Differential Effects of <i>Wedelia chinensis</i> on Human Glioblastoma Multiforme Cells

Chen, Li-Jeng; Hsu, Tsai‐Ching; Yeh, Pei-Jung; Yow, Jia Le; Chang, Chia‐Yi; Lin, Chao‐Nan; Tzang, Bor‐Show

doi:10.1177/15347354211000119

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…(Birzu et al, 2020). In addition, the current first‐line treatments for GBM can almost not effectively prolong survival, so there is an urgent need for new therapeutic approaches and new therapeutic agents for GBM (Chen et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

Hao

Zhang

et al. 2023

Chem Biol Drug Des

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Glioblastoma (GBM) is the most malignant brain tumor and incurable. Medicarpin (MED), a flavonoid compound from the legume family, has multiple targets and anticancer properties. However, the role of MED in GBM remains unclear. The objective of this study was to explore the effects of MED on the apoptosis of GBM and to explain the potential molecular mechanisms. We found that the IC50 values of U251 and U‐87 MG cells treated with MED for 24 h were 271 μg/mL and 175 μg/mL, and the IC50 values for 48 h were 154 μg/mL and 161 μg/mL, respectively. Additionally, the cell cycle of U251 and U‐87 MG cells were arrested at the G2/M phase. Furthermore, the apoptosis rate of U251 and U‐87 MG cells increased from 6.26% to 18.36% and 12.46% to 31.33% for 48 h, respectively. The migration rate of U251 and U‐87 MG decreased from 20% to 5% and 25% to 15% for 12 h and these of U251 and U‐87 MG decreased from 50% to 28% and 60% to 25% for 24 h. MED suppressed GBM tumorigenesis, and improved survival rate of tumor‐bearing mice. Taken together, MED triggered GBM apoptosis through upregulation of pro‐apoptotic proteins (BID, BAX, CASP3, CASP8, and CYCS), showed strong inhibitory effects on cell proliferation and cell migration, and displayed anti‐tumor activity in nude mice.

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Section: Discussionmentioning

confidence: 99%

Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

Hao

Zhang

et al. 2023

Chem Biol Drug Des

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“…Apigenin regulates the autophagy activities by increasing the LC3II/I ratio and expressions of Atg-7, Atg-5 and beclin-1 levels and decreasing p62 levels in U87-MG cells [ 87 ]. Apigenin also enhanced PARP cleavage at 40 and 80 μM, with the indication of loss of DNA repair and G2/M cell cycle arrest [ 24 ].…”

Section: Flavonoids and The Mechanism Of Action Against High-grade Ad...mentioning

confidence: 99%

Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

2023

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High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of the central nervous system. Despite the advancements in the multimodality treatment of high-grade adult-type diffuse gliomas, the five-year survival rates still remain poor. The biggest challenge in treating high-grade adult-type diffuse gliomas is the intra-tumor heterogeneity feature of the glioma tumors. Introducing dietary flavonoids to the current high-grade adult-type diffuse glioma treatment strategies is crucial to overcome this challenge, as flavonoids can target several molecular targets. This review discusses the anticancer mechanism of flavonoids (quercetin, rutin, chrysin, apigenin, naringenin, silibinin, EGCG, genistein, biochanin A and C3G) through targeting molecules associated with high-grade adult-type diffuse glioma cell proliferation, apoptosis, oxidative stress, cell cycle arrest, migration, invasion, autophagy and DNA repair. In addition, the common molecules targeted by the flavonoids such as Bax, Bcl-2, MMP-2, MMP-9, caspase-8, caspase-3, p53, p38, Erk, JNK, p38, beclin-1 and LC3B were also discussed. Moreover, the clinical relevance of flavonoid molecular targets in high-grade adult-type diffuse gliomas is discussed with comparison to small molecules inhibitors: ralimetinib, AMG232, marimastat, hydroxychloroquine and chloroquine. Despite the positive pre-clinical results, further investigations in clinical studies are warranted to substantiate the efficacy and safety of the use of flavonoids on high-grade adult-type diffuse glioma patients.

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“…Several compounds including flavonoids, diterpenes, triterpene saponins, and phytosteroids were reported in this extract. Recently extensive studies have demonstrated the anti-cancer properties of WCE against prostate, lung, breast, colon, glioblastoma, and pancreatic cancer cells [25].…”

Section: Data Collectionmentioning

confidence: 99%

Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells

Esmaeili

Lohrasebi

Mohammadi‐Dehcheshmeh

et al. 2021

Cells

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Predicting cancer cells’ response to a plant-derived agent is critical for the drug discovery process. Recently transcriptomes advancements have provided an opportunity to identify regulatory signatures to predict drug activity. Here in this study, a combination of meta-analysis and machine learning models have been used to determine regulatory signatures focusing on differentially expressed transcription factors (TFs) of herbal components on cancer cells. In order to increase the size of the dataset, six datasets were combined in a meta-analysis from studies that had evaluated the gene expression in cancer cell lines before and after herbal extract treatments. Then, categorical feature analysis based on the machine learning methods was applied to examine transcription factors in order to find the best signature/pattern capable of discriminating between control and treated groups. It was found that this integrative approach could recognize the combination of TFs as predictive biomarkers. It was observed that the random forest (RF) model produced the best combination rules, including AIP/TFE3/VGLL4/ID1 and AIP/ZNF7/DXO with the highest modulating capacity. As the RF algorithm combines the output of many trees to set up an ultimate model, its predictive rules are more accurate and reproducible than other trees. The discovered regulatory signature suggests an effective procedure to figure out the efficacy of investigational herbal compounds on particular cells in the drug discovery process.

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Differential Effects of Wedelia chinensis on Human Glioblastoma Multiforme Cells

Cited by 6 publications

References 35 publications

Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells

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