Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin

Bessis, Didier; Molès, Jeàn-Pierre; Basset-Séguin, Nicole; Tesniere, Anne; Arpin, Christophe; Guilhou, Jean‐Jacques

doi:10.1111/j.1365-2133.2004.06116.x

Cited by 38 publications

(37 citation statements)

References 37 publications

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“…The accumulation of mutations has led to a loss of infectivity of HERVs, and in general they are largely noninfectious retroviral remnants. However, open reading frames (ORFs) have been observed for ERV3, 4 HERV-E 4-1, 5 HERV-K, 6 HERV-W, 7 HERV-FRD, 8 HERV-H 9 and others 10 ; 3 of them are functional, namely HERV-K108, 6 HERV-W 7 and HERV-FRD. 8 The ERV3 retrovirus consists of a single-copy, full-length provirus that has a long ORF in the env region, 11,12 functional LTRs and a nondefective env glycoprotein gene.…”

mentioning

confidence: 99%

Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer

Wang-Johanning

Liu

Rycaj

et al. 2006

Intl Journal of Cancer

189

153

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Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We report here the expression of multiple HERV genes and proteins in ovarian cell lines and tissues. Expression of HERV-K env mRNA was greater in ovarian epithelial tumors than in normal ovarian tissues (N 5 254). The expression of this protein on the surface and in the cytoplasm of ovarian cancer cells was confirmed using anti-HERV-K specific antibody by flow cytometric analysis. The frequency of expression of HERV-K env protein in multitissue microarrays (N 5 641) was determined by immunohistochemistry and a significant correlation with tumor histotype was found. A significantly increased expression of HERV-K was observed in tumors with low malignant potential and low grade, relative to expression in normal ovarian tissues. The increase in expression of HERV-K env protein took place in a stepwise fashion in serous papillary adenocarcinoma. Interestingly, we found that other classes of HERV env mRNAs, including ERV3 and HERV-E, are expressed in the same ovarian cancer tissues that expressed HERV-K. Furthermore, anti-HERV antibodies including anti-ERV3 (30%), anti-HERV-E (40%) and anti-HERV-K (55%) were detected in patients with ovarian cancer, but not in normal female controls. HERV env proteins are frequently transcribed and translated in ovarian epithelial tumors, and multiple HERV families are detectable in ovarian cancer. HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. ' 2006 Wiley-Liss, Inc.

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mentioning

confidence: 99%

Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer

Wang-Johanning

Liu

Rycaj

et al. 2006

Intl Journal of Cancer

189

153

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“…A putative retroviral antigen designated pso-p27 was purified from these particles (231), and antibodies to pso-p27 were detected in patients (232). More recently, HERV-E RNA and Env proteins were found in psoriatic lesions (43,336), and antibodies that were reactive with MLV Gag and Env in patient sera have been described (335). Interestingly, HERV-E expression is down-regulated by UV irradiation, which also clears psoriatic lesions (43,214).…”

Section: Human Rna "Rumor" Viruses: Proving Causationmentioning

confidence: 99%

“…More recently, HERV-E RNA and Env proteins were found in psoriatic lesions (43,336), and antibodies that were reactive with MLV Gag and Env in patient sera have been described (335). Interestingly, HERV-E expression is down-regulated by UV irradiation, which also clears psoriatic lesions (43,214). While those reports provide intriguing evidence of retroviral activity in psoriasis, it is difficult to draw together the various strands, and none of the studies has related retrovirus expression to immunopathology.…”

Section: Human Rna "Rumor" Viruses: Proving Causationmentioning

confidence: 99%

Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease

Voisset

Weiss

Griffiths

2008

Microbiol Mol Biol Rev

145

156

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SUMMARY Retroviruses are an important group of pathogens that cause a variety of diseases in humans and animals. Four human retroviruses are currently known, including human immunodeficiency virus type 1, which causes AIDS, and human T-lymphotropic virus type 1, which causes cancer and inflammatory disease. For many years, there have been sporadic reports of additional human retroviral infections, particularly in cancer and other chronic diseases. Unfortunately, many of these putative viruses remain unproven and controversial, and some retrovirologists have dismissed them as merely “human rumor viruses.” Work in this field was last reviewed in depth in 1984, and since then, the molecular techniques available for identifying and characterizing retroviruses have improved enormously in sensitivity. The advent of PCR in particular has dramatically enhanced our ability to detect novel viral sequences in human tissues. However, DNA amplification techniques have also increased the potential for false-positive detection due to contamination. In addition, the presence of many families of human endogenous retroviruses (HERVs) within our DNA can obstruct attempts to identify and validate novel human retroviruses. Here, we aim to bring together the data on “novel” retroviral infections in humans by critically examining the evidence for those putative viruses that have been linked with disease and the likelihood that they represent genuine human infections. We provide a background to the field and a discussion of potential confounding factors along with some technical guidelines. In addition, some of the difficulties associated with obtaining formal proof of causation for common or ubiquitous agents such as HERVs are discussed.

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“…Later on, at least 4 discrete proteins were partially characterized from these virus-like particles [47], and immunological investigations indicated a reactivity of psoriatic sera against the major internal protein, p27 [48]. More recently, our group demonstrated the expression in lesional skin of the envelope of HERV-E [37] and an increased reverse transcriptase activity [49]. Additionally, a high prevalence of IgG type response against murine leukemia virus proteins was observed in psoriatic sera [50].…”

Section: Search For Human Endogenous Retrovirusesmentioning

confidence: 99%

“…All of them are transmitted as mendelian genes but some could be mobile through retrotransposition or direct DNA transposition [34, 35]. As a rule, they persist as silent copies often truncated or point mutated, but a few can be transcribed and even give rise to functional proteins [[36], [37], unpubl. results].…”

Section: A New Proposal For Reconciling Genetic Studiesmentioning

confidence: 99%

New Hypotheses in the Genetics of Psoriasis and Other ‘Complex’ Diseases

Guilhou¹,

Molès²

2008

Dermatology

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Psoriasis is a complex genetic disorder in which the disease, according to the current concept, is caused by the interplay of many different genes. However, recent genetic studies indicate that the location of these genes varies considerably among populations and families, raising the question of how the same phenotype can be induced by such variable genetic linkages. To circumvent these discrepancies we propose that psoriasis could be induced by the same repetitive DNA sequence, an endogenous retroviral element present at different locations in the genome. The occurrence of the disease could be linked to an abnormal activation of one or more endogenous retroviral element copies due to their location and/or to modification of their sequence. This unifying concept would simplify our understanding of genetically complex diseases.

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Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin

Abstract: These data suggest for the first time that HERV-E env is expressed in normal and pathological human skin. Further studies are now required to elucidate the role of such viral proteins in the pathogenesis of psoriasis.

Cited by 38 publications

References 37 publications

Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer

Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer

Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease

New Hypotheses in the Genetics of Psoriasis and Other ‘Complex’ Diseases

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