Differential effects of escitalopram challenge on disgust processing in obsessive–compulsive disorder

Löchner, Christine; Simmons, Candice; Kidd, Martin; Chamberlain, Samuel R.; Fineberg, Naomi; Honk, Jack van; Ipser, Jonathan; Stein, Dan J.

doi:10.1016/j.bbr.2011.09.029

Cited by 20 publications

(15 citation statements)

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“…Despite evidence for a disgust recognition deficit on a metaanalytic level, a great number of individual studies did not observe any deficits in facial emotion recognition [e.g., (36,37,42,43,46,47)], which may suggest that deficits are associated with specific subgroups of patients or task characteristics. Although some studies show a positive relation between symptom severity and disgust recognition impairment (40,45,48), many studies did not and the meta-analysis by Daros et al (41) was not able to detect such a relation based on the studies included in their review. Some studies additionally show that disgust recognition impairments are present in some but not all patients (40,48).…”

Section: Section Summary and Discussion: Social Cue Perceptionmentioning

confidence: 96%

“…Some studies additionally show that disgust recognition impairments are present in some but not all patients (40,48). Interestingly, recognition of facial expressions of disgust also seem to be enhanced or restored by cognitive behavioral therapy and SSRI treatment (45,49), suggesting that treatment status may play a role. Clearly, more research into possible moderating variables is required.…”

Section: Section Summary and Discussion: Social Cue Perceptionmentioning

confidence: 99%

“…Two studies specifically investigated the effect of treatment on facial emotion recognition, which suggest that medication or therapy may improve or remediate disgust recognition. Lochner et al (45) administered a single dose of the selective serotonin reuptake inhibitor (SSRI) escitalopram to OCD patients, which is an antidepressant considered as a first-line option in the treatment of OCD (59). Compared to controls, patients showed no significant deficits in the recognition of disgust in the placebo condition, although patients were significantly more accurate after a single administration of escitalopram, especially when they were already receiving SSRI treatment.…”

Section: Facial Emotion Recognition In Patients With Ocdmentioning

confidence: 99%

“…In an attempt to clarify inconsistencies between studies, Daros, Zakzanis, and Rector (41) conducted a meta-analytic review on facial emotion recognition including ten studies in adolescent (60) and adult OCD patients (36,37,40,42,45,(48)(49)(50)61) (not discussed in the current review as the article was not available in . OCD patients were also impaired in the recognition of negative emotions as a whole (Cohen's d = −0.34) and had particularly difficulties with the recognition of disgust (Cohen's d = −0.59) and anger (Cohen's d = −0.36).…”

Section: Facial Emotion Recognition In Patients With Ocdmentioning

confidence: 99%

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Social Cognition and Obsessive-Compulsive Disorder: A Review of Subdomains of Social Functioning

2020

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Disturbances in social cognitive processes such as the ability to infer others' mental states importantly contribute to social and functional impairments in psychiatric disorders. Yet, despite established social, emotional, and cognitive problems, the role of social cognition in obsessive-compulsive disorder is largely overlooked. The current review provides a first comprehensive overview of social (neuro)cognitive disturbances in adult patients with obsessive-compulsive disorder. Results of our review indicate various social cognitive alterations. Patients with obsessive-compulsive disorder show deficits in the recognition of affective social cues, specifically facial expressions of disgust, and more general deficits in theory of mind/mentalizing. Additionally, patients show heightened affective reactions and altered neural responding to emotions of self and others, as well as poor emotion regulation skills, which may contribute to poor social functioning of patients. However, the discrepancies in findings and scarcity of studies make it difficult to draw firm conclusions with regard to the specificity of social cognitive disturbances. The review offers directions for future research and highlights the need to investigate obsessive-compulsive disorder from an interactive social neurocognitive perspective in addition to the prevalent passive spectator perspective to advance our understanding of this intricate and burdensome disorder.

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Section: Section Summary and Discussion: Social Cue Perceptionmentioning

confidence: 96%

Section: Section Summary and Discussion: Social Cue Perceptionmentioning

confidence: 99%

Section: Facial Emotion Recognition In Patients With Ocdmentioning

confidence: 99%

Section: Facial Emotion Recognition In Patients With Ocdmentioning

confidence: 99%

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Social Cognition and Obsessive-Compulsive Disorder: A Review of Subdomains of Social Functioning

2020

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“…On the other hand, a recent study on disgust recognition in obsessive compulsive disorder, a disorder with many similarities to BDD, found that chronic SSRI failed to normalise abnormal disgust recognition under a pharmacological challenge. The authors hypothesised that abnormal face processing in OCD represents a trait phenomenon (Lochner et al, 2012). In addition, one study in the depressed elderly has reported that chronic SSRI improved the recognition of negative as well as positive faces in BDD patients (Savaskan, Müller, Böhringer, Schulz, & Schächinger, 2008).…”

Section: Limitationsmentioning

confidence: 99%