Differential Effects of Fasting and Nicotinic Acid on Various Enzymatic Activities of the 9,000 <i>g</i> Fraction of the Perfused Rat Liver

Abstract

Perfused livers obtained from rats fasted for 24 or 48 h show a marked impairment of the N-demethylation (substrate aminopyrine) without major changes of the O-demethylation (p-nitro anisol) and hydroxylation (aniline). The infusion with nicotinic acid restored N-demethylation but it inhibited O-demethylation and hydroxylation.