Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus

González-Curiel, Irma; Castañeda-Delgado, Julio Enrique; López-López, Nallely; Araujo, Zaida; Hernández-Pando, Rogelio; Gándara-Jasso, Benjamín; Macías-Segura, N.; Enciso-Moreno, Antonio; Rivas-Santiago, Bruno

doi:10.1016/j.humimm.2011.03.027

Cited by 68 publications

(42 citation statements)

References 32 publications

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“…When primary cell cultures form ulcer were infected with different S. aureus multiplicities of infection (MOI), all DFU biopsies showed down expression of cathelicidin in comparison with primary cell cultures from healthy donors. These results correlates with previous studies by our group that demonstrated in peripheral blood cells from diabetic patients no detectable expression of cathelicidin [28]. This absence of cathelicidin may contribute directly with the delay or incapacity of DFU for wound healing.…”

Section: Discussionsupporting

confidence: 92%

“…This up-regulation could be produced from tissue repair and inflammatory milieu in ulcers, since bacterial cultures from ulcer swabs were negative. Conversely, previous results by our group showed that defensins are in lower concentrations in PBMC from diabetic patients [28]. These apparent contradictory results suggest that despite chronic ulcers from diabetic patients showed b-defensins up-regulation, the production of these antimicrobial peptides might be insufficient to mount a proper antimicrobial control and wound healing.…”

Section: Discussioncontrasting

confidence: 65%

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Expression of antimicrobial peptides in diabetic foot ulcer

Rivas-Santiago¹,

Trujillo²,

Montoya³

et al. 2012

Journal of Dermatological Science

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 65%

Expression of antimicrobial peptides in diabetic foot ulcer

Rivas-Santiago¹,

Trujillo²,

Montoya³

et al. 2012

Journal of Dermatological Science

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“…Our observations are consistent with view that LL-37 plays a key role in defense against bacterial pathogens and that elevated expression of LL-37 enhances the protection against infective threats [19,20,21,22,23]. Furthermore, low baseline plasma levels of the antimicrobial peptide hCAP18, the precursor of LL-37, in patients undergoing hemodialysis has been found to be associated with an increased risk of death attributable to infection [24].…”

Section: Discussionsupporting

confidence: 90%

Circulating cathelicidin LL-37 in adult patients with pulmonary infectious diseases

Majewski

Żelechowska

Brzezińska‐Błaszczyk

2017

CIM

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Purpose: The antimicrobial peptide cathelicidin LL-37 plays a role in the immune response in the course of lung infections; however, the exact role of LL-37 in defense mechanisms against bacteria within the respiratory tract is has not been precisely described. The aim of our study was to evaluate LL-37 concentrations in the serum of pulmonary tuberculosis (TB) patients, patients with pneumonia caused by Gram-positive and Gram-negative bacteria and to compare them with those of healthy subjects.Methods: Thirty TB patients, 30 patients with pneumonia caused by Gram-positive bacteria, 30 patients with pneumonia caused by Gram-negative bacteria, and 30 healthy control subjects were enrolled in the study. Serum LL-37 concentration was measured using an enzyme-linked immunosorbent assay (ELISA). Results:The mean (± SEM) LL-37 concentration in patients with TB (13.94±5.13 ng/mL) was significantly higher than that in patients with Gram-positive bacteria-induced pneumonia (7.87±4.58 ng/mL, P=0.00077), in patients with Gram-negative bacteria-induced pneumonia (10.27±3.60 ng/mL, P=0.00730), and in control healthy subjects (1.75±0.71 ng/mL, P=0.00004). Conclusion:Our data suggest that cathelicidin LL-37 is an important element of host defense in the course of bacterial diseases within the respiratory tract, particularly when the infection is caused by an intracellular pathogen.

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“…moreover, Helicobacter pylori infection in gastroduodenal diseases induce HNPs release [4][5][6]. On the contrary, plasma concentrations and gene expression levels of HNP1-3 were elevated in patients with pulmonary tuberculosis [7,8]. Recently, findings indicated that HNPs and neutrophils might also play a role in immunopathogenesis of endometriosis [9].…”

Section: Introductionmentioning

confidence: 99%