Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats

Sadeghzadeh, Fatemeh; Namvar, Parastoo; Naghavi, Farzaneh Sadat; Haghparast, Abbas

doi:10.1016/j.pbb.2015.12.005

Cited by 23 publications

(10 citation statements)

References 41 publications

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“…The mNAsh also promotes different forms of reinstatement (Anderson et al, 2008), including for alcohol (Chaudhri et al, 2010; Marchant et al, 2015), although, under conditions of extinction, inhibiting the mNAsh promotes relapse for alcohol (Millan et al, 2010). However, cortical activation of the mNAsh promotes reinstatement of opiate conditioned place preference (CPP) (Hearing et al, 2016) and seeking (Bossert et al, 2015), and OXRs within the mNAsh also contribute to expression and reinstatement of morphine CPP (Qi et al, 2013; Sadeghzadeh et al, 2016). Thus, although the mNAsh contribution can vary depending on the addictive behavior, these studies overall concur with our findings that OX1Rs in the mNAsh promote alcohol drinking in vivo and increase neuronal activity ex vivo (see below).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, OxA infusion within the mNAsh enhances feeding, which is prevented by SB, while OxA enhancement of locomotion is not prevented by SB (Thorpe and Kotz, 2005), indicating that SB can impact some but not all effects of OxA within the mNAsh, the remainder presumably reflecting action through OX2Rs. Also, development of morphine CPP is inhibited by SB but not OX2R inhibitors in the mNAsh (Sadeghzadeh et al, 2016). Finally, other studies have provided ex vivo evidence for functional OX1Rs within the mNAsh (Patyal et al, 2012), in addition to our demonstration of OX1R-dependent enhancement of mNAsh firing; we believe that these electrophysiological measures provide the most sensitive and direct method to assess the presence of functional receptors, in this case OX1Rs.…”

Section: Discussionmentioning

confidence: 99%

“…We recently demonstrated that projections from the anterior insula (aINS) to the nucleus accumbens (NAc) are critical for driving compulsion-like alcohol drinking in rats (Seif et al, 2013). The medial Shell subregion of the NAc (mNAsh) also plays an important role in a promoting a number of addictive and other motivated behaviors (Anderson et al, 2008; Chaudhri et al, 2010; Saddoris et al, 2013; Castro et al, 2015; Corbit and Balleine, 2015; Marchant et al, 2015; Millan et al, 2015), including a role for mNAsh OXRs during feeding and morphine-related behavior (Thorpe and Kotz, 2005; Qi et al, 2013; Sadeghzadeh et al, 2016), although there have been mixed results regarding the presence of OX1Rs within the mNAsh (See Section Discussion). The aINS is also thought to play a central role in driving addictive behaviors in both humans (Naqvi et al, 2014) and animals (Hollander et al, 2008; Seif et al, 2013), and OX1Rs within the aINS promote nicotine intake (Hollander et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Lei

Wegner

et al. 2016

Front. Neurosci.

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Addiction to alcohol remains a major social and economic problem, in part because of the high motivation for alcohol that humans exhibit and the hazardous binge intake this promotes. Orexin-1-type receptors (OX1Rs) promote reward intake under conditions of strong drives for reward, including excessive alcohol intake. While systemic modulation of OX1Rs can alter alcohol drinking, the brain regions that mediate this OX1R enhancement of excessive drinking remain unknown. Given the importance of the nucleus accumbens (NAc) and anterior insular cortex (aINS) in driving many addictive behaviors, including OX1Rs within these regions, we examined the importance of OX1Rs in these regions on excessive alcohol drinking in C57BL/6 mice during limited-access alcohol drinking in the dark cycle. Inhibition of OX1Rs with the widely used SB-334867 within the medial NAc Shell (mNAsh) significantly reduced drinking of alcohol, with no effect on saccharin intake, and no effect on alcohol consumption when infused above the mNAsh. In contrast, intra-mNAsh infusion of the orexin-2 receptor TCS-OX2-29 had no impact on alcohol drinking. In addition, OX1R inhibition within the aINS had no effect on excessive drinking, which was surprising given the importance of aINS-NAc circuits in promoting alcohol consumption and the role for aINS OX1Rs in driving nicotine intake. However, OX1R inhibition within the mPFC did reduce alcohol drinking, indicating cortical OXR involvement in promoting intake. Also, in support of the critical role for mNAsh OX1Rs, SB within the mNAsh also significantly reduced operant alcohol self-administration in rats. Finally, orexin ex vivo enhanced firing in mNAsh neurons from alcohol-drinking mice, with no effect on evoked EPSCs or input resistance; a similar orexin increase in firing without a change in input resistance was observed in alcohol-naïve mice. Taken together, our results suggest that OX1Rs within the mNAsh and mPFC, but not the aINS, play a central role in driving excessive alcohol drinking.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Lei

Wegner

et al. 2016

Front. Neurosci.

