Differential effects of oestrogen in murine lupus: Acceleration of glomerulonephritis and amelioration of T cell-mediated lesions

Carlsten, Hans; Nilsson, Nicklas; Jönsson, Roland; Tarkowski, Andrej

doi:10.1016/0896-8411(91)90048-h

Cited by 34 publications

(16 citation statements)

References 24 publications

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“…Estrogens are known since at least twenty years to exert immunoregulatory properties, reviewed in [4,26,27]. We have proposed a dual effect of estradiol on immune reactivity as demonstrated by on one hand suppressive effect on T lymphocyte mediated DTH and stimulation of immunoglobulin production on the other [2,28]. This estrogen-mediated dichotomous impact on immunity results in suppression of T lymphocyte dependent diseases such as experimental collagen type II induced arthritis [29] and encephalomyelitis [30] whereas immune-complex mediated diseases such as murine SLE is aggravated [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice

1996

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Many immune-mediated inflammatory diseases are treated with corticosteroids. This type of treatment is, however, often afflicted with side-effects such as osteoporosis and atherosclerosis. During the last decades also sex steroids, such as estrogens, have been shown to have immunoregulatory properties. In this report we studied the effect of combined treatment with suboptimal doses of dexamethasone and estradiol on T lymphocyte mediated delayed type hypersensitivity (DTH), granulocyte-mediated inflammatory responses, immunoglobulin production and antigen specific antibody responses in mice. The results show that the two hormones display additive effects on suppression of DTH. In contrast, such additive effects were not observed in granulocyte-mediated inflammation. B lymphocyte activity, measured by immunoglobulin production and antigen-specific antibody responses, were increased after exposure to estradiol and suppressed by dexamethasone. In mice treated with both hormones the up regulation of B lymphocytes was still evident. The results could indicate the potential to use combinations of corticosteroids and estrogen in the treatment of T lymphocyte dependent rheumatic diseases such as rheumatoid arthritis (RA). In addition, the B lymphocyte stimulation by estrogen in cortisone exposed mice stimulate to future studies in humans if estrogen containing contraceptives or post menopausal hormone treatment could have triggering effects in patients with immune complex mediated diseases also when they are on corticosteroid treatment.

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Section: Discussionmentioning

confidence: 99%

Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice

1996

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“…In contrast, SLE is exacerbated during pregnancy and ameliorated post-partum [6]. Treatment with estrogens has yielded similar results where the administration of estrogen results in suppression of disease in humans and in animal models of MS, but exacerbation of disease in murine SLE [7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 95%

Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations

Phiel¹,

Henderson²,

Adelman³

et al. 2005

Immunology Letters

304

230

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“…In several studies it has been suggested that estrogen is an accelerator of the lupus disease of NZB/W mice [16,17]. Moreover, Carlsen and his co-works also found that estrogen was a potent disease accelerator; Estrogen accelerated immune complex glomerulonephritis but ameliorated T cell-mediated vasculitis and sialadenitis in autoimmune MRL/lpr mice [18][19][20]. Thus, estrogen has been shown to have a significant impact on the clinical course of certain human and experimental autoimmune diseases [18][19][20][21].…”

Section: Introductionmentioning

confidence: 91%

“…Moreover, Carlsen and his co-works also found that estrogen was a potent disease accelerator; Estrogen accelerated immune complex glomerulonephritis but ameliorated T cell-mediated vasculitis and sialadenitis in autoimmune MRL/lpr mice [18][19][20]. Thus, estrogen has been shown to have a significant impact on the clinical course of certain human and experimental autoimmune diseases [18][19][20][21]. Soy and soy-derived products include large quantities of isoflavones, which bind to the estrogen receptors (ER) and show potential estrogenic activity [22,23].…”

Section: Introductionmentioning

confidence: 93%

A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice

Zhao

Sun

Horiguchi

et al. 2005

International Immunopharmacology

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Differential effects of oestrogen in murine lupus: Acceleration of glomerulonephritis and amelioration of T cell-mediated lesions

Cited by 34 publications

References 24 publications

Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice

Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice

Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations

A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice

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