Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability

Pierzynowska, Karolina; A, Rzeszótko; Blendowska, Aleksandra; Wieczerzak, Ewa; Rodziewicz‐Motowidło, Sylwia; Piotrowska, Ewa; Węgrzyn, Grzegorz

doi:10.18388/abp.2018_2596

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Phytochemical research on PES leaves has revealed the functions of 4 flavonoids and their working mechanisms [7]. Flavonoids are thought to be biologically active natural products present in a variety of fruits, vegetables, grains, and other dietary supplements [8][9][10]; flavonoids have attracted substantial attention because of their antioxidant abilities, chemopreventive properties, and radical scavenging activities, as well as cardiovascular protective, anti-inflammatory, and antiviral effects [11][12][13][14][15][16][17]. There is a growing interest in the analysis and identification of the flavonoid constituents of medicinal plants to identify the structure-activity relationship of flavonoids, as a small difference in the structure of a flavonoid can cause significant changes in its biological activities [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Characterization and identification of the major flavonoids in Phyllostachys edulis leaf extract by UPLC–QTOF–MS/MS

Shao

Ting

Wang

et al. 2020

Acta Chromatographica

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Phyllostachys edulis (PES), the most important bamboo species in China, is widely distributed in East Asia. Flavonoids, which are important bioactive natural compounds, often have similar structures, making their structural elucidation difficult. The aim of this study was to represent valuable, reliable mass spectral data for the identification of flavonoids in plant leaves. Ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC–Q-TOF-MS/MS) method was established for characterization and identification of the major flavonoids in PES leaf extract. A total of 13 flavonoids were simultaneously characterized, and their proposed characteristic product ions and fragmentation pathways were investigated. Thirteen compounds were separated on an Agilent Zorbax RRHD SB-C18 column (150 mm × 2.1 mm, 1.8 μm). On the basis of comparing with the 4 reference standards and the literature data, the other 9 flavonoids were identified by tandem mass spectrometry (MS/MS). Eight compounds (compounds 1, 4, 5, 8, 9, 10, 11, and 12) were found in PES leaves for the first time. An efficient UPLC–QTOF-MS/MS method was successfully applied for the structural identification of flavonoids in PES leaves. These results have practical applications for the rapid identification and structural characterization of these compounds in crude bioactive extracts or mixtures.

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Section: Introductionmentioning

confidence: 99%

Characterization and identification of the major flavonoids in Phyllostachys edulis leaf extract by UPLC–QTOF–MS/MS

Shao

Ting

Wang

et al. 2020

Acta Chromatographica

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“…Genistein is another flavonoid with a therapeutic potential in AD [ 43 ]. Like all flavonoids, genistein has antioxidant and anti-inflammatory properties and stimulates autophagy [ 44 ].…”

Section: Overview Of the Use Of Flavonoids In Neurodegenerative Disor...mentioning

confidence: 99%

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Szulc,

Wiśniewska,

Żabińska

et al. 2024

Foods

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Over the past decades, there has been a significant increase in the burden of neurological diseases, including neurodegenerative disorders, on a global scale. This is linked to a widespread demographic trend in which developed societies are aging, leading to an increased proportion of elderly individuals and, concurrently, an increase in the number of those afflicted, posing one of the main public health challenges for the coming decades. The complex pathomechanisms of neurodegenerative diseases and resulting varied symptoms, which differ depending on the disease, environment, and lifestyle of the patients, make searching for therapies for this group of disorders a formidable challenge. Currently, most neurodegenerative diseases are considered incurable. An important aspect in the fight against and prevention of neurodegenerative diseases may be broadly understood lifestyle choices, and more specifically, what we will focus on in this review, a diet. One proposal that may help in the fight against the spread of neurodegenerative diseases is a diet rich in flavonoids. Flavonoids are compounds widely found in products considered healthy, such as fruits, vegetables, and herbs. Many studies indicated not only the neuroprotective effects of these compounds but also their ability to reverse changes occurring during the progression of diseases such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis. Here, we present the main groups of flavonoids, discussing their characteristics and mechanisms of action. The most widely described mechanisms point to neuroprotective functions due to strong antioxidant and anti-inflammatory effects, accompanied with their ability to penetrate the blood-brain barrier, as well as the ability to inhibit the formation of protein aggregates. The latter feature, together with promoting removal of the aggregates is especially important in neurodegenerative diseases. We discuss a therapeutic potential of selected flavonoids in the fight against neurodegenerative diseases, based on in vitro studies, and their impact when included in the diet of animals (laboratory research) and humans (population studies). Thus, this review summarizes flavonoids’ actions and impacts on neurodegenerative diseases. Therapeutic use of these compounds in the future is potentially possible but depends on overcoming key challenges such as low bioavailability, determining the therapeutic dose, and defining what a flavonoid-rich diet is and determining its potential negative effects. This review also suggests further research directions to address these challenges.

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“…Isoflavones are a subclass of flavonoids and the most common phytoestrogens. 16 , 17 Biological activities of isoflavones present in dietary supplements have been widely studied, 18 , 19 , 20 for example, isoflavone impact on the health of postmenopausal women. 21 , 22 Isoflavones prevent bone resorption, 23 , 24 , 25 moreover they increase the efficacy and prevent the adverse effects of cancer chemotherapy and radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Identification of isoflavones in the extract of supplements for menopause symptoms by direct infusion electrospray ionization tandem mass spectrometry

Beszterda

Frański

2020

Analytical Science Advances

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In recent years high consumption of dietary supplements has been observed. However, the consumption of dietary supplements may lead to the unexpected side effects that can be related to the number of adulterated supplements quite often marketed. It has prompted the search for a fast and reliable method of identification of main active compounds in the supplements. In this study, the isoflavones present in the methanol extracts of dietary supplements for menopause symptoms were identified by using direct infusion electrospray ionization tandem mass spectrometry. The product ion spectra of [M-H] − ions derived from the extracts matched very well those obtained for standard compounds. Daidzein, genistein, and glycitein were identified in the soybased supplements, while daidzein, formononetin, and biochanin A were identified in the red clover-based ones. The respective [M+Na] + ions were also detected; however, their product ion spectra did not allow isoflavone identification. It can be concluded that the main isoflavones present in the extracts of dietary supplements can be successfully and quickly identified by using the direct infusion electrospray ionization in negative ion mode, followed by the tandem mass spectrometry experiment.

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Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability

Cited by 4 publications

References 33 publications

Characterization and identification of the major flavonoids in Phyllostachys edulis leaf extract by UPLC–QTOF–MS/MS

Characterization and identification of the major flavonoids in Phyllostachys edulis leaf extract by UPLC–QTOF–MS/MS

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Identification of isoflavones in the extract of supplements for menopause symptoms by direct infusion electrospray ionization tandem mass spectrometry

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