Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice

Sakurada, Tsukasa; Matsumura, Toshihiro; Moriyama, Toshiyuki; Sakurada, Chikai; Ueno, Shinji; Sakurada, Shinobu

doi:10.1016/s0091-3057(03)00066-2

Cited by 78 publications

(51 citation statements)

References 50 publications

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“…The capsaicin-induced paw licking test is an experimental model used for the investigation of substances that act on pain of a neurogenic origin (Sakurada et al, 2003). In the present study, it was demonstrated that capsaicin-evoked nociceptive pain behaviours were significantly attenuated in mice treated with HFTP in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 54%

“…Capsaicin, a pungent ingredient of red peppers, is well known to stimulate a ligand-gated cation channel, the vanilloid receptor (transient receptor potential cation channel V1 or TRPV1) located on poly-modal C-fibres of nociceptive sensory neurons (Schmidt, 2002). Stimulation of these receptors initiates a complex cascade of events, including neuronal excitation, release of excitatory amino acids, nitric oxide and pro-inflammatory mediators (Sakurada et al, 2003). In a similar experimental condition, it was also observed that capsazepine, a selective capsaicin receptor antagonist, significantly reduced the nociception induced by capsaicin.…”

Section: Discussionmentioning

confidence: 76%

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Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

Suloon¹,

Mohamad²,

Lee³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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The current study was conducted to further examine the antinociceptive activity of hexane fraction of turmeric powder (HFTP) and to elucidate the possible mechanisms of action underlying its antinociceptive activity in various experimental models of chemical-and thermal-induced nociception. Materials and Methods: Acetic acid-induced abdominal constriction, hot-plate, formalin-, capsaicin-and glutamate-induced paw licking tests in mice were employed in the antinociceptive investigation of HFTP. In all experiments, HFTP was administered intraperitoneally at the doses of 0.1, 0.5, 1.0 and 5.0 mg/kg. In a separate group of experiments, the possible sedative and toxic effects of HFTP were tested in rota rod and preliminary acute toxicity tests, respectively. Results: It was demonstrated that HFTP exerted significant dose-dependent antinociceptive responses in the acetic acid-induced abdominal constriction, hot-plate, formalin-, capsaicin-and glutamate-induced paw licking tests. It was also demonstrated that pretreatment with naloxone, produced no significant effect on the antinociception induced by HFTP. Moreover, administration of HFTP shows no significant interference in locomotor activity of the rota rod test, and in the preliminary acute toxicity test, neither abnormal behaviours nor mortality were observed. Conclusion: Together, these results indicated that HFTP-induced antinociceptive activity at doses devoid of any detectable toxicity and sedative effects exerts pronounced peripheral and central antinociceptive effects, with no involvement of opioidergic system but possibly related to its ability to interact with TRPV1 receptors and the glutamatergic system.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 76%

Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

Suloon¹,

Mohamad²,

Lee³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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show abstract

“…TPN produced an inhibition of the nociception induced by glutamate (Table 2). Sakurada et al (2003) proposed the capsaicin-induced pain model for the study of compounds that act on pain of neurogenic origin. Capsaicin is a neurotoxic compound extracted from red pepper which, when applied to the skin or injected into animals, produces irritation, a painful reaction, and subsequent desensitization to chemically induced pain.…”

Section: Resultsmentioning

confidence: 99%

α-Terpineol reduces nociceptive behavior in mice

Quintans‐Júnior

Oliveira

Santana

et al. 2011

Pharmaceutical Biology

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“…Sakurada et al [47] proposed the capsaicin-induced pain model for the study of compounds that act on pain of neurogenic origin. Capsaicin is a neurotoxic compound extracted from red pepper which, when applied to the skin or injected into animals, produces irritation, a painful reaction, and subsequent desensitization to chemically-induced pain [24].…”

Section: Discussionmentioning

confidence: 99%

Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

Guimarães

Oliveira

Melo

et al. 2010

Basic Clin Pharma Tox

194

135

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We examined the antioxidant properties in vitro and the antinociceptive effect of carvacrol (CARV) in several models of pain in mice. CARV presented a strong antioxidant potential according to the TRAP ⁄ TAR evaluation; it also presented scavenger activity against nitric oxide and prevented lipid peroxidation in vitro. In mice, when evaluated against acetic acidinduced abdominal writhing, CARV (25, 50 and 100 mg ⁄ kg, i.p.) reduced (p < 0.001) the number of writhing compared to the control group, without opioid participation. In the formalin test, CARV also significantly inhibited both the early (neurogenic pain) and the late (inflammatory pain) phases of formalin-induced licking, with inhibition percentage values of 56.8% (100 mg ⁄ kg) for the neurogenic phase and 41.2% (25 mg ⁄ kg), 73.8% (50 mg ⁄ kg) and 99.7% (100 mg ⁄ kg) for the inflammatory phase. CARV also produced a significant inhibition of the pain caused by capsaicin (63.1, 67.1 and 95.8%, p < 0.001) and glutamate (46.4, 61.4 and 97.9%, p < 0.01). When assessed in a thermal model of pain, CARV (100 mg ⁄ kg, i.p.) caused a significant increase (p < 0.05) in the latency response on the hot-plate test. Such results were unlikely to be provoked by motor abnormality. Together, these results indicate that the properties of CARV should be more thoroughly examined in order to achieve newer tools for management and ⁄ or treatment of painful conditions, including those related to pro-oxidant states.

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Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice

Cited by 78 publications

References 50 publications

Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

α-Terpineol reduces nociceptive behavior in mice

Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

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