Differential expression of adipocyte and myotube extracellular vesicle miRNA cargo in chronic binge alcohol-administered SIV-infected male macaques

Bourgeois, Brianna; Levitt, Danielle E.; Molina, Patricia; Simon, Liz

doi:10.1016/j.alcohol.2022.11.001

Cited by 4 publications

(1 citation statement)

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“…Results showed significant alterations in expression of myomiRs in extracellular vesicles derived from myotubes formed from myoblasts isolated from CBA animals; however, no significant differences existed in extracellular vesicle size or concentration. 129 CBA also dysregulated expression of genes implicated in mitochondrial homeostasis (e.g., peroxisome proliferator-activated receptor gamma, coactivator 1 beta [PGC-1b]; PPAR-alpha; estrogen-related receptor alpha; and superoxide dismutase) in SKM of ART-naïve SIV-infected male macaques at end-stage disease. 130 In animals that were treated with ART and with controlled infection, CBA decreased succinate dehydrogenase activity (complex II of the electron transport chain) in type 1 and type 2 fibers, as well as myoblast maximal oxygen consumption rate.…”

Section: Results Of the Reviewed Studiesmentioning

confidence: 99%

Alcohol and Skeletal Muscle in Health and Disease

Simon

2023

ARCR

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PURPOSE Alcohol-related myopathy is one of the earliest alcohol-associated pathological tissue changes that is progressively exacerbated by cumulative long-term alcohol misuse. Acute and chronic alcohol use leads to changes in skeletal muscle mass and function. As discussed in this evidence-based review, alcohol-mediated mechanisms are multifactorial with effects on anabolic and catabolic signaling, mitochondrial bioenergetics, extracellular matrix remodeling, and epigenomic alterations. However, systematic studies are limited, especially regarding the acute effects of alcohol on skeletal muscle. SEARCH METHODS This review focuses on peer-reviewed manuscripts published between January 2012 and November 2022 using the search terms “alcohol” or “ethanol” and “skeletal muscle” in MEDLINE, PubMed, and Web of Science using EndNote reference management software. SEARCH RESULTS Eligible manuscripts included full-length research papers that discussed acute and chronic effects of alcohol on skeletal muscle mass and function in both clinical and preclinical studies. The review also includes alcohol-mediated skeletal muscle effects in the context of comorbidities. The three databases together yielded 708 manuscripts. Of these, the authors excluded from this review 548 papers that did not have “alcohol” or “muscle” in the title and 64 papers that were duplicates or did not discuss skeletal muscle. Thus, of all the manuscripts considered for this review, 96 are included and 612 are excluded. Additionally, relevant papers published earlier than 2012 are included to provide context to the review. DISCUSSION AND CONCLUSIONS Both acute and chronic alcohol use decrease protein synthesis and increase protein degradation. Alcohol also impairs mitochondrial function and extracellular matrix remodeling. However, there is a gap in the literature on the known alcohol-mediated mechanisms, including senescence, role of immune activation, and interorgan communication, on the development of alcohol-related myopathy. With increased life expectancy, changing alcohol use patterns, and increasing frequency of alcohol use among females, current observational studies are needed on the prevalence of alcohol-related myopathy. Additionally, the compounding effects of acute and chronic alcohol use on skeletal muscle with aging or exercise, in response to injury or disuse, and in the context of comorbidities including diabetes and human immunodeficiency virus (HIV), call for further investigation. Though evidence suggests that abstinence or reducing alcohol use can improve muscle mass and function, they are not restored to normal levels. Hence, understanding the pathophysiological mechanisms can help in the design of therapeutic strategies to improve skeletal muscle health.

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Section: Results Of the Reviewed Studiesmentioning

confidence: 99%