“…However, hypothalamic glial cells not only participate in pathological events, such as the inflammatory response that occurs as a consequence of HFD consumption (Milanski et al 2009, Thaler et al 2012, Buckman et al 2014, Valdearcos et al 2014, Yan et al 2014), but they are also intricately involve in the physiological control of the surrounding neurons, including those dictating energy balance. The importance of this relationship is even further emphasized by the fact that these glial cells express receptors and systems of transport for numerous metabolic hormones and factors (Boyles et al 1985, Vielkind et al 1990, Zhu et al 1990, Vannucci et al 1997, Marty et al 2005, Pan et al 2008, Hsuchou et al 2009, Baquedano et al 2013, suggesting that at least part of the central effects of these metabolic signals are mediated through these non-neuronal cells. Thus, a deeper understanding of glial cell function will allow both a better understanding of their role in normal brain physiology, as well as their participation in pathological processes, and hopefully lead to the identification of new therapeutic targets for obesity treatment.…”