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“…These systems include neuronal projections from DAergic cell in the ventral tegmental area (VTA) to the nucleus accumbens (NAc) that is found by a predominant localization of DA D2 receptors (Gerfen, ; Koob and Bloom, ; Missale et al, ). The growing evidence has shown that DAergic receptors within the NAc are found to be crucial in the rewarding response of opiates, drug‐ and stress‐induced reinstatement of drug seeking (Ikemoto and Panksepp, ; Sadeghzadeh et al, ; Zhang et al, ). Several lines of evidence also have suggested that the reinstatement of drug‐seeking behaviors is mediated by DA receptors (Dai et al, ; Gilbert et al, ; Ma et al, ; See et al, ).…”

Section: Introductionmentioning

confidence: 99%

Food deprivation facilitates reinstatement of morphine‐induced conditioned place preference: Role of intra‐accumbal dopamine D2‐like receptors in associating reinstatement of morphine CPP with stress

Sadeghzadeh

Babapour

Haghparast

2017

Synapse

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The high rate of relapse to drug use is one of the main problems in the treatment of addiction. Stress plays the essential role in drug abuse and relapse; nevertheless, little is known about the mechanisms underlying stress and relapse. Accordingly, the effects of intra-accumbal administration of Sulpiride, as a dopamine D2-like receptor antagonist, on an ineffective morphine dose + food deprivation(FD)- and morphine priming-induced reinstatement of conditioned place preference (CPP). About 104 adult male albino Wistar rats weighing 200-280 g were bilaterally implanted by cannula into the nucleus accumbens (NAc). Subcutaneous (sc) injection of morphine (5 mg kg ) was used daily during a 3-day conditioning phase. After a 24-hr "off" period following achievement of extinction criterion, rats were tested for FD- and priming-induced reinstatement of morphine CPP by an ineffective (0.5 mg kg , sc) and priming (1 mg kg , sc) dose of morphine, respectively. In the next experiments, animals received different doses of intra-accumbal Sulpiride (0.25, 1, and 4 µg/0.5 µL saline) bilaterally and were subsequently tested for morphine reinstatement. Our findings indicated that the 24-hr FD facilitated reinstatement of morphine CPP. Furthermore, the D2-like receptor antagonist attenuated the ineffective morphine dose+ FD- and priming-induced reinstatement of morphine CPP dose-dependently. Also, contribution of D2-like receptors in mediation of the ineffective morphine dose+ FD-induced reinstatement of CPP was greater than morphine priming-induced reinstatement of CPP. The role of dopaminergic system in morphine reinstatement through a neural pathway in the NAc provides the evidence that D2-like receptor antagonist can be useful therapeutic targets for reinstatement of morphine CPP.

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“…However, future studies are needed to identify the mechanisms for this regulation. Nevertheless, mPFC, nucleus accumbens and VTA are important brain regions for drug addiction (Shah and Treit, 2004; Jasinska et al, 2014; Rosen et al, 2015; Sadeghzadeh et al, 2016); whereas hippocampus is a critical brain region for learning and memory. These results may not mean that learning and memory are not involved in morphine addiction but suggest that EAAT3 among many factors in the hippocampus may not be important for morphine addiction.…”

Section: Discussionmentioning

confidence: 99%

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

Wan

et al. 2017

Neuroscience

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Glutamate transporters (EAAT) have been implicated in the drug addiction behavior. We determined whether EAAT type 3 (EAAT3) played a role in morphine addiction. Six- to eight-week old EAAT3 knockout (EAAT3−/−) mice and their wild-type littermates received 3 intraperitoneal injections of 10 mg/kg morphine, each on an alternative day, to induce conditioned place preference (CPP). Two days after the place preference returned to baseline, mice received 2.5 mg/kg morphine to induce reinstatement. Some mice received intraperitoneal injection of 4 mg/kg riluzole, an EAAT activator, 30 min before morphine or saline injection. Hippocampus, medial prefrontal cortex, nucleus accumbens and ventral tegmental area were harvested for Western analysis 24 h after the last dose of morphine was injected. Morphine induced CPP in wild-type and EAAT3−/− mice. Gender is not a statistically significant factor to influence this behavior. This conditioned behavior extinguished after morphine administration was stopped for 8 to 9 days in wild-type mice, while this extinction occurred 6 days after discontinuation of morphine injection in EAAT3−/− mice. A small dose of morphine similarly reinstated the conditioned behavior in the wild-type and EAAT3−/− mice. Riluzole abolished morphine-induced CPP during the initial place preference. Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. These results suggest that EAAT3 delays the extinction of morphine-induced CPP. EAAT activation may prevent the formation of morphine-induced CPP.

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Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats

Cited by 23 publications

References 41 publications

Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Food deprivation facilitates reinstatement of morphine‐induced conditioned place preference: Role of intra‐accumbal dopamine D2‐like receptors in associating reinstatement of morphine CPP with stress

Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference

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