2024
DOI: 10.26508/lsa.202302540
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Differential effects of translation inhibitors onPlasmodium bergheiliver stage parasites

James L McLellan,
Kirsten K Hanson

Abstract: Increasing numbers of antimalarial compounds are being identified that converge mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or mechanism. A deeper understanding of how their effectiveness as liver stage translation inhibitors relates to their chemoprotective potential could prove useful. Here, we probed that relationship using thePlasmodium berghei–HepG2 liver stage infection model. After determining translation inhibition EC50s for five compounds, we tested the… Show more

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Cited by 2 publications
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