Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system: An electrophysiological and intravital microscopy study in rats

Dolgorukova, Antonina; Isaeva, Julia; Verbitskaya, Elena; Lyubashina, O. A.; Giniatullin, Rashid; Sokolov, Alexey Y.

doi:10.1016/j.expneurol.2021.113634

Cited by 14 publications

(5 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Piezo1 enables cells to sense various “outside-in” and “inside-out” mechanical forces, including radial pressure, membrane tension, compression, shear stress, matrix stiffness, ultrasound, etc., and is considered to be the main mechanical sensor in bone homeostasis [ 51 ]. Dolgorukova et al [ 52 ] have shown that Piezo1 channels regulate physiological function by activating TRPV1. Piezo2 plays a key role in tactile sensation and is highly expressed in osteocytes.…”

Section: Discussionmentioning

confidence: 99%

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Wu,

Huang

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Wu,

Huang

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

“…In addition, use of pharmacological agents, such as Piezo1 agonists (Yoda1, Jedi1/2) and/or antagonists (Dooku1, Gadolinium, GsMTx4) would provide evidence for a potential use as therapeutic interventions. Recent interest has been given to the emerging role of Piezo1 in meningeal nociception leading to migraine headache, [ 114 , 115 ] with speculation into roles for modulating/mitigating VF mucosal injury. We conclude that Piezo1 mechanosensitive ion channels play a crucial role in VF regeneration and remodeling, likely through regulating epithelial self-renewal via effects on p63 transcription and YAP subcellular localization—altering cytokeratin differentiation (Fig.…”

Section: Discussionmentioning

confidence: 99%

Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation

Foote

Lungová

Thibeault

2022

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Mechanoreceptors are implicated as functional afferents within mucosa of the airways and the recent discovery of mechanosensitive channels Piezo1 and Piezo2 has proved essential for cells of various mechanically sensitive tissues. However, the role for Piezo1/2 in vocal fold (VF) mucosal epithelia, a cell that withstands excessive biomechanical insult, remains unknown. The purpose of this study was to test the hypothesis that Piezo1 is required for VF mucosal repair pathways of epithelial cell injury. Utilizing a sonic hedgehog (shh) Cre line for epithelial-specific ablation of Piezo1/2 mechanoreceptors, we investigated 6wk adult VF mucosa following naphthalene exposure for repair strategies at 1, 3, 7 and 14 days post-injury (dpi). PIEZO1 localized to differentiated apical epithelia and was paramount for epithelial remodeling events. Injury to wildtype epithelium was most appreciated at 3 dpi. Shhcre/+; Piezo1loxP/loxP, Piezo2 loxP/+ mutant epithelium exhibited severe cell/nuclear defects compared to injured controls. Conditional ablation of Piezo1 and/or Piezo2 to uninjured VF epithelium did not result in abnormal phenotypes across P0, P15 and 6wk postnatal stages compared to heterozygote and control tissue. Results demonstrate a role for Piezo1-expressing VF epithelia in regulating self-renewal via effects on p63 transcription and YAP subcellular translocation—altering cytokeratin differentiation.

show abstract

“…Indeed, in ex vivo hemiskull meningeal preparation, the specific Piezo1 agonist Yoda1 activated sustained nociceptive spiking activity in the trigeminal nerve fibers [ 94 ]. Further, in the other paper, Piezo1 role has been shown in vivo, resulting in activation of brainstem neurons after dural application of low doses of the specific Piezo1 agonist Yoda1, while the same agonist reduced neuronal activity at higher dose [ 96 ].…”

Section: Methodsmentioning

confidence: 99%

Mechanosensitive receptors in migraine: a systematic review

Della Pietra,

Gómez Dabó,

Mikulenka

et al. 2024

J Headache Pain

View full text Add to dashboard Cite

Background Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensitive receptors of different families, which specifically respond to various mechanical stimuli, have gathered increasing attention due to their potential role in migraine related nociception. Understanding these mechanisms is of principal importance for improved therapeutic strategies. This systematic review comprehensively examines the involvement of mechanosensitive mechanisms in migraine pain pathways. Methods A systematic search across the Cochrane Library, Scopus, Web of Science, and Medline was conducted on 8th August 2023 for the period from 2000 to 2023, according to PRISMA guidelines. The review was constructed following a meticulous evaluation by two authors who independently applied rigorous inclusion criteria and quality assessments to the selected studies, upon which all authors collectively wrote the review. Results We identified 36 relevant studies with our analysis. Additionally, 3 more studies were selected by literature search. The 39 papers included in this systematic review cover the role of the putative mechanosensitive Piezo and K2P, as well as ASICs, NMDA, and TRP family of channels in the migraine pain cascade. The outcome of the available knowledge, including mainly preclinical animal models of migraine and few clinical studies, underscores the intricate relationship between mechanosensitive receptors and migraine pain symptoms. The review presents the mechanisms of activation of mechanosensitive receptors that may be involved in the generation of nociceptive signals and migraine associated clinical symptoms. The gender differences of targeting these receptors as potential therapeutic interventions are also acknowledged as well as the challenges related to respective drug development. Conclusions Overall, this analysis identified key molecular players and uncovered significant gaps in our understanding of mechanotransduction in migraine. This review offers a foundation for filling these gaps and suggests novel therapeutic options for migraine treatments based on achievements in the emerging field of mechano-neurobiology.

show abstract

Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system: An electrophysiological and intravital microscopy study in rats

Cited by 14 publications

References 68 publications

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation

Mechanosensitive receptors in migraine: a systematic review

Contact Info

Product

Resources

About