Differential effects of luteolin and its glycosides on invasion and apoptosis in MDA-MB-231 triple-negative breast cancer cells

Lee, Jiyon; Park, Su-Ho; Lee, Jintak; Chun, Hyun-Woo; Choi, Myoung-Kwon; Yoon, Jae-Hwan; Pham, Thu-Huyen; Kim, Ki Hong; Kwon, Taeho; Ryu, Hyung Won; Oh, Sei‐Ryang; Yoon, Do‐Young

doi:10.17179/excli2019-1459

Cited by 13 publications

(4 citation statements)

References 39 publications

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“… 10 In vitro studies show higher cytotoxicity of flavonoid aglycones when compared with glycosides. 11 In addition indeed, alcohol extracts from silver birch leaves were shown to exert low cytotoxicity in glioma, breast cancer and epidermoid carcinoma cells. 12 However, flavonoids contained in birch extracts were reported to efficiently induce cancer cell death by various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Szoka

Nazaruk

Stocki

et al. 2021

J Cellular Molecular Medi

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Numerous studies provide evidence for the potential beneficial effect of flavonoids in cancer chemoprevention and inducing cancer cell death. 1,2 Flavonoids are low molecular weight, secondary plant metabolites characterized by a benzoγ-pyrone core. This broad class of phenolics contains over 4000 compounds. 3 Due to their wide distribution in the leaves, flowers, fruits, bark and seeds of plants, flavonoids are part of human diet and herbal medicine. Flavonoids occur in plant cells primarily as glycosides and polymers that need to be degraded before absorption. 4 Hydrolysis of flavonoid glycosides is catalysed by small intestine hydrolases and human intestinal microflora. Absorbed aglycones are metabolized by glucuronidation, sulfation and O-methylation in enterocytes, or transported with subsequent conjugation in the liver. Consequently, orally administered flavonoids reach the highest concentration and thus exert the most potent effect in the digestive tract and liver. Downy birch (Betula pubescens Ehrh.) and silver birch (Betula pendula Roth) are deciduous trees characterized by their silver-white bark.Downy birch commonly grows in Europe and northern Asia, particularly in damp soils, while silver birch prefers less moist soils. 5 Dried fresh leaves of both birch species are used in Polish traditional medicine as a diuretic. 6 The major constituents of the leaves that probably cause the diuretic effect are flavonoids, hyperoside and other

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Section: Introductionmentioning

confidence: 99%

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Szoka

Nazaruk

Stocki

et al. 2021

J Cellular Molecular Medi

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“…Luteolin 7-O-β-d-glucopyranoside shows an inhibitory effect to lactate dehydrogenase in humans by interacting with the enzyme’s active site. [ 47 ] Luteolin, either aglycone or glycoside, has many biological activities, including: antimicrobial,[ 48 ] antioxidant,[ 49 ] anti-inflammatory activity,[ 50 ] anticancer,[ 51 ] monoamine oxidase inhibition,[ 52 ] inhibitory effects on lens aldose reductase,[ 53 ] and antiplatelet effects. [ 54 ] Luteolin also has multiple cardioprotective effects by enhancing contractility, upregulating autophagy, and preventing cardiac fibrosis[ 55 ] and anti–HIV-1 activity.…”

Section: R Esults and Discussionmentioning

confidence: 99%

Pimpinella pruatjan Molk: LC-MS/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts

Timotius

Rahayu

Nurcahyanti

2023

Journal of Pharmacy and Bioallied Sciences

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Pimpinella pruatjan Molk is native to Java and well known as aphrodisiac in traditional medicine. A water-boiled extract of the plant has been used in the treatment of erectile dysfunction (ED). No study has been found on the phytochemical constituents and identification of corresponding biological activities in water and polar extract. This study is aimed to identify phytoconstituents of a decoction and ethanol extract from the aerial parts of P. pruatjan Molk. Liquid chromatography-tandem mass spectroscopy (LC-MS/MS) was used to analyze and predict the bioactive compounds in both extracts. LC-MS/MS revealed both extracts contained two important compounds: Luteolin-7-O-β-D glucopyranoside and Undulatoside A. Luteolin and Luteolin glucoside are also found in P.anisum L. Lutein 7-O glucoside was found in water extract, while more bioactive compounds, including populnin, 3,5-O-dicaffeoylquinic acid, quercetin-3’- O glucoside, methylophiopogononeone-A, kaempferol-7-O-α-L-arabinofuranoside, and 7-hydroxy-3,5,6,3’,4’- pentamethoxyflavone, were found in ethanol extract. Accumulation of flavonoids, phenols, phenylpropanoids, alkaloids, and furanochromone in low quantities was observed in both extracts. This is the first report providing evidence justifying its use as a traditional medicine. Further investigation into the pharmacology mechanism of action is required.

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“…There are few such studies about the mechanism beta-sitosterol on MDA-MB-231; only few articles had shown that it induces cell apoptosis [ 20 , 26 ]. Luteolin could enhance paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3 [ 27 ]. Most of the existing studies focus on the mechanism of TCM monomers enhancing the efficacy of chemotherapy for breast cancer, partly because of the poor tumor suppressive effect of TCM monomers in mice, and on the other hand, TCM monomers are in the early stage of basic research and cannot be applied in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Study on Mechanism of Yiqi Yangyin Jiedu Recipe Inhibiting Triple Negative Breast Cancer Growth: A Network Pharmacology and In Vitro Verification

Sun

Zhang

et al. 2022

Journal of Oncology

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Background. The present study explores the potential mechanism of Yiqi yangyin jiedu Recipe (YQYYJDR) on triple negative breast cancer via adopting network pharmacology and experimental validation. Materials and Methods. The potential active compounds and target genes of YQYYJDR were screened out from TCMSP database with OB ≥ 30 % and DL index ≥ 0.18 . The potential pathways and function enrichment were identified from Metascape website. MDA-MB-231 and MDA-MB-468 cells were tested for cell viability, invasion, and apoptosis by in vitro and in vivo experiments. Results. A total of 153 bioactive compounds and 281 target genes of YQYYJDR were retrieved from TCMSP database. The top 5 enrichment pathways of YQYYJDR target genes include pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, proteoglycans in cancer, IL-17 signaling pathway, and platinum drug resistance. 65 target genes were included in the pathway of cancer. Biological function enrichment analysis of 65 genes showed YQYYJDR inhibited tumor growth mainly through apoptotic pathway. In vitro experiments showed that YQYYJDR could inhibit the proliferation and invasion of MDA-MB-231 and MDA-MB-468 cells, arrest cells in S stage, and induce cell apoptosis. YQYYJDR upregulated BAX, caspase3, and cleaved caspase3 expression and downregulated BCL2 expression. In vivo experiments showed that YQYYJDR could inhibit tumor growth. Conclusions. In this study, network pharmacology and experiment were used to explore the mechanism of YQYYJDR on triple negative breast cancer. In vitro and in vivo experiments showed that YQYYJDR could inhibit the growth of triple negative breast cancer and induce cell apoptosis. Apoptosis pathway plays a significant role in the treatment of triple negative breast cancer.

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Differential effects of luteolin and its glycosides on invasion and apoptosis in MDA-MB-231 triple-negative breast cancer cells

Cited by 13 publications

References 39 publications

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Pimpinella pruatjan Molk: LC-MS/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts

Study on Mechanism of Yiqi Yangyin Jiedu Recipe Inhibiting Triple Negative Breast Cancer Growth: A Network Pharmacology and In Vitro Verification

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