Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4‐chloro‐2‐[2‐(2‐chloro‐phenoxy)‐acetylamino]‐benzoic acid (CBA) versus classical 9‐phenanthrol

Abstract

Abbreviations: BTP2, pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide, alias YM-58483; Ca V , voltage-gated Ca 2+ (channel); CBA, 4-chloro-2-[2-(2chloro-phenoxy)-acetylamino]-benzoic acid; ddH 2 0, double distilled H 2 0; EFS, electrical field stimulation; FFA, flufenamic acid; IK, intermediate conductance calcium activated K + (channel); K Ca 1.1, voltage and calcium activated large conductance K + (channel), alias BK or MaxiK + ; K V , voltage-gated K + (channel); Na V , voltage-gated Na + (channel); UBSM, urinary bladder smooth muscle; TRPM4, transient receptor potential melastatin type-4.