Differential effects of smoking and COPD upon circulating myeloid derived suppressor cells

Abstract

Smoking modulates circulating MDSCs. Their regulation appears altered in patients with COPD.

The role of myeloid-derived suppressor cells in the relationship between chronic obstructive pulmonary disease and lung cancer

“…Our group and others have shown that MDSC are involved in the immunopathogenesis of COPD [12,48]. Our study provides evidence that expansion of circulating MDSC in COPD patients is associated with increased serum levels of ARG 1 and TCR ζ downregulation [12]. Other researchers reported similar findings: MDSC expansion was associated with increased levels of functional suppressor regulatory T cells (T-reg) and exhausted T effector cells (programmed death 1 [PD-1 + ]1) [13].…”

“…Recent studies highlight an emerging and complex role for MDSC in chronic inflammatory pulmonary diseases of different aetiologies, including lung cancer, asthma, cystic fibrosis and tuberculosis [46][47][48]. Our group and others have shown that MDSC are involved in the immunopathogenesis of COPD [12,48]. Our study provides evidence that expansion of circulating MDSC in COPD patients is associated with increased serum levels of ARG 1 and TCR ζ downregulation [12].…”

“…Our research group and others have described circulating MDSC upregulation associated with T-cell dysfunction in COPD patients [12,13]. Moreover, our group has recently shown that the pattern of expansion and activation of circulating MDSC associated with T-cell hyporesponsiveness is similar in COPD and lung cancer patients [14].…”

The emerging role of myeloid-derived suppressor cells in lung diseases

“…Smoking upregulated and activated circulating MDSCs in COPD patients, but not in smokers with normal lung function [118]. In COPD patients the MDSC activation was accompanied by down-regulation of the T-cell receptor ζ chain expression in T-cells [118].…”

“…Smoking upregulated and activated circulating MDSCs in COPD patients, but not in smokers with normal lung function [118]. In COPD patients the MDSC activation was accompanied by down-regulation of the T-cell receptor ζ chain expression in T-cells [118]. In addition, it has been shown that MDSCs were elevated in the bone marrow, spleens, and lungs after 4 months of cigarette smoke exposure, while this was paralleled by decreased pulmonary DCs [119].…”