Differential effects of levodopa and apomorphine on neuronal population oscillations in the cortico-basal ganglia loop circuit in vivo in experimental parkinsonism

Kühn, Johanna; Haumesser, Jens K.; Beck, Maximilian Heinz; Altschüler, Jennifer; Kühn, Andrea A.; Nikulin, Vadim V.; Riesen, Christoph van

doi:10.1016/j.expneurol.2017.09.005

Cited by 21 publications

(11 citation statements)

References 62 publications

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“…To further confirm the beta oscillations, L-dopa, which is widely used in PD patient therapy and therapeutic studies in the PD rat model, was injected into the abdomen in the PD rat model (40 mg/kg body weight), and continuous data were recorded 40 min after injection. As shown in Figure 3c, the beta peak was removed, which demonstrated that the beta oscillation was eliminated by L-dopa, which is consistent with previous work [26,30,31].…”

Section: The Self-designed Recording Electrode Successfully Acquires supporting

confidence: 91%

A novel low-cost electrode for recording the local field potential of freely moving rat’s brain

Ding

Gao

Zhang

et al. 2020

Translational Neuroscience

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AbstractLocal field potentials (LFPs) are involved in almost all cognitive activities of animals. Several kinds of recording electrodes are used for recording LFPs in freely moving animals, including commercial and homemade electrodes. However, commercial recording electrodes are expensive, and their relatively fixed size often causes a steric hindrance effect, especially when combining deep brain stimulation (DBS) with LFP recording, which may not always satisfy the aim of researchers. Currently, an increasing number of researchers are designing their own recording electrodes to lower research costs. Nevertheless, there is no simple universal method to produce low-cost recording electrodes with a specific size according to the target brain area. Thus, we developed a simple method for quickly producing low-cost multiple-channel recording electrodes. To inspect the effectiveness of our self-designed electrode, LFPs were recorded in a Parkinson’s disease (PD) rat model, and an electrical stimulation electrode was implanted into the subthalamic nucleus to verify the space-saving ability of the self-designed recording electrode. The results showed that <30 min was needed to prepare an electrode and that the electrode materials cost <5 dollars. Further investigations showed that our electrode successfully recorded the beta oscillations (12–40 Hz) in the PD rat model. Thus, this method will greatly reduce the cost of recording electrodes and save time for researchers. Additionally, the small size of the electrode will further facilitate DBS research.

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Section: The Self-designed Recording Electrode Successfully Acquires supporting

confidence: 91%

A novel low-cost electrode for recording the local field potential of freely moving rat’s brain

Ding

Gao

Zhang

et al. 2020

Translational Neuroscience

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“…The pharmacotherapy of PD is primarily based on two classes of drugs: dopamine precursors, (levodopa) and dopamine receptor agonists (apomorphine) and both therapies reduces the beta-band activity. However, levodopa is more effective in modulating beta-band power compared to other drugs (Kuhn et al, 2017). In MPTPtreated NHP models, abnormal oscillations in the basal-ganglia network was more prominent in the lower frequency bands (<13 Hz) compared to PD patients (Devergnas et al, 2014).…”

Section: Discussionmentioning

confidence: 93%

Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates

Singh

Papa

2019

Preprint

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Dopamine depletion in Parkinson's disease (PD) is associated with abnormal oscillatory activity in the cortico-basal ganglia network. However, the oscillatory pattern of striatal neurons in PD remains poorly defined. Here, we analyzed the local field potentials in one untreated and five MPTP-treated non-human primates (NHP) to model advanced PD. Augmented oscillatory activity in the alpha (8-13 Hz) and low-beta (13-20 Hz) frequency bands was found in the striatum in parallel to the motor cortex and globus pallidus of the NHP-PD model. The coherence analysis showed increased connectivity in the cortico-striatal and striato-pallidal pathways at alpha and low-beta frequency bands, confirming the presence of abnormal 8-20 Hz activity in the cortico-basal ganglia network. The acute L-Dopa injection that induced a clear motor response normalized the amplified 8-20 Hz oscillations. These findings indicate that pathological striatal oscillations at alpha and low-beta bands are concordant with the basal ganglia network changes after dopamine depletion, and thereby support a key role of the striatum in the generation of parkinsonian motor abnormalities.

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“…On average, LD strongly suppressed beta activity (Off LD: 4.3 ± 0.9 AUC, On LD: 2.4 ± 0.9 AUC, P < 0.001; Supplementary Figure S2B), as previously shown by us and others. 27,33 Levodopa Leads to a Progressive Increase in AIMs Thirty-one days after the 6-OHDA lesion, the animals were treated once daily with LD for 3 weeks. At days 1, 4, 10, 16, and 21, we recorded M1 ECoG as well as videotaped motor behavior.…”

Section: Levodopa Suppresses Cortical Beta Powermentioning

confidence: 99%

Levodopa‐Induced Dyskinesia Are Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism

et al. 2020

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Background Levodopa is the most efficacious drug in the symptomatic therapy of motor symptoms in Parkinson's disease (PD); however, long‐term treatment is often complicated by troublesome levodopa‐induced dyskinesia (LID). Recent evidence suggests that LID might be related to increased cortical gamma oscillations. Objective The objective of this study was to test the hypothesis that cortical high‐gamma network activity relates to LID in the 6‐hydroxydopamine model and to identify new biomarkers for adaptive deep brain stimulation (DBS) therapy in PD. Methods We recorded and analyzed primary motor cortex (M1) electrocorticogram data and motor behavior in freely moving 6‐OHDA lesioned rats before and during a daily treatment with levodopa for 3 weeks. The results were correlated with the abnormal involuntary movement score (AIMS) and used for generalized linear modeling (GLM). Results Levodopa reverted motor impairment, suppressed beta activity, and, with repeated administration, led to a progressive enhancement of LID. Concurrently, we observed a highly significant stepwise amplitude increase in finely tuned gamma (FTG) activity and gamma centroid frequency. Whereas AIMS and FTG reached their maximum after the 4th injection and remained on a stable plateau thereafter, the centroid frequency of the FTG power continued to increase thereafter. Among the analyzed gamma activity parameters, the fraction of longest gamma bursts showed the strongest correlation with AIMS. Using a GLM, it was possible to accurately predict AIMS from cortical recordings. Conclusions FTG activity is tightly linked to LID and should be studied as a biomarker for adaptive DBS. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

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Differential effects of levodopa and apomorphine on neuronal population oscillations in the cortico-basal ganglia loop circuit in vivo in experimental parkinsonism

Cited by 21 publications

References 62 publications

A novel low-cost electrode for recording the local field potential of freely moving rat’s brain

A novel low-cost electrode for recording the local field potential of freely moving rat’s brain

Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates

Levodopa‐Induced Dyskinesia Are Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism

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