Differential effects of dietary fat on chick plasma and liver composition and HMG-CoA reductase activity

Castillo, M.; Hortal, José H; Gil-Villarino, Almudena; Luque, P.; Iglesias, J.; Garcia-Peregrin, E.

doi:10.1016/s0955-2863(98)00086-2

Cited by 21 publications

(11 citation statements)

References 51 publications

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“…However, it is important to note that this hypercholesterolemia was observed in rabbit after 26-32 days of starvation (25), whereas our results show a more rapid response to food-deprivation in chick (only 12 h), corroborating the suitability of using this animal as an experimental model in studies on cholesterol metabolism. Our previous studies showed that cholesterol content of chick liver increased with starvation: 2.78±0.04 mg/g tissue under postprandial conditions (29) versus 3.75 ± 0.21 mg/g tissue under food-deprivation con- (6). These results support the hypothesis that cholesterol stored in the lipid droplet of the adipose tissue cell is released into plasma and is the chief source of the hypercholesterolemia observed during starvation (25).…”

Section: Discussionsupporting

confidence: 77%

“…The chick has been recognized as a suitable model for studies on the cholesterol metabolism and transport because it is highly sensitive to dietary modifications (4,6,16). The elevation in chick plasma lipid caused by saturated fat or cholesterol feeding is largely the result of increased low density (LDL) and very low density lipoproteins (VLDL) pools, irrespective of the major circulating lipoprotein class (21).…”

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confidence: 99%

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Influencia del ayuno en el efecto del aceite de coco sobre la composición del plasma y de las lipoproteínas de pollo

Garcı́a-Fuentes

Gil-Villarino

Zafra

et al. 2003

J. Physiol. Biochem.

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For a better understanding of the hyperlipidemic function of saturated fat, we have studied the effects of diet supplementation with 10-20% coconut oil on the chick plasma and lipoprotein composition under postprandial and starvation conditions. A significant hypercholesterolemia was found in chicks fed the standard diet after 12 h of food deprivation. In these conditions, LDL-cholesterol also increased, whereas triglyceride levels were reduced in HDL, VLDL and chylomicron fractions. Coconut oil induced a significant hypercholesterolemia under both conditions, also increasing the plasma triglyceride content under postprandial conditions, but not after starvation. Coconut oil feeding increased all the chemical components of HDL, especially under postprandial conditions, but did not affect the HDL-triglycerides under food-deprivation conditions. Total cholesterol and triglyceride levels in LDL increased after coconut oil supplementation to the diet. Differences were more pronounced under postprandial conditions. Changes in VLDL and chylomicron composition were less evident.

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Section: Discussionsupporting

confidence: 77%

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confidence: 99%

Influencia del ayuno en el efecto del aceite de coco sobre la composición del plasma y de las lipoproteínas de pollo

Garcı́a-Fuentes

Gil-Villarino

Zafra

et al. 2003

J. Physiol. Biochem.

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“…This enzyme activity is significant to the EPA + DHA content in the feed, and these obtained results were similar to those reported earlier by Le Jossic et al (2005) in rodents fed on tuna fish oil. Similarly, Castillo et al (1999) observed lower activity of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthetic pathway, when chickens were fed with menhaden fish oil. FFO in our study can be a sustainable alternative to commercial FO in broiler feed as it seems to have a similar effect in reducing cholesterol and triglyceride concentrations.…”

Section: Broiler Meat Lipid Profilementioning

confidence: 87%

Effects of fermentatively recovered fish waste lipids on the growth and composition of broiler meat

Muhammed

Domendra

Muthukumar

et al. 2015

British Poultry Science

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1. The aim of the present study was to evaluate the effects of feeding fermentatively recovered fish oil (FFO) from fish processing waste (FPW), on the performance and carcass composition of broilers. A total of 60 one-d-old VenCobb broiler chicks randomly assigned to 5 treatment groups were studied. 2. The birds were randomly assigned to treatment groups and fed with a normal commercial diet (control, T1), a diet with 2% groundnut oil (positive control, T2), a diet with 1% FFO (T3), a diet with 1.5% FFO (T4) and a diet with 2% FFO (T5). Performance and growth parameters (feed intake and body weight) and fatty acid composition of serum, liver and meat were determined. 3. The performance characteristics of broiler meat did not differ among treatments. Feeding FFO reduced total cholesterol concentration in serum, meat and liver of the FFO-fed groups (T3 to T5) as compared to both the controls (T1 and T2), but there was no significant difference in triglyceride concentration between treatments. Increased concentrations of EPA and DHA in serum, liver and meat of FFO-fed groups, as compared to both controls, were observed as the FFO concentration increased. 4. The study clearly demonstrates the value of oil recovered from FPW in addition to addressing the environmental issues related to disposal of such biological waste.

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“…It has been reported that medium chain fatty acids of coconut oil raise triglyceride levels in humans, especially lauric acid, the principal fatty acid of coconut oil 22) . Studies conducted in chicks have shown that feeding coconut oil alone does not cause hypertriglyceridemia, but on supplementation with 1% cholesterol, severe hypertriglyceridemia resulted 23) . In rabbits, elevated triglyceride concentration on feeding coconut oil 0.5% cholesterol compared to olive oil 0.5% cholesterol was found to be due to increased hepatic secretion of VLDL and decreased hepatic clearance of VLDL triglyceride 24) .…”

Section: Discussionmentioning

confidence: 99%

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Sabitha

Vasudevan

Kamath

2010

JAT

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Aim: Dietary fats may affect coronary artery disease risk by influencing factors other than serum cholesterol. The effect of diets containing coconut oil and sunflower oil without cholesterol supplementation on oxidative stress and lipid peroxidation was studied in male New Zealand White rabbits. Methods: Animals assigned to four groups (control, cholesterol-fed, coconut oil-fed and sunflower oil-fed), given an isocaloric diet and studied for 6 months. The lipid profile, reduced glutathione, glutathione peroxidase, superoxide dismutase, vitamin C and lipid peroxidation were evaluated at the beginning of the study, at the third month and at the end of the study period. Results: Serum lipid values did not show significant variation between animals fed coconut oil and sunflower oil, but total cholesterol, triglycerides and LDL-cholesterol were significantly higher and HDL-cholesterol was reduced in cholesterol-fed animals. Lipid peroxidation was higher in cholesterol-fed and sunflower oil-fed rabbits compared to controls and coconut oil-fed rabbits. Though other parameters such as reduced glutathione, glutathione peroxidase, superoxide dismutase and ascorbate did not vary between the two oil-fed rabbit groups, cholesterol-fed rabbits showed severe oxidative stress. Conclusion: We conclude that in the absence of cholesterol supplementation, coconut oil intake up to 30% of daily energy supply did not cause hypercholesterolemia or oxidative stress in rabbits.J Atheroscler Thromb, 2010; 17:213-218.

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Differential effects of dietary fat on chick plasma and liver composition and HMG-CoA reductase activity

Cited by 21 publications

References 51 publications

Influencia del ayuno en el efecto del aceite de coco sobre la composición del plasma y de las lipoproteínas de pollo

Influencia del ayuno en el efecto del aceite de coco sobre la composición del plasma y de las lipoproteínas de pollo

Effects of fermentatively recovered fish waste lipids on the growth and composition of broiler meat

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

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