2011
DOI: 10.1016/j.ejcb.2011.03.006
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Differential effects of growth factors on oligodendrocyte progenitor migration

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Cited by 17 publications
(17 citation statements)
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“…Our studies along with the others' have confirmed that OPC migration does not require continuous exposure to PDGF and it is regulated by the ERK-signaling pathway (Frost et al 1996(Frost et al , 2009Tsai et al 2002). Our earlier study (Vora et al 2011), showed that transient exposure to PDGF-A at low concentration (1 ng/ml) did not show any significant migration compared to the control cells. Even so the transient exposure at 10 ng/ml showed comparable OPC migration to that of continuously exposed cells (Vora et al 2011).…”
Section: Discussionsupporting
confidence: 92%
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“…Our studies along with the others' have confirmed that OPC migration does not require continuous exposure to PDGF and it is regulated by the ERK-signaling pathway (Frost et al 1996(Frost et al , 2009Tsai et al 2002). Our earlier study (Vora et al 2011), showed that transient exposure to PDGF-A at low concentration (1 ng/ml) did not show any significant migration compared to the control cells. Even so the transient exposure at 10 ng/ml showed comparable OPC migration to that of continuously exposed cells (Vora et al 2011).…”
Section: Discussionsupporting
confidence: 92%
“…Our earlier studies have shown that the effect of PDGF-A on OPC migration is dose-and time-dependent (Frost et al 2009;Vora et al 2011), however, the involvement of ECM in the regulation of PDGF-A mediated OPC migration was not clear. Therefore, we first investigated the individual effects of PDGF-A and FN on OPC migration in which PLL was used as control matrix.…”
Section: Short-term Exposure To Pdgf-a Requires Fn Engagement To Augmmentioning
confidence: 93%
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