IL). Rats were implanted with bilateral guide cannulas and received infusions of the selective 5-HT 2A receptor antagonist M100907 (0.1 and 0.3 mg) or selective 5-HT 2C receptor antagonist SB242084 (0.1 and 0.5 mg) immediately prior to testing. The results show that intra-NAc infusions of M100907 significantly decrease impulsive responding on the 5CSRTT and at the highest dose increased omissions as well. By contrast, infusions of SB242084 into the NAc selectively and dose-dependently increased impulsivity. Neither M100907 nor SB242084 significantly altered impulsive responding following either intra-PL or intra-IL administration. However, SB242084 significantly decreased omissions following intra-PL administration (0.5 mg only). These data reveal opposing effects on impulsivity following 5-HT 2A and 5-HT 2C blockade in the NAc. Our results suggest that the NAc, but not the PL or IL, is implicated in the mediation of the effects of M100907 and SB242084 on inhibitory response control during baseline 5CSRTT performance.

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Section: Serotonin-dopamine Interactionsmentioning

confidence: 57%

Opposing Roles for 5-HT2A and 5-HT2C Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task

Robinson

Dalley

Theobald

et al. 2007

Neuropsychopharmacol

130

110

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“…At the same time, increased activity in pyramidal neurons restores the conditions for STDP to occur. The presence of nicotine and increased threshold for STDP could reduce cognitive performance in healthy naive rodents [100]. Alternatively, since PFC neuronal activity could be increased during PFC-based cognitive behavior, nicotine may provide conditions under which signal-to-noise ratio in PFC information processing is enhanced, thereby improving cognitive performance [41,100].…”

Section: Nicotinic Achr Activation and Synaptic Plasticitymentioning

confidence: 99%

“…The presence of nicotine and increased threshold for STDP could reduce cognitive performance in healthy naive rodents [100]. Alternatively, since PFC neuronal activity could be increased during PFC-based cognitive behavior, nicotine may provide conditions under which signal-to-noise ratio in PFC information processing is enhanced, thereby improving cognitive performance [41,100]. It is possible that enhancing signal-tonoise for phasic activity within the PFC, rather than simply increasing excitability, could be an effective mechanism for cognition-enhancing drugs.…”

Section: Nicotinic Achr Activation and Synaptic Plasticitymentioning

confidence: 99%

Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences

Poorthuis

Goriounova

Couey

et al. 2009

Biochemical Pharmacology

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“…To this end, different behavioral paradigms were used to assess visuospatial attention as well as distinct forms of impulsivity, namely the 5-choice serial reaction time task (5-CSRTT) and the delayed reward paradigm that measure aspects of impulsive action and impulsive choice, respectively (for recent review, see Winstanley et al, 2006a). Whereas acute and (sub)chronic nicotine challenges have been shown to increase impulsivity and might result in improved visuospatial attention in the 5-CSRTT (Day et al, 2007;Grottick and Higgins, 2000;Hahn et al, 2002;Van Gaalen et al, 2006a), the present study focused on the long-term effects of adolescent nicotine exposure on 5-CSRTT performance in adulthood. Moreover, to explore putative long-lasting neuroplasticity in frontostriatal brain regions resulting from adolescent nicotine exposure, we also measured the electrically evoked release of (radiolabeled) dopamine in slices of the medial prefrontal cortex (mPFC) and nucleus accumbens (Acb) in separate groups of rats.…”

Section: Introductionmentioning

confidence: 99%

Long-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats

Counotte

Spijker

Burgwal

et al. 2008

Neuropsychopharmacol

151

134

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Adolescence is a developmental period, during which the brain and particularly medial prefrontal cortical (mPFC) regions thereof have not fully matured. Because epidemiological data have suggested that adolescent nicotine use may result in disturbances in cognitive function in adulthood, we investigated the long-term effects of adolescent nicotine exposure in rats. Male Wistar rats were exposed to either nicotine (three times daily, 0.4 mg/kg s.c.) or saline for 10 days during (postnatal day (PND) 34-43) or following (PND 60-69) adolescence. After 5 weeks during adulthood, separate groups of animals were tested in operant paradigms taxing attention and distinct measures of impulsivity. Visuospatial attention and impulsive action were tested in the five-choice serial reaction time task, whereas impulsive choice was assessed in the delayed reward task. Our data show that adolescent, but not postadolescent, nicotine exposure affects cognitive performance in adulthood and results in diminished attentional performance and increments in impulsive action, while leaving impulsive choice intact. This altered cognitive performance appeared to be associated with enhanced releasability of dopamine in the mPFC. Together, these data suggest that adolescence is a time window during which the brain is vulnerable to long-lasting cognitive disturbances resulting from nicotine exposure.

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Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test

Cited by 75 publications

References 58 publications

Opposing Roles for 5-HT2A and 5-HT2C Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task

Opposing Roles for 5-HT2A and 5-HT2C Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task

Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences

Long-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats

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