Differential Effects of Lipopolysaccharide on Pup Retrieving and Nest Building in Lactating Mice

Aubert, Arnaud; Goodall, Glyn; Dantzer, Robert; Gheusi, Gilles

doi:10.1006/brbi.1997.0485

Cited by 185 publications

(137 citation statements)

References 28 publications

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“…Furthermore, lactating female rats reduce nest-building behavior and decrease activity after LPS injection at mild ambient temperatures. However, females cease to exhibit sickness behavior when exposed to cold temperatures that could potentially threaten survival of their pups (Aubert et al, 1997). These studies support the idea that suppression of sickness behavior should occur during winter, when temperatures are colder, instead of the spring.…”

Section: Temperaturesupporting

confidence: 66%

“…Because food intake is suppressed, protein, lipid and carbohydrate stores are mobilized internally to fuel the energetic costs of inflammation and fever. In addition to these metabolic costs, expression of sickness behavior interferes with reproduction (Kent et al, 1992;Konsman et al, 2002) and associated activities such as territorial aggression and maintenance (Owen-Ashley et al, 2006), sexual behavior (Yirmiya et al, 1995) and parental care (Aubert et al, 1997). These reproductive activities are suppressed in favor of increased sleep for recruitment of additional resources to combat infection (Kent et al, 1992;Dantzer, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)

Owen-Ashley

Wingfield

2006

Journal of Experimental Biology

112

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SUMMARY A variety of vertebrate species modulate immune function on a seasonal basis to cope with seasonal energy deficits and competing life-history demands, such as reproduction. Most studies to date have focused upon seasonal variation of cellular and humoral immunity, while neglecting behavioral responses to infection. These behavioral strategies are collectively termed sickness behaviors and are hypothesized to divert energy away from normal activities to combat and overcome infection. Sickness behavior can be triggered experimentally by injecting bacterial lipopolysaccharide (LPS). In this study, we provide the first evidence for seasonal modulation of sickness behavior in a free-living animal. Male song sparrows of western Washington state (Melospiza melodia morphna) are sedentary and territorial year round, except for a brief time during molt. Treatment with LPS decreased territorial aggressive behavior of males in the winter (nonbreeding), but not in the spring (breeding). Subjects were recaptured approx. 25 h after treatment. Recaptured LPS males in the winter lost more body mass than saline-injected controls while LPS males in the spring did not. These data indicate that birds in breeding condition were relatively insensitive to the effects of LPS. On a proximate level, suppression of sickness behavior during breeding is likely mediated by seasonal differences in energy allocation, as wintering sparrows were significantly heavier and had larger subcutaneous fat reserves and lower baseline corticosterone levels than breeding birds. Ultimately, suppression of sickness behavior may represent an allocation strategy to balance current reproductive opportunities with the life-history costs of self-defense.

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Section: Temperaturesupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)

Owen-Ashley

Wingfield

2006

Journal of Experimental Biology

112

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“…Mice experiencing a general malaise have been found to engage in little to no nest building behavior when forced to build a nest 14 .…”

Section: Sicknessmentioning

confidence: 99%

Nest Building as an Indicator of Health and Welfare in Laboratory Mice

Gaskill

Karas

Garner

et al. 2013

JoVE

135

112

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The minimization and alleviation of suffering has moral and scientific implications. In order to mitigate this negative experience one must be able to identify when an animal is actually in distress. Pain, illness, or distress cannot be managed if unrecognized. Evaluation of pain or illness typically involves the measurement of physiologic and behavioral indicators which are either invasive or not suitable for large scale assessment.The observation of nesting behavior shows promise as the basis of a species appropriate cage-side assessment tool for recognizing distress in mice. Here we demonstrate the utility of nest building behavior in laboratory mice as an ethologically relevant indicator of welfare. The methods presented can be successfully used to identify thermal stressors, aggressive cages, sickness, and pain. Observation of nest building behavior in mouse colonies provides a refinement to health and well-being assessment on a day to day basis.

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“…Immediately following injections, females were returned to their cages and paired with a novel, naive male for 2 h. Two hours postinjection, males were returned to their home cages, and all females were taken to a separate room for bleeding. This time was selected because it coincides with the period of maximum physiological effects of LPS [17,32]. Animals were lightly anesthetized with methoxyflurane vapors (Metofane, Schring-Plough, Union, NJ).…”

Section: Steroid Hormone Riamentioning

confidence: 99%

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

DeVries

et al. 1999

Physiology & Behavior

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Differential Effects of Lipopolysaccharide on Pup Retrieving and Nest Building in Lactating Mice

Cited by 185 publications

References 28 publications

Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)

Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)

Nest Building as an Indicator of Health and Welfare in Laboratory Mice

Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

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