Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats

Yono, Makoto; Mane, Shrikant; Ai, Lin; Weiß, Robert M.; Latifpour, Jamshid

doi:10.1016/j.lfs.2008.06.006

Cited by 15 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ikeda et al. (2000) and Yono et al. (2008) showed that streptozotocin (STZ)‐induced diabetes in rats causes a significant reduction in prostatic weight and in serum testosterone levels and that the prostatic involution is accompanied by up‐regulation of transforming growth factor (TGF)‐β, a potent inhibitor of prostatic cell growth.…”

Section: Discussionmentioning

confidence: 99%

Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

Fávaro

Cagnon

2010

Int J Experimental Path

View full text Add to dashboard Cite

Diabetes causes harmful effects on prostatic morphology and function. However, there still are doubts about the occurrence of various diseases in the prostate, as well as abnormal angiogenesis in relation to diabetes. Thus, the aim of this study was to correlate and quantify the level of the steroid hormone receptors and the angiogenic and antiangiogenic factors in non-obese diabetic mice (Nod) after combined hormonal and insulin therapy. Sixty mice were divided into six groups after 20 days of diabetes: the control group received 0.9% NaCl, as did the diabetic group. The diabetic-insulin group received insulin, the diabetic-testosterone group received testosterone cypionate, the diabetic-oestrogen group received 17β-oestradiol, and the diabetic-insulin-testosterone-oestrogen group received insulin, testosterone and oestrogen simultaneously. After 20 days, the ventral lobe was processed for immunocytochemical and hormonal analyses. The results showed that the lowest serum testosterone and androgen receptor levels were found in the diabetic group and the highest testosterone and androgen receptor levels in the diabetic-insulin-testosterone-oestrogen group. The serum oestrogen level and its receptor showed changes opposite to those of testosterone and its receptor. The endostatin reactivity was mainly decreased in diabetic mice. The greatest IGFR-1 and VEGF reactivities occurred in diabetic mice. Thus, diabetes led to the prostatic hormonal imbalance, affecting molecular dynamics and angiogenesis in this organ. Combined insulin and steroid hormone therapy partially restored the hormonal and angiogenic imbalance caused by diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

Fávaro

Cagnon

2010

Int J Experimental Path

View full text Add to dashboard Cite

show abstract

“…In addition, mouse models of hypoinsulinemia cause significant prostate growth arrest (Ikeda et al, 2000; Vikram et al, 2008). Confirming a role for hyperinsulinemia in prostatic growth effects rather than diabetes in general, models of type 1 diabetes demonstrate no effect on prostatic growth (Yono et al, 2005; Yono et al, 2008). …”

Section: Role Of Igf Signaling In the Association Of Prostatic Enlmentioning

confidence: 94%

Role of interleukins, IGF and stem cells in BPH

2011

View full text Add to dashboard Cite

The condition known as benign prostatic hyperplasia may be defined as a benign enlargement of the prostate gland resulting from a proliferation of both benign epithelial and stromal elements. It might also be defined clinically as a constellation of lower urinary tract symptoms (LUTSs) in aging men. The purpose of this review is to consider the ways in which inflammatory cytokines belonging to the interleukin family, members of the IFG family, and stem cells may contribute to the development and progression of BPH-LUTS. This might occur in three mechanisms: One, interleukin signaling, IFG signaling and stem cells may contribute to reactivation of developmental growth mechanisms in the adult prostate leading to tissue growth. Two, given that epidemiologic studies indicate an increased incidence of BPH-LUTS in association with obesity and diabetes, IFG signaling may provide the mechanistic basis for the effect of diabetes and obesity on prostate growth. Three, expression of interleukins in association with inflammation in the prostate may induce sensitization of afferent fibers innervating the prostate and result in increased sensitivity to pain and noxious sensations in the prostate and bladder and heightened sensitivity to bladder filling.

show abstract

“…Polyunsaturated FAs are ligands for the PPAR , which is involved in the regulation of cell differentiation and proliferation (Morales-Garcia et al, 2011;Parast et al, 2009), and therefore appears to represent a possible link between diet and prostatic growth (Escobar et al, 2009). Prostatic atrophy and increased apoptosis in the hypoinsulinemic rats (induced by selective -cell toxins, either streptozotocin or alloxan) further supports the view that insulin plays a central role in the prostatic growth and development (Arcolino et al, 2010;Ikeda et al, 2000;Suthagar et al, 2009;Vikram et al, 2008;Yono et al, 2008;Yono et al, 2005). Increased cell proliferation and enlargement of ventral prostate in rats kept on the diet rich in saturated fat was observed (Vikram et al, 2010b;Vikram et al, 2010c).…”

Section: Evidence From In-vivo Experimentsmentioning

confidence: 75%

Lipids in the Pathogenesis of Benign Prostatic Hyperplasia: Emerging Connections

Vikram¹,

Ramarao²

2012

Dyslipidemia - From Prevention to Treatment

View full text Add to dashboard Cite

Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats

Cited by 15 publications

References 18 publications

Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

Role of interleukins, IGF and stem cells in BPH

Lipids in the Pathogenesis of Benign Prostatic Hyperplasia: Emerging Connections

Contact Info

Product

Resources

About