Differential effects of formaldehyde exposure on the cell influx and vascular permeability in a rat model of allergic lung inflammation

Lino-dos-Santos-Franco, Adriana; Domingos, Helori Vanni; Oliveira, Ana Paula Ligeiro de; Breithaupt‐Faloppa, Ana Cristina; Peron, Jean Pierre Schatzmann; Bolonheis, Simone Marques; Muscará, Marcelo Nícolas; Oliveira‐Filho, Ricardo Martins; Vargäftig, B. Boris; Tavares-de-Lima, Wothan

doi:10.1016/j.toxlet.2010.05.022

Cited by 44 publications

(23 citation statements)

References 25 publications

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“…In this study, exposure to 10 % formalin resulted in significant decrease of SOD activity in rat's lung. This result is supported by finding from Lino-Dos-Santos-Franco et al (2010) [22] which concluded that formaldehyde cause a decrease in SOD activity when compared to the naï ve group. SOD is a ubiquitous enzyme with an essential function in protecting aerobic cells against oxidative stress by catalyzing superoxide (O 2ˉ) radicals to hydrogen peroxide (H 2 O 2 ) [23].…”

Section: Discussionsupporting

confidence: 66%

Effect of Centella Asiatica on Oxidative Stress in Rat Lung after Formalin Exposure

H¹,

Nur-Khairah-Izzati²,

Rasyidah³

et al. 2015

JOMB

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Pegaga or Centella asiatica commonly used in traditional medicine was believed to possess antioxidant effect that can control the generation of free radicals. This study aims to investigate the protective effect of Centella asiatica on antioxidant status in rat lung following formalin exposure. Twenty male Wistar rats were divided into four groups: (1): control; (2): exposed with 10 % formalin; (3): exposed with 10 % formalin and treated with ethanolic extract of C. asiatica; (4): treated with ethanolic extract of C. asiatica. Exposure of 10 % formalin was performed through inhalation and C. asiatica was given orally. After the treatment, the rat's lungs were harvested for determination of malondialdehye and activities of superoxide dismutase and catalase. Exposure to 10 % formalin did not increase the concentration of malondialdehye. However, higher malondialdehye level was noted in group which exposed with 10 % formalin and received ethanolic extract of C. asiatica. A significant decrease of superoxide dismutase activities was observed in rat's lung between all groups as compared to control group, yet no significant difference was observed in catalase activities. In conclusion, exposure 10 % formalin was unable to induced oxidative stress in rat lung but supplementation of C. asiatica are able to increase superoxide dismutase level in rat lung but not for catalase. 

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Section: Discussionsupporting

confidence: 66%

Effect of Centella Asiatica on Oxidative Stress in Rat Lung after Formalin Exposure

H¹,

Nur-Khairah-Izzati²,

Rasyidah³

et al. 2015

JOMB

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“…Bone marrow HSC, in which leukemia originates (Passegue et al, 2003), are sensitive to oxidative stress, exposure to which causes DNA damage, premature senescence, and loss of stem cell function (Yahata et al, 2011). FA was previously shown to induce oxidative stress in multiple tissues, including lymphocytes, in exposed rats and mice (Gulec et al, 2006; Lino-dos-Santos-Franco et al, 2011; Lino-Dos-Santos-Franco et al, 2010; Matsuoka et al, 2010; NTP, 2010b; Wang et al, 2012). In two recent new studies, we reported the significant dose-dependent induction of oxidative stress in multiple organs, including bone marrow, of mice exposed to FA (0.5–3.0 mg/m 3 ) by nose-only inhalation (Ye et al, 2013; Zhang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells

