Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse

Goepel, Christian

doi:10.1016/j.acthis.2007.10.014

Cited by 60 publications

(35 citation statements)

References 20 publications

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“…Even though the techniques used to obtain the data vary and thus provide inconclusive data, there is circumstantial evidence that a deficient synthesis and degradation of elastic fibres may be associated with POP [42, 53, [55][56][57].…”

Section: Cross-linking Of Collagen In Popmentioning

confidence: 99%

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008

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Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level. The objective of this review is to test the hypothesis against recent literature. The method used was a review of literature. The association between POP and connective tissue metabolism is well established. However, the causality of this association is unclear. The characteristics of the pelvic floor connective tissue of POP patients relate to tissue repair. To resolve the question of cause and effect, the role of fibroblasts in producing the extracellular matrix should be clarified. With these data, the use of autologous or allogenic stem cells in the treatment of POP may come in sight. Recent literature supports the hypothesis of Jackson but does not resolve long-standing questions on the aetiology of POP.

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Section: Cross-linking Of Collagen In Popmentioning

confidence: 99%

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008

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“…Additionally, the vascular network around the urethra are known to contribute to female continence (6;7). connective tissue remodelling (10)(11)(12), changes in smooth muscle fibres (4;5), changes in the vascular network (6;7) and anatomical modifications due to pelvic floor surgery (13;14).…”

Section: The Female Pelvic Floormentioning

confidence: 99%

Long-term follow-up of the retropubic tension-free vaginal tape procedure

et al. 2013

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“…Dysfunction in neonatal formation of elastic fibers abrogates many of the changes in mechanical response that take place during the maturation. artery mechanics; extracellular matrix; elastin; arterial stiffening; fbln5 LOSS OF FUNCTIONAL ELASTIC fibers is associated with various vascular diseases, including abdominal aortic aneurysms (5, 46), peripheral arterial disease (42, 43), aortic dissection (30, 49), as well as pathologies in other organ systems (13,20). Fibulin-5 (fbln5) is an extracellular matrix protein that binds to integrins and localizes tropoelastin to microfibrils (39, 62).…”

mentioning

confidence: 99%

Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation

Wan

Gleason

2013

American Journal of Physiology-Heart and Circulatory Physiology

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Wan W, Gleason RL, Jr. Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation. Am J Physiol Heart Circ Physiol 304: H674 -H686, 2013. First published December 15, 2012 doi:10.1152/ajpheart.00459.2012.-Elastin fragmentation is a common characteristic of vascular diseases, such as abdominal aortic aneurysms, peripheral arterial disease, and aortic dissection. Examining growth and remodeling in the presence of dysfunctional elastic fibers provides insight into the adaptive or maladaptive changes that tissues undergo in compensating for structural deficiencies. This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries. The microstructural content and organization and the biaxial mechanical behavior of common carotid arteries were measured, and parameter estimation performed from KO and WT mice aged 3, 4, 8, and 13 wk. Gross measurements and biaxial tests revealed significant differences in pressure-diameter behavior, in vivo axial stretch, opening angle, compliance, and wall stresses during maturation of wild-type arteries, but little change in these values in KO mice. Multiphoton microscopy used to image collagen fibers across the vessel wall in pressurized and stretched arteries suggests that there is little variation in fiber angles between different ages. Parameter estimation revealed significant differences in material parameters between genotypes and age groups. This study suggests that neonatal formation and cross-linking of functional elastic fibers, followed by increases in artery size due to growth with little remodeling of the elastic fibers, endow arteries with large distensibility and contribute to the evolution of mechanical behavior of arteries during maturation. Dysfunction in neonatal formation of elastic fibers abrogates many of the changes in mechanical response that take place during the maturation. artery mechanics; extracellular matrix; elastin; arterial stiffening; fbln5 LOSS OF FUNCTIONAL ELASTIC fibers is associated with various vascular diseases, including abdominal aortic aneurysms (5, 46), peripheral arterial disease (42, 43), aortic dissection (30, 49), as well as pathologies in other organ systems (13,20). Fibulin-5 (fbln5) is an extracellular matrix protein that binds to integrins and localizes tropoelastin to microfibrils (39, 62). In humans, altered expression of fbln5 is correlated with a variety of diseases, such as thoracic aortic dissection (59), age-related macular degeneration (52), as well as various cancers (26,36,63). Fbln5 knockout (KO) mice exhibit loose skin, pelvic organ prolapse, and tortuous arteries with disrupted elastic lamellae (39,62). Previous studies have shown that arteries from adult fbln5 KO mice have altered biomechanical and microstructural properties, including disrupted and dysfunctional elastic lamellae (58); however, evolution of biomechanical an...

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Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse

Cited by 60 publications

References 20 publications

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

Long-term follow-up of the retropubic tension-free vaginal tape procedure

Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation

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