Differential effects of β-adrenergic receptor blockade in basolateral amygdala or insular cortex on incidental and associative taste learning

Miranda, Marı́a Isabel; Rodríguez-García, Gabriela; Reyes-López, J.; Ferry, Barbara

doi:10.1016/j.nlm.2008.01.004

Cited by 27 publications

(19 citation statements)

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“…Our results clearly demonstrate that the BLA is involved in both associative and incidental odor learning, and this further contributes to the idea that neuronal activity in the BLA is required for odor encoding (Schoenbaum et al 1999(Schoenbaum et al , 2000Rosenkranz and Grace 2002). Moreover, our results add to a growing body of evidence indicating that BLA activity is not only required for associative/aversive learning but also for incidental learning, such as taste habituation (Miranda et al 2008), object recognition (Maroun and Akirav 2008;Roozendaal et al 2008), or pre-exposure to a neutral stimulus in an LI paradigm (Schauz and Koch 2000;Coutureau et al 2001;Miranda et al 2003). In our experiments, the odor was novel when the BLA was inactivated.…”

Section: The Bla Is Necessary For Novel Odor Encodingsupporting

confidence: 80%

“…Interestingly, even if previous studies indicate that the BLA is also required for CTA (Gallo et al 1992;Yamamoto et al 1995;Morris et al 1999;Yasoshima et al 2000), these cellular mechanisms seem not to be required for CTA. CTA acquisition was not affected by pre-CS blockade of b-adrenergic receptor in BLA (Miranda et al 2008), and the blockade of protein synthesis within the BLA did not impair CTA memory consolidation (Bahar et al 2003). The reason why the BLA seems to play a more critical role in COA than CTA remains to be clearly established, but it could be related to the differential involvement of the insular cortex in this conditioning.…”

Section: The Bla Is Necessary For Novel Odor Encodingmentioning

confidence: 95%

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The basolateral amygdala is necessary for the encoding and the expression of odor memory

Sevelinges

Desgranges²,

Ferreira³

2009

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Conditioned odor avoidance (COA) results from the association between a novel odor and a delayed visceral illness. The present experiments investigated the role of the basolateral amygdala (BLA) in acquisition and retrieval of COA memory. To address this, we used the GABA A agonist muscimol to temporarily inactivate the BLA during COA acquisition or expression. BLA inactivation before odor-malaise pairing greatly impaired COA tested 3 d later. In contrast, muscimol microinfusion between odor and malaise spared retention. Moreover, inactivation of the BLA before pre-exposure to the odor prevented latent inhibition of COA. This suggests that neural activity in the BLA is essential for the formation of odor representation. BLA inactivation before the retrieval test also blocked COA memory expression when performed either 3 d (recent memory) or 28 d (remote memory) after acquisition. This effect was transitory as muscimol-treated animals were not different from controls during the subsequent extinction tests. Moreover, muscimol infusion in the BLA neither affected olfactory perception nor avoidance behavior, and it did not induce a statedependent learning. Altogether, these findings suggest that neural activity in the BLA is required for the encoding and the retrieval of odor memory. Moreover, the BLA seems to play a permanent role in the expression of COA.Considerable evidence indicates that the amygdala, and more particularly, the basolateral nucleus of the amygdala (BLA), is necessary for aversive and emotional memories in rats and humans (for reviews, see McGaugh 2004;Phelps and LeDoux 2005). Numerous studies suggest that the BLA is involved in the formation of affective memory, but whether the amygdala stores such memory is controversial. Results of studies using fear conditioning support the view that essential aspects of learning take place in the BLA, which subserves long-term storage of fear memory (for review, see Phelps and LeDoux 2005). In particular, lesion studies showed that the BLA has a permanent role in the expression of learned fear (Maren et al. 1996;Gale et al. 2004). On the other hand, it has been suggested for inhibitory avoidance that the BLA is not the site of memory storage, but rather a region that is only temporarily required after training (for review, see McGaugh 2004). Consistent with this idea, the BLA is important for recent (1 d) but not for remote (>10 d) memory retrieval of inhibitory avoidance (Liang et al. 1982(Liang et al. , 1996Izquierdo et al. 1997).The importance of BLA has also been investigated in conditioned taste avoidance (CTA) and conditioned odor avoidance (COA), in which animals learn to avoid a taste or an odor, respectively (the conditioned stimulus, CS), previously paired with a visceral malaise (the unconditioned stimulus, US) (for reviews, see Garcia et al. 1985;Bures 1998;Batsell and Blankenship 2002). Taste was long considered the critical CS for food avoidance in comparison to odor (Palmerino et al. 1980;Garcia et al. 1985). However, it has been demonstrated ...

