The article is devoted to the noncommutative integration of a diffusion partial differential equation (PDE). Its generalizations are also studied. This is motivated by the fact that many existing approaches for solutions of PDEs are based on evolutionary operators obtained as solutions of the corresponding stochastic PDEs. However, this is restricted to PDEs of an order not higher than 2 over the real or complex field. This article is aimed at extending such approaches to PDEs of an order higher than 2. For this purpose, measures and random functions having values in modules over complexified Cayley–Dickson algebras are investigated. Noncommutative integrals of hypercomplex random functions are investigated. By using them, the noncommutative integration of the generalized diffusion PDE is scrutinized. Possibilities are indicated for a subsequent solution of higher-order PDEs using their decompositions and noncommutative integration.