Differential epithelial cell response upon stimulation with the<i>Aggregatibacter actinomycetemcomitans</i>strains VT 1169, VT 1560 DAM<sup>-</sup>and ATCC 4318

Eberhard, Jörg; Banasch, Tobias; Jepsen, Søren; Dommisch, Henrik

doi:10.4161/epi.5.8.13106

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Interestingly, in gingival epithelial cells and gingival fibroblasts, the expression of human beta‐defensin‐2 and human beta‐defensin‐3 [also macrophage inflammatory protein‐2 alpha/chemokine (C‐C motif) ligand 20] genes was further up‐regulated when cells were exposed S. gordonii before stimulation with P. gingivalis . Even epigenetic variations in the bacterial DNA may influence the capacity of bacteria to stimulate the expression of antimicrobial peptides in gingival epithelial cells .…”

Section: Beta‐defensinsmentioning

confidence: 99%

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Dommisch¹,

Jepsen²

2015

Periodontology 2000

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Defensins are antimicrobial peptides that exhibit direct microbicidal activity as well as mediator-like functions by, for example, activating immature dendritic cells. This review focuses on defensins and other antimicrobial peptides that are present in periodontal tissues. Their antimicrobial capacity against periodontal microorganisms, their regulation and their expression profiles during periodontal diseases is discussed. As antimicrobial peptides may possess great potential for new diagnostic, preventive and therapeutic strategies, a better understanding of how antimicrobial peptides are regulated as part of the innate host immune response is crucial.

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Section: Beta‐defensinsmentioning

confidence: 99%

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Dommisch¹,

Jepsen²

2015

Periodontology 2000

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“…This attenuated phenotype was suggested to be due to its lacking bacterial DNAadenine-methyltransferase activity. Furthermore, the same study demonstrated that the observed effect in the innate immune response was perhaps associated with the heterogeneity of the studied human epithelial cells since the cells derived from different donors responded in a different manner (Eberhard et al 2010). These findings emphasize the potential significance of epigenetic modifications in the host microbial pathogenesis.…”

Section: Epigenetic Status In Infection-driven Inflammationmentioning

confidence: 73%

Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling

Morandini¹,

Santos²,

Yılmaz³

2016

Pathogens and Disease

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Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of host defenses that can lead to a more prominent immune response and shape the course of inflammation in the host. Thus, the epigenetics can both drive the production of specific inflammatory mediators and control the magnitude of the host response. The epigenetic actions that are predominantly shown to modulate the host defense against microbial pathogens are DNA methylation, histone modification and the activity of non-coding RNAs. There is also growing evidence that opportunistic chronic pathogens, such as Porphyromonas gingivalis, as a microbial host subversion strategy, can epigenetically interfere with the host DNA machinery for successful colonization. Similarly, the novel involvement of small molecule 'danger signals', which are released by stressed or infected cells, at the center of host-pathogen interplay and epigenetics is developing. In this review, we systematically examine the latest knowledge within the field of epigenetics in the context of host-derived danger molecule and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation.

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Pro-inflammatory cytokine responses in human gingival epithelial cells after stimulation with cell wall extract of Aggregatibacter actinomycetemcomitans subtypes

et al. 2017

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Differential epithelial cell response upon stimulation with theAggregatibacter actinomycetemcomitansstrains VT 1169, VT 1560 DAM^-and ATCC 4318

Cited by 3 publications

References 27 publications

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling

Pro-inflammatory cytokine responses in human gingival epithelial cells after stimulation with cell wall extract of Aggregatibacter actinomycetemcomitans subtypes

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Differential epithelial cell response upon stimulation with theAggregatibacter actinomycetemcomitansstrains VT 1169, VT 1560 DAM-and ATCC 4318

Cited by 3 publications

References 27 publications

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Diverse functions of defensins and other antimicrobial peptides in periodontal tissues

Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling

Pro-inflammatory cytokine responses in human gingival epithelial cells after stimulation with cell wall extract of Aggregatibacter actinomycetemcomitans subtypes

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Resources

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Differential epithelial cell response upon stimulation with theAggregatibacter actinomycetemcomitansstrains VT 1169, VT 1560 DAM^-and ATCC 4318