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Section: The Bla Is Necessary For Novel Odor Encodingsupporting

confidence: 80%

Section: The Bla Is Necessary For Novel Odor Encodingmentioning

confidence: 95%

The basolateral amygdala is necessary for the encoding and the expression of odor memory

Sevelinges

Desgranges²,

Ferreira³

2009

Learn. Mem.

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“…the animals do not increases the intake of the novel solution in the following trials; Miranda et al, 2008). This study shows that noradrenergic activity is required in acquisition of a novel taste, but didn't indicates how the administration of the drug is involved in the consolidation of the information.…”

Section: Introductionmentioning

confidence: 75%

Corticosterone and propranolol's role on taste recognition memory

Ruetti

Justel

Mustaca

et al. 2014

Pharmacology Biochemistry and Behavior

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“…However, a substantial component of our memories are related to incidental stimuli, that is, stimuli that have no overt emotional relation. Recent data have implicated the insular cortex (IC) in the formation of such "incidental" memories (BermudezRattoni 2004;Miranda and Bermudez-Rattoni 2007;Miranda et al 2008). The IC has substantial connections with the limbic system and the "reward circuit," and receives information from all sensory modalities Mufson and Mesulam 1982).…”

mentioning

confidence: 99%

“…Using an automated syringe pump (Sage Instruments), 0.5 mL of solution was infused over 60 sec, and the injection needle was kept in place for an additional 60 sec. The propranolol dose (1 mg/0.5 mL) was selected on the basis of previous findings (Miranda et al 2008).…”

mentioning

confidence: 99%

β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation

Miranda¹,

Sabath²,

Núñez-Jaramillo³

et al. 2011

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The goal of this research was to determine the effects of b-adrenergic antagonism in the IC before or after inhibitory avoidance (IA) training or context pre-exposure in a latent inhibition protocol. Pretraining intra-IC infusion of the b-adrenergic antagonist propranolol disrupted subsequent IA retention and impaired latent inhibition of IA, but had no effect on formation of memory for an inert context (termed incidental memory). These results indicate that IC b-adrenergic receptors are necessary for memory acquisition of an aversive, but not an inconsequential, context. Nevertheless, subsequent association of a familiar and hitherto inconsequential context with an unconditioned stimulus (US) does require activation of these receptors during its initial acquisition.Substantial evidence indicates that long-term memories related to emotional experiences are particularly robust (Buchanan 2007). However, a substantial component of our memories are related to incidental stimuli, that is, stimuli that have no overt emotional relation. Recent data have implicated the insular cortex (IC) in the formation of such "incidental" memories (BermudezRattoni 2004;Miranda and Bermudez-Rattoni 2007;Miranda et al. 2008). The IC has substantial connections with the limbic system and the "reward circuit," and receives information from all sensory modalities Mufson and Mesulam 1982). Functionally, the IC has been demonstrated to play a critical role in memory performance in a variety of memory tasks that use an aversive unconditioned stimulus (US), including taste recognition memory (Bermudez-Rattoni 2004), Morris spatial water maze Gutierrez et al. 1999), and the inhibitory-avoidance (IA) task , as well as memory performance in a task with no overtly aversive stimuli, namely, object recognition (Bermudez-Rattoni et al. 2005).Though the IC has been shown to be necessary for spatial and avoidance memory formation (Bermudez-Rattoni and McGaugh 1991) and the b-adrenergic system has been shown to play a critical role in IA consolidation (Barros et al. 2001;Lalumiere et al. 2004;McGaugh 2004), the functions of b-adrenergic activity in the IC during IA acquisition, consolidation, and retrieval are unknown. Hence, the present study was designed to examine the involvement of b-adrenergic receptors in the IC during acquisition and memory consolidation of the IA task. We further investigated whether b-adrenergic receptors in the IC might be differentially involved in mediating aversive and incidental contextual memory formation, as well as their role in a latent inhibition variant of the IA task. Specifically, the latent inhibition IA paradigm involves pre-exposing animals to the IA dark compartment in the absence of a footshock and then assessing their latency to enter that same dark compartment the following day, at which time a footshock is then administered. Lubow (1989) showed that this kind of pre-exposure reduces the probability of the apparatus context being associated with a footshock applied when the animal is placed in that context...

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Differential effects of β-adrenergic receptor blockade in basolateral amygdala or insular cortex on incidental and associative taste learning

Cited by 27 publications

References 28 publications

The basolateral amygdala is necessary for the encoding and the expression of odor memory

The basolateral amygdala is necessary for the encoding and the expression of odor memory

Corticosterone and propranolol's role on taste recognition memory

β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation

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