Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

Beardsley, Patrick M.; Howard, James L.; Shelton, Keith L.; Carroll, F. Ivy

doi:10.1007/s00213-005-0167-4

Cited by 275 publications

(412 citation statements)

References 37 publications

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“…The findings of the present study are consistent with previous reports (Beardsley et al 2005;Carey et al 2007;Valdez et al 2007). Beardsley et al (2005) showed that intermittent and uncontrollable footshock was able to reinstate active lever responding on a lever previously associated with cocaine self-administration and that pre-treatment with the kappa antagonist JDTic attenuated footshock-induced cocaine-seeking behavior.…”

Section: Discussionsupporting

confidence: 94%

“…Consistent with this prediction, rodents given either an intermittent footshock or a forced swim stressor failed to reinstate drug-seeking behaviors after administration of kappa receptor antagonists (Beardsley et al 2005;Carey et al 2007). In this study, we extend these findings by determining the effects of the kappa antagonist norbinaltorphimine and disruption of the kappa system by gene deletion of either the kappa opioid receptor or the endogenous ligand dynorphin on forced-swim-stress-and foot-shockstress-induced reinstatement of cocaine-conditioned place preference.…”

Section: Introductionsupporting

confidence: 58%

“…Carey et al (2007) also demonstrated that the kappa receptor antagonist arodyn blocked forced-swim-stress-induced reinstatement of cocaine-seeking behavior using a conditioned place preference protocol. Beardsley et al (2005) and Carey et al (2007) also demonstrated that antagonism of the kappa receptor failed to attenuate cocaine-induced reinstatement.…”

Section: Discussionmentioning

confidence: 97%

“…Beardsley et al (2005) showed that intermittent and uncontrollable footshock was able to reinstate active lever responding on a lever previously associated with cocaine self-administration and that pre-treatment with the kappa antagonist JDTic attenuated footshock-induced cocaine-seeking behavior. Carey et al (2007) also demonstrated that the kappa receptor antagonist arodyn blocked forced-swim-stress-induced reinstatement of cocaine-seeking behavior using a conditioned place preference protocol.…”

Section: Discussionmentioning

confidence: 98%

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Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

2008

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Introduction-Prior activation of the kappa opioid system by repeated stress or agonist administration has been previously shown to potentiate the rewarding properties of subsequently administered cocaine. In the present study, intermittent and uncontrollable footshock, a single session of forced swim, or acute administration of the kappa agonist U50,488 (5 mg/kg) were found to reinstate place preference in mice previously conditioned with cocaine (15 mg/kg) and subsequently extinguished by repeated training sessions without drug.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

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Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

2008

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“…Finally, JDTic ((3R)-7-hydroxy-N-((1S)-1-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide) is a potent and selective kappa-opioid receptor antagonist [90] that has been reported to have antidepressantlike effects [91]. Such antidepressant activity could be mediated by blockade of monoamine transporters.…”

Section: Miscellaneous Drugsmentioning

confidence: 99%

Therapeutic Potential of Monoamine Transporter Substrates

Rothman¹,

Baumann²

2006

CTMC

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Monoamine transporter proteins are targets for many psychoactive compounds, including therapeutic and abused stimulant drugs. This paper reviews recent work from our laboratory investigating the interaction of stimulants with transporters in brain tissue. We illustrate how determining the precise mechanism of stimulant drug action (uptake inhibitor vs. substrate) can provide unique opportunities for medication discovery. An important lesson learned from this work is that drugs which display equipotent substrate activity at dopamine (DA) and serotonin (5-HT) transporters have minimal abuse liability and few stimulant side-effects, yet are able to suppress ongoing drug-seeking behavior. As a specific example, we describe the development of PAL-287 (α-methylnapthylethylamine), a dual DA/5-HT releasing agent that suppresses cocaine self-administration in rhesus monkeys, without the adverse effects associated with older phenylethylamine 5-HT releasers (e.g., fenfluramine) and DA releasers (e.g., amphetamine). Our findings demonstrate the feasibility of developing non-amphetamine releasing agents as potential treatments for substance abuse disorders and other psychiatric conditions.

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Prime‐, Stress‐, and Cue‐Induced Reinstatement of Extinguished Drug‐Reinforced Responding in Rats: Cocaine as the Prototypical Drug of Abuse

Beardsley

Shelton

2012

CP Neuroscience

Self Cite

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This unit describes the testing of rats in prime-, footshock- and cue-induced reinstatement procedures. Evaluating rats in these procedures enables the assessment of treatments on behavior thought to model drug relapse precipitated by re-contact with an abused drug (prime-induced), induced by stress (footshock-induced), or by stimuli previously associated with drug administration (cue-induced). For instance, levels of reinstatement under the effects of test compound administration could be compared to levels under vehicle administration to help identify potential treatments for drug relapse, or reinstatement levels of different rat strains could be compared to identify potential genetic determinants of perseverative drug-seeking behavior. Cocaine is used as a prototypical drug of abuse, and relapse to its use serves as the model in this unit, but other self-administered drugs could readily be substituted with little modification to the procedures.

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Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

Abstract: Depression and stress are two states during cocaine abstinence which users identify as precipitating relapse, and JDTic may have properties which attenuate both.

Cited by 275 publications

References 37 publications

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

Therapeutic Potential of Monoamine Transporter Substrates

Prime‐, Stress‐, and Cue‐Induced Reinstatement of Extinguished Drug‐Reinforced Responding in Rats: Cocaine as the Prototypical Drug of Abuse

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