1976
DOI: 10.1016/0024-3205(76)90205-8
|View full text |Cite
|
Sign up to set email alerts
|

Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
32
0

Year Published

1978
1978
2011
2011

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 83 publications
(33 citation statements)
references
References 7 publications
1
32
0
Order By: Relevance
“…The behavioral studies using rats, antagonism of dopamine agonist-induced hyperlocomotion (Janssen et al, 1965;Ogren et al, 1984;Gustafsson and Christensson, 1990;Moore and Kenyon, 1994) and conditioned avoidance response (CAR) paradigm (Cook et al, 1955;Davidson and Weidley, 1976;Arnt, 1982; for review, see Wadenberg et al, 1999) have traditionally been used to predict the antipsychotic efficacy of novel agent. In the present study, YKP1447 dose-dependently inhibited d-amphetamine-induced hyperlocomotion activity in rats, indicating the antipsychotic action of YKP1447.…”
Section: Discussionmentioning
confidence: 99%
“…The behavioral studies using rats, antagonism of dopamine agonist-induced hyperlocomotion (Janssen et al, 1965;Ogren et al, 1984;Gustafsson and Christensson, 1990;Moore and Kenyon, 1994) and conditioned avoidance response (CAR) paradigm (Cook et al, 1955;Davidson and Weidley, 1976;Arnt, 1982; for review, see Wadenberg et al, 1999) have traditionally been used to predict the antipsychotic efficacy of novel agent. In the present study, YKP1447 dose-dependently inhibited d-amphetamine-induced hyperlocomotion activity in rats, indicating the antipsychotic action of YKP1447.…”
Section: Discussionmentioning
confidence: 99%
“…It is well established that low (noncataleptic) doses of all APDs, administered after the avoidance behavior has been acquired, selectively disrupt that avoidance response yet leave the escape response intact (Ader & Clink, 1957;Arnt, 1982;Cook & Weidley, 1957;Cook & Catania, 1964;Courvoisier, 1956b;Davidson & Weidley, 1976;Ponsluns, 1962). As the drug wears off, the avoidance response is restored (Wadenberg et al, 2001;Smith, Li, Becker, & Kapur, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…However, after several presentations of the CS-US pair, the animal typically runs during the CS and before the onset of the US, thereby avoiding the US altogether. Animals treated with low (noncataleptic) doses of APDs fail to perform avoidance responses to the CS, even though their escape response to the shock itself is relatively unaffected (Ader and Clink, 1957;Arnt, 1982;Cook and Catania, 1964;Cook and Weidley, 1957;Courvoisier, 1956;Davidson and Weidley, 1976;Ponsluns, 1962). This selective disruption of avoidance is characteristic of all APDs, but neither anxiolytics nor antidepressants show this effect (Courvoisier, 1956;Morpurgo, 1965;Reynolds and Czudek, 1995).…”
Section: Introductionmentioning
confidence: 99%