Differential Effects of Irradiation with Carbon Ions and X-Rays on Macrophage Function

Conrad, Sandro; Ritter, S.; Fournier, Claudia; Nixdorff, Kathryn

doi:10.1269/jrr.08115

Cited by 28 publications

(21 citation statements)

References 44 publications

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“…Myeloid cells, such as macrophages, neutrophils, DCs, eosinophils, and monocytes, are considered to be more radioresistant in contrast to lymphoid cells (31,32). Our present study partly confirms these findings ( Figure 2B, bottom).…”

Section: The Cd8supporting

confidence: 88%

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

et al. 2016

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Section: The Cd8supporting

confidence: 88%

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

et al. 2016

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“…Using RAW264.7 macrophages, a non-linearity in IL-1β production was observed after high-linear energy transfer (LET) carbon ion radiation (Conrad et al, 2009). Notably, as compared to other inflammatory cytokines, expression of IL-1β is tightly regulated by a three step process and requires two distinct stimuli (Tschopp et al, 2003).…”

Section: Modulatory Properties On Macrophages and Dcs Of Low-dose Irrmentioning

confidence: 99%

Immunomodulatory Properties and Molecular Effects in Inflammatory Diseases of Low-Dose X-Irradiation

Rödel¹,

Frey²,

Manda³

et al. 2012

Front. Oncol.

100

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Inflammatory diseases are the result of complex and pathologically unbalanced multicellular interactions. For decades, low-dose X-irradiation therapy (LD-RT) has been clinically documented to exert an anti-inflammatory effect on benign diseases and chronic degenerative disorders. By contrast, experimental studies to confirm the effectiveness and to reveal underlying cellular and molecular mechanisms are still at their early stages. During the last decade, however, the modulation of a multitude of immunological processes by LD-RT has been explored in vitro and in vivo. These include leukocyte/endothelial cell adhesion, adhesion molecule and cytokine/chemokine expression, apoptosis induction, and mononuclear/polymorphonuclear cell metabolism and activity. Interestingly, these mechanisms display comparable dose dependences and dose-effect relationships with a maximum effect in the range between 0.3 and 0.7 Gy, already empirically identified to be most effective in the clinical routine. This review summarizes data and models exploring the mechanisms underlying the immunomodulatory properties of LD-RT that may serve as a prerequisite for further systematic analyses to optimize low-dose irradiation procedures in future clinical practice.

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“…First investigations with latex beads as prey revealed that low dose X-irradiation of LPS-activated macrophages reduces the phagocytosis. In contrast, higher single-doses (≥5 Gy) slightly increase the uptake of beads by activated macrophages (Conrad et al, 2009). The phagocytosis of colorectal tumor cells by macrophages and dendritic cells was shown to be reduced when the tumor cells (and not the macrophages) had been irradiated with higher doses of X-ray (2, 5, or 10 Gy).…”

Section: Immune Modulation By Low and Intermediate Dose Radiationmentioning

confidence: 99%

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?

Rubner¹,

Wunderlich²,

Rühle³

et al. 2012

Front. Oncol.

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Radiotherapy (RT) with ionizing irradiation is commonly used to locally attack tumors. It induces a stop of cancer cell proliferation and finally leads to tumor cell death. During the last years it has become more and more evident that besides a timely and locally restricted radiation-induced immune suppression, a specific immune activation against the tumor and its metastases is achievable by rendering the tumor cells visible for immune attack. The immune system is involved in tumor control and we here outline how RT induces anti-inflammation when applied in low doses and contributes in higher doses to the induction of anti-tumor immunity. We especially focus on how local irradiation induces abscopal effects. The latter are partly mediated by a systemic activation of the immune system against the individual tumor cells. Dendritic cells are the key players in the initiation and regulation of adaptive anti-tumor immune responses. They have to take up tumor antigens and consecutively present tumor peptides in the presence of appropriate co-stimulation. We review how combinations of RT with further immune stimulators such as AnnexinA5 and hyperthermia foster the dendritic cell-mediated induction of anti-tumor immune responses and present reasonable combination schemes of standard tumor therapies with immune therapies. It can be concluded that RT leads to targeted killing of the tumor cells and additionally induces non-targeted systemic immune effects. Multimodal tumor treatments should therefore tend to induce immunogenic tumor cell death forms within a tumor microenvironment that stimulates immune cells.

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Differential Effects of Irradiation with Carbon Ions and X-Rays on Macrophage Function

Cited by 28 publications

References 44 publications

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Immunomodulatory Properties and Molecular Effects in Inflammatory Diseases of Low-Dose X-Irradiation

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?

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