Differential effects of specific opioid receptor agonists on rat pup isolation calls

Carden, Susan E.; Barr, Gordon A.; Hofer, Myron A.

doi:10.1016/0165-3806(91)90185-l

Cited by 113 publications

(76 citation statements)

References 27 publications

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“…Specifically in the rat neonate, opioids facilitate odor preference learning (Barr & Rossi, 1992;Kehoe & Blass, 1986a;Panksepp, Nelson, & Siviy, 1994;Randall, Kraemer, Dose, Carbary, & Bardo, 1992;Roth & Sullivan, 2001Shide & Blass, 1991), and nipple-milk conditioning (Petrov, Varlinskaya, Becker, & Smotherman, 1998, Petrov, Varlinskaya, & Smotherman, 2000Robinson, Arnold, Spear, & Smotherman, 1993;Robinson & Smotherman, 1997). Suggestive of their rewarding value in neonates, opioids are sufficient to alleviate separation distress (Carden, Barr, & Hofer, 1991;Goodwin, Molina, & Spear, 1994;Kehoe & Blass, 1986b;Panksepp, Herman, Conner, Bishop, & Scott, 1978). Additionally, Moles, Kieffer, and D'Amota (2004) have recently demonstrated that mice neonates lacking m-opioid receptors fail to show preferences toward maternal odor and do not show distress when separated from the mother, indicative that opioids play a prominent role in modulating the rewarding experience of mother-infant interactions.…”

Section: Discussionmentioning

confidence: 99%

Examining the role of endogenous opioids in learned odor–stroke associations in infant rats

Roth

Sullivan

2005

Developmental Psychobiology

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Maternal touch profoundly regulates infant neural and behavioral development, and supports learned odor associations necessary for infant attachment. Endogenous opioids are well characterized to mediate the calming and analgesic properties of maternal touch; yet their role in learned odor-touch associations is unknown. We administered naltrexone, an opioid receptor antagonist, before or immediately following classical conditioning with peppermint odor and tactile stimulation (stroking) in rat neonates. Results indicate odor-stroke conditioning produces odor preferences facilitated by endogenous opioids during acquisition and memory consolidation. These results provide additional evidence for the modulatory role of opioids in neonate learning and memory. Disturbances to this system may alter the impact of touch on infant development, particularly in the realm of learning necessary for attachment. ß 2005 Wiley Periodicals, Inc. Dev Psychobiol 48: 71-78, 2006.

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Section: Discussionmentioning

confidence: 99%

Examining the role of endogenous opioids in learned odor–stroke associations in infant rats

Roth

Sullivan

2005

Developmental Psychobiology

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“…Endogenous opioids are critical substrates for consummatory reward (Levine et al, 1985), which is associated with bringing the organism back to homeostasis related to primary drives, such as those governing sex, hunger, and thirst. Furthermore, ultrasonic vocalizations are also inhibited by opioid agonists in a variety of species (Herman and Panksepp, 1978;Kalin et al, 1988;Carden et al, 1991Carden et al, , 1994 with μ-opioid receptors the likely mediators of this effect. Supporting the specificity of these effects, opioid antagonists potentiate distress vocalizations Panksepp, 1978, 1981;Panksepp et al, 1980bPanksepp et al, , 1985Kalin et al, 1988), and milk creates the analgesic and behavioral effects associated with opiate administration (Smotherman and Robinson, 1987;Blass and Fitzgerald, 1988).…”

Section: Proximity Maintenance and Maintaining Securitymentioning

confidence: 99%

Toward a Radically Embodied Neuroscience of Attachment and Relationships?

2014

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Attachment theory (Bowlby, 1969(Bowlby, /1982 posits the existence of internal working models as a foundational feature of human bonds. Radical embodied approaches instead suggest that cognition requires no computation or representation, favoring a cognition situated in a body in an environmental context with affordances for action (Chemero, 2009;Barrett, 2011;Wilson and Golonka, 2013;Casasanto and Lupyan, 2015). We explore whether embodied approaches to social soothing, interpersonal warmth, separation distress, and support seeking could replace representational constructs such as internal working models with a view of relationship cognition anchored in the resources afforded to the individual by their brain, body, and environment in interaction. We review the neurobiological bases for social attachments and relationships and attempt to delineate how these systems overlap or don't with more basic physiological systems in ways that support or contradict a radical embodied explanation. We suggest that many effects might be the result of the fact that relationship cognition depends on and emerges out of the action of neural systems that regulate several clearly physically grounded systems. For example, the neuropeptide oxytocin appears to be central to attachment and pair-bond behavior (Carter and Keverne, 2002) and is implicated in social thermoregulation more broadly, being necessary for maintaining a warm body temperature (for a review, see IJzerman et al., 2015b). Finally, we discuss the most challenging issues around taking a radically embodied perspective on social relationships. We find the most crucial challenge in individual differences in support seeking and responses to social contact, which have long been thought to be a function of representational structures in the mind (e.g., Baldwin, 1995). Together we entertain the thought to explain such individual differences without mediating representations or computations, but in the end propose a hybrid model of radical embodiment and internal representations.

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“…As there are several sub-types of opioid receptors in the brain (morphine and naloxone working at the mu receptor), studies have attempted to determine which receptor subtypes are involved in rat pup isolation calling. Carden, et al [17] found that ligands that are agonists to mu, delta and kappa opioid receptors all effect crying rate in rat pups. However, while the mu and delta agonists suppressed crying, the kappa agonist actually increased crying.…”

Section: Neurochemical Control Of Cryingmentioning

confidence: 99%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

182

132

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Crying is a universal vocalization in human infants, as well as in the infants of other mammals. Little is known about the neural structures underlying cry production, or the circuitry that mediates a caregiver's response to cry sounds. In this review, the specific structures known or suspected to be involved in this circuit are identified, along with neurochemical systems and hormones for which evidence suggests a role in responding to infants and infant cries. In addition, evidence that crying elicits parental responses in different mammals is presented. An argument is made for including 'crying' as a functional category in the vocal repertoire of all mammalian infants (and the adults of some species). The prevailing neural model for crying production considers forebrain structures to be dispensable. However, evidence for the anterior cingulate gyrus in cry production, and this structure along with the amygdala and some other forebrain areas in responding to cries is presented.

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Differential effects of specific opioid receptor agonists on rat pup isolation calls

Cited by 113 publications

References 27 publications

Examining the role of endogenous opioids in learned odor–stroke associations in infant rats

Examining the role of endogenous opioids in learned odor–stroke associations in infant rats

Toward a Radically Embodied Neuroscience of Attachment and Relationships?

Neural circuits underlying crying and cry responding in mammals

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