Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats

Fujii, Tomoko; Nonaka, Chizuru; Ikeda, H

doi:10.1016/0306-4530(84)90046-5

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Other studies suggest a sex dependence in the activity of GABAergic system, since many authors (Fujii et al, 1984;Pericik et al, 1985) have reported that male and female rats respond differentially to drugs affecting GABA transmission. Furthermore, it has been shown that in selected brain areas the levels of benzodiazepine binding sites, which have been described to be strictly linked to GABA receptors (Schoch et al, 1985), are significantly lower in the female than in the male rats (Shepard et d., 1982).…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in the Response of the GABAergic System to Estrogen Administration

Pérez

Zucchi

Maggi

1986

Journal of Neurochemistry

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Administration of estradiol benzoate to gonadectomized female rats results in up-regulation of CNS gamma-aminobutyric acid (GABA) receptors. The increase of [3H]muscimol binding activity is observed in six of the seven brain areas examined. The same treatment, performed in castrated male or androgenized female rats, induced an increase of [3H]muscimol binding only in the striatum. Evidence is provided suggesting that the dimorphic sensitivity of GABA receptor is not correlated with the difference in spontaneous motor activity reported between male and female rats.

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Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in the Response of the GABAergic System to Estrogen Administration

Pérez

Zucchi

Maggi

1986

Journal of Neurochemistry

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“…Changes in pituitary gonadotropin (LH and FSH) release or content, as observed in human patients, have also been documented in several rodent models of chronic epilepsy and acute seizure induction in both males and females (Bhanot and Wilkinson, 1982;Fujii et al, 1984;Amado and Cavalheiro, 1998), although changes in LH pulsatility patterns have not yet been tested in either sex. These changes appear to be at least partially due to paroxysmal activity in limbic structures, as several studies have shown changes in LH and/or FSH release following electrical stimulation of hippocampus and/or amygdala in both male and female animals (Velasco and Taleisnik, 1969;Gallo et al, 1971;Kawakami et al, 1973a,b).…”

Section: Sex Differences In Epilepsy and Comorbiditiesmentioning

confidence: 99%

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies

et al. 2020

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“…Earlier studies have shown sex differences in the response of rats to drugs affecting GABAergic transmission (35)(36)(37). These authors suggested that the sex difference observed was due to a difference among the sexes in GABA system activity.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Inhibitory Effect of Oestradiol on Functional GABA/5‐HT Relationship in the Rat Suprachiasmatic Area

François‐Bellan¹,

Héry²,

Faudon³

et al. 1989

J Neuroendocrinology

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The purpose of this study was to test the capacity of oestradiol to modulate the stimulating effect of a-aminobutyric acid (GABA) on serotonin (5-HT) metabolism, previously described in the suprachiasmatic area of the male rat. After an in vivo stimulation of GABA transmission by systemic administration of a GABA-transaminase inhibitor (amino-oxyacetic acid) or a GABA, agonist (RS-baclofen), the 5-HT metabolism was studied in the suprachiasmatic area of ovariectomized, and ovariectomized oestradiol-treated rats.Amino-oxyacetic acid or RS-baclofen treatment increased the endogenous content of 5-HT in the suprachiasmatic area of males and ovariectomized rats. These two treatments were without effect in ovariectomized oestradiol-treated rats. GABA transmission stimulation induced by amino-oxyacetic acid treatment failed to affect the release and synthesis of 5-HT in ovariectomized oestradiol-treated rats while it increased these two parameters of 5-HT metabolism in the suprachiasmatic area of male and ovariectomized rats. To investigate the main target of oestradiol effect, comparative studies of the serotoninergic and GABAergic metabolism in the suprachiasmatic area were performed in the three experimental groups. Under our experimental conditions the endogenous 5-HT metabolism was similar between ovariectornized and ovariectomized oestradiol-treated rats. Nevertheless, 5-HT metabolism was higher in the two female groups than in the male group. Neither GABA metabolism nor GABAergic response to GABA-related drug treatment differed between ovariectomized, and ovariectomized oestradiol-treated rats. However, the turnover of GABA was higher when compared to the two female groups. It is concluded that the lack of 5-HT responsiveness to GABA transmission stimulation in ovariectomized oestradiol-treated rats was not related to an effect of oestradiol on 5-HT metabolism or to an effect of the steroid on GABA turnover. Furthermore, our results suggest a sex difference in the activity of serotoninergic and GABAergic systems in the suprachiasmatic area.Recently, an anatomical relationship between GABAergic and szrotoninergic terminals in the suprachiasmatic nucleus (SCN) has been reported (1). Parallel to previous reports we have shown the existence of a metabolic interaction between these two neurotransmitters. The stimulation of y-aminobutyric acid (GABA) transmission leads to an increase in serotonin (5-HT) metabolism la GABA, receptor activation in the rat's suprachiasmatic area (SCA) (2, 3). The ability of oestradiol (E,) to influence neurotransmission has long been recognized. There are numerous (4-6) examples of mechanisms by which E, may act on neurotransmitter systems. These include the modulation of neurotransmitter metabolism and effects on neurotransmitter receptor concentrations. Data concerning the effects of the steroid on 5-HT and GABA metabolism in the hypothalamus are conflicting. While some authors report that E, administration to ovariectomized animals (OVX) results in no change in 5-HT content of...

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Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats

Cited by 6 publications

References 25 publications

Sexual Dimorphism in the Response of the GABAergic System to Estrogen Administration

Sexual Dimorphism in the Response of the GABAergic System to Estrogen Administration

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies

Analysis of the Inhibitory Effect of Oestradiol on Functional GABA/5‐HT Relationship in the Rat Suprachiasmatic Area

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