Differential effects of pure human alpha and gamma interferons on fibroblast cell growth and the cell cycle

Interferon-γ-mediated Inhibition of Cyclin A Gene Transcription Is Independent of Individual cis-Acting Elements in the Cyclin A Promoter

“…arrest of the cell cycle in the G 1 phase in fibroblasts (47,48) and mammary epithelial cells (18). In myeloid cells, growth arrest associated with IFN-␥ is linked to a decrease in expression of a principal G 1 cyclin, cyclin D1, even when the cytokine is added late in the G 1 phase (16).…”

Treatment of extra-abdominal desmoid tumors with interferon-alpha with or without tretinoin

“…Furthermore, in vitro investigations and animal experimental data suggest an antiproliferative effect of both IFN-␣ and retinoic acid on fibroblasts [6,7]. Therefore, the 13 patients included in our study were treated with IFN-␣ alone or with a combination of IFN-␣ and tretinoin.…”

“…Based on a case report of a positive effect of interferon-alpha (IFN-␣) on an abdominal desmoid tumor [5] and on in vitro data on the antiproliferative effects of retinoic acid and IFN-␣ on fibroblasts [6,7], it seemed appropriate to use IFN-␣ in patients with desmoid tumors after intralesional or marginal surgery, after recurrence, or in lesions of considerable extent. Thus, a retrospective analysis and literature review were undertaken to evaluate the possibility of improving the surgical treatment of desmoid tumors by using IFN-␣ ± tretinoin.…”

Direct growth suppressive activity of interferon-? and -? on human gastric cancer cells

“…The direct anti-tumor effects of IFN-␣ are associated with induction of cell cycle arrest [4,5] and apoptosis [6] or both [8], depending on the cell line. In addition, IFN-␣ enhances growth-inhibition activity induced by differentiation-inducing agents [28].…”

“…IFNs inhibit the growth of several types of carcinoma cells through the induction of cell cycle arrest only or concomitantly with the induction of apoptosis [4][5][6][7][8][9][10][11][12][13][14]. The growth inhibition effects are thought to be mediated through the induction of IFN-inducible gene products, such as IRF1, IRF2, p21, p53, and Fas, that link to the regulation of cell proliferation or apoptosis [14][15][16].…”