Differential Effects of Flavonoid Compounds on Tumor Promoter-Induced Activation of the Human CYP1A2 Enhancer

Shih, Hsueh; Pickwell, George V.; Quattrochi, Linda C.

doi:10.1006/abbi.1999.1550

Cited by 90 publications

(48 citation statements)

References 29 publications

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“…Among the 50 tomato accessions, IT229711, IT265355, and IT236523 showed the highest contents of quercetin, naringenin, and kaempferol, respectively. Flavonoids, in particular those belonging to the class of flavonols (such as kaempferol and quercetin), are potentially health-protecting components in human diet due to their high antioxidant capacity and their ability of inducing human protective enzyme systems (Dugas et al 2000;Duthie and Crozier 2000;Ng et al 2000;Shih et al 2000). These findings suggest that flavonoids might offer protection against major diseases such as coronary heart diseases and cancer (Hertog and Hollman 1996;Steinmetz and Potter 1996;Trevisanato and Kim 2000).…”

Section: Discussionmentioning

confidence: 99%

Chemical Constitutions and Antioxidant Activities of Tomato Leaf Extracts

Lee¹,

Lee²,

Ma³

et al. 2016

Plant Breed. Biotech.

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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT The present study aimed to determine the contents of five flavonols and two glycoalkaloids as well as the antioxidant activities of leaf ethanol extracts of 50 tomato accessions. The antioxidant activity was assessed using different tests: 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2,2-diphenyl-1-picryl hydrazyl (DPPH), nitric oxide (NO), and total polyphenol content (TPC). Flavonols and glycoalkaloids contents were determined using a high performance liquid chromatography-diode array detector system. Among five flavonols and two glycoalkaloids, naringenin and tomatine were detected in tomato leaves at high concentrations. Of the 50 tomato accessions, IT 229711, IT2365203, and IT 207224 were found to have the highest contents of quercetin, kaempferol, and tomatine, respectively. Leaf extract of IT189949 exhibited the highest relative antioxidant capacity index (RACI). Among the five flavonols, myricetin showed positive correlations with DPPH, ABTS, and NO, while isorhamnetin had positive correlation with DPPH. These results will expand the chemical constitution database and provide information on tomato leaves. They are valuable for the development of functional foods or feed-additives.

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Section: Discussionmentioning

confidence: 99%

Chemical Constitutions and Antioxidant Activities of Tomato Leaf Extracts

Lee¹,

Lee²,

Ma³

et al. 2016

Plant Breed. Biotech.

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“…These chemopreventive effects of flavonoids are possibly exerted through a variety of mechanisms, including modification of detoxification enzymes 16,17) and free radical scavenging.…”

Section: Discussionmentioning

confidence: 99%

The Chemopreventive Effect of Taxifolin Is Exerted through ARE-Dependent Gene Regulation

Lee

Hyun

Dangaa³

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Regulation of the inducibility of most CYPs involves transcriptional regulation and post-transcriptional mRNA stabilization. [12][13][14] The profile of the mRNA abundance of CYPs therefore provides important information. We examine in the present study the effect of dietary soy isoflavone on the gene expression of major CYPs.…”

mentioning

confidence: 99%