Ji¹,

Li²,

Fromowitz³

et al. 2014

Toxicology Letters

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Although formaldehyde (FA) has been classified as a human leukemogen, the mechanisms of leukemogenesis remain elusive. Previously, using colony-forming assays in semi-solid media, we showed that FA exposure in vivo and in vitro was toxic to human hematopoietic stem/progenitor cells. In the present study, we have applied new liquid in vitro erythroid expansion systems to further investigate the toxic effects of FA (0–150 µM) on cultured mouse and human hematopoietic stem/progenitor cells. We determined micronucleus (MN) levels in polychromatic erythrocytes (PCEs) differentiated from mouse bone marrow. We measured cell growth, cell cycle distribution, and chromosomal instability, in erythroid progenitor cells (EPCs) expanded from human peripheral blood mononuclear cells. FA significantly induced MN in mouse PCEs and suppressed human EPC expansion in a dose-dependent manner, compared with untreated controls. In the expanded human EPCs, FA slightly increased the proportion of cells in G2/M at 100 µM and aneuploidy frequency in chromosomes 7 and 8 at 50 µM. Our findings provide further evidence of the toxicity of FA to hematopoietic stem/progenitor cells and support the biological plausibility of FA-induced leukemogenesis.

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“…Previously in mice, inhalation of FA at low doses (0.1 ppm) was shown to influence the oxidative stress response in a tissue‐specific manner [Matsuoka et al, ]. In rats, oxidative stress previously has been implicated as a mechanism of FA toxicity in liver, plasma, lymphocytes, heart, and brain [NTP, ], ovaries [Wang et al, ], lung [Lino‐Dos‐Santos‐Franco et al, ], cardiac cells and tissue [Gulec et al, ], and testes [Zhou et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress is a potential mechanism by which FA induces systemic toxicity and has been shown to occur in multiple tissues in FA‐exposed rats and mice [Gulec et al, ; Lino‐Dos‐Santos‐Franco et al, ; Matsuoka et al, ; NTP, ; Wang et al, ]. Urinary 15‐F 2t isoprostane, a marker of oxidative stress, was increased in male laminate industry‐exposed workers compared with unexposed control office workers [Romanazzi et al, ].…”

Section: Introductionmentioning

confidence: 99%

Inhaled formaldehyde induces DNA–protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice

Wei

et al. 2013

Environ and Mol Mutagen

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Formaldehyde (FA), a major industrial chemical and ubiquitous environmental pollutant, has been classified as a leukemogen. The causal relationship remains unclear, however, due to limited evidence that FA induces toxicity in bone marrow, the site of leukemia induction, and in other distal organs. Although induction of DNA-protein crosslinks (DPC), a hallmark of FA toxicity, was not previously detected in the bone marrow of FA-exposed rats and monkeys in studies published in the 1980s, our recent studies showed increased DPC in the bone marrow, liver, kidney, and testes of exposed Kunming mice. To confirm these preliminary results, in the current study we exposed BALB/c mice to 0, 0.5, 1.0, and 3.0 mg m(-3) FA (8 hr per day, for 7 consecutive days) by nose-only inhalation and measured DPC levels in bone marrow and other organs of exposed mice. As oxidative stress is a potential mechanism of FA toxicity, we also measured glutathione (GSH), reactive oxygen species (ROS), and malondialdehyde (MDA), in the bone marrow, peripheral blood mononuclear cells, lung, liver, spleen, and testes of exposed mice. Significant dose-dependent increases in DPC, decreases in GSH, and increases in ROS and MDA were observed in all organs examined (except for DPC in lung). Bone marrow was among the organs with the strongest effects for DPC, GSH, and ROS. In conclusion, exposure of mice to FA by inhalation induced genotoxicity and oxidative stress in bone marrow and other organs. These findings strengthen the biological plausibility of FA-induced leukemogenesis and systemic toxicity.

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Differential effects of formaldehyde exposure on the cell influx and vascular permeability in a rat model of allergic lung inflammation

Cited by 44 publications

References 25 publications

Effect of Centella Asiatica on Oxidative Stress in Rat Lung after Formalin Exposure

Effect of Centella Asiatica on Oxidative Stress in Rat Lung after Formalin Exposure

Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells

Inhaled formaldehyde induces DNA–protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice

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