Differential expression of calbindin and calretinin in the human fetal amygdala

Setzer, Matthias; Ulfig, Norbert

doi:10.1002/(sici)1097-0029(19990701)46:1<1::aid-jemt1>3.0.co;2-p

Cited by 25 publications

(11 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The superficial nuclei and central nucleus show evidence of synaptogenesis in the fifth month, potentially due to early connections with the brainstem, whereas the deep nuclei do not show evidence of synaptogenesis until the seventh month possibly due to the strong interconnectivity with association areas in the neocortex that also develop later (Ulfig, Setzer, & Bohl, 1999, 2003). In the sixth and seventh month of fetal development, the columns lose contact with the ganglionic eminence and cellular differentiation and reorganization takes place (Setzer & Ulfig, 1999). In the eighth month of human gestation, migration has essentially ended and the cytoarchitecture closely resembles that of the mature amygdala (Humphrey, 1972; Setzer & Ulfig, 1999; Ulfig, et al, 1998, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…In the sixth and seventh month of fetal development, the columns lose contact with the ganglionic eminence and cellular differentiation and reorganization takes place (Setzer & Ulfig, 1999). In the eighth month of human gestation, migration has essentially ended and the cytoarchitecture closely resembles that of the mature amygdala (Humphrey, 1972; Setzer & Ulfig, 1999; Ulfig, et al, 1998, 2003). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders

2011

View full text Add to dashboard Cite

The amygdala, perhaps more than any other brain region, has been implicated in numerous neuropsychiatric and neurodevelopmental disorders. It is part of a system initially evolved to detect dangers in the environment and modulate subsequent responses, which can profoundly influence human behavior. If its threshold is set too low, normally benign aspects of the environment are perceived as dangers, interactions are limited, and anxiety may arise. If set too high, risk taking increases and inappropriate sociality may occur. Given that many neurodevelopmental disorders involve too little or too much anxiety or too little of too much social interaction, it is not surprising that the amygdala has been implicated in many of them. In this chapter, we begin by providing a brief overview of the phylogeny, ontogeny, and function of the amygdala and then appraise data from neurodevelopmental disorders which suggest amygdala dysregulation. We focus on neurodevelopmental disorders where there is evidence of amygdala dysregulation from postmortem studies, structural MRI analyses or functional MRI. However, the results are often disparate and it is not totally clear whether this is due to inherent heterogeneity or differences in methodology. Nonetheless, the amygdala is a common site for neuropathology in neurodevelopmental disorders and is therefore a potential target for therapeutics to alleviate associated symptoms.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders

2011

View full text Add to dashboard Cite

show abstract

“…It is important to note that, in the rat basolateral complex, CB can be involved in the regulation of intracellular calcium during cell migration and differentiation (Berdel and Morys2 000). Moreover, CB may be involved in the regulation of neuronal migration during early human fetal amygdala development (Setzer and Ulfig 1999).…”

Section: Introductionmentioning

confidence: 99%

Distribution of calbindin-D28k, neuronal nitric oxide synthase, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) in the lateral nucleus of the sheep amygdaloid complex

et al. 2006

View full text Add to dashboard Cite

This study describes calbindin-D28k (CB), neuronal nitric oxide synthase (nNOS), and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) expression in the lateral nucleus of the sheep amygdaloid complex. Double immunofluorescence protocol was used in order to determine whether there is colocalization of CB and nNOS. The CB-immunoreactive (IR) neuronal population was composed especially of non-pyramidal neurons, but a few pyramidal cells were also present. The non-pyramidal neurons showed a multipolar and, occasionally, a fusiform morphology. The comparison between single-labeled CB-IR non-pyramidal neurons and cells belonging to CB-IR neuronal population showed they were identical for morphology, mean size, and distribution. The single-labeled CB-IR non-pyramidal neurons were only the 17.8% of the total non-pyramidal neurons counted. The nNOS-IR neuronal population was represented by non-pyramidal multipolar and fusiform neurons. Single-labeled nNOS-IR non-pyramidal neurons had the same morphology, mean area, and distribution as cells belonging to nNOS-IR neuronal population. Single-labeled nNOS-IR non-pyramidal neurons were more numerous than single-labeled CB-IR, and represented the 73.7% of total non-pyramidal neurons counted. NADPH-d-positive cells had the same morphology and distribution as the nNOS-IR neurons. Double immunolabeling (CB/nNOS) was found mostly in non-pyramidal multipolar neurons and only in a few non-pyramidal fusiform cells. These neurons had a mean perikaryal area significantly higher and significantly smaller than that of single-labeled nNOS and single-labeled CB-IR non-pyramidal neurons, respectively. CB and nNOS coexist only in a minority of non-pyramidal neurons (8.5%). The 32.4% of all CB-IR non-pyramidal neurons were nNOS-positive; only 10.4% of nNOS-IR non-pyramidal neurons were CB-positive. These results indicate that CB and nNOS are expressed by selective neurons and that the majority of nNOS-IR non-pyramidal neurons are lacking in CB.

show abstract

“…Ectopic receptor cells have also been noted in the non-sensory epithelium of the developing VNO of rat and mouse fetuses (Abe et al 1992;Johnson et al 1994;Tarozzo et al 1998), whereas ectopic calretinin immunoreactive receptor cells were not observed in the VNO of adult mammals, also not in T. belangeri (Malz et al 2000). Therefore, in T. belangeri, developing ectopic receptor cells might express calretinin transiently as has also been reported for neurons in the hippocampus (Jiang and Swann 1997) and the amygdala (Setzer and Ulfig 1999). These calretinin immunoreactive ectopic receptor cells, in T. belangeri, might undergo apoptosis, as has been suggested by Tarozzo et al (1998) for transiently OMP labeled ectopic receptor cells in the non-sensory epithelium of prenatal stages of laboratory mice.…”

Section: Discussionmentioning

confidence: 99%

Calretinin immunoreactivity in the prenatally developing olfactory systems of the tree shrew Tupaia belangeri

2002

View full text Add to dashboard Cite

The prenatal patterns of calretinin immunoreactivity were studied in the olfactory systems of Tupaia belangeri. We investigated the peripheral and primary central parts of the vomeronasal system and of the main olfactory system from the 19th to the 43rd (last) day of gestation and compared the findings with the known calretinin immunoreactivity patterns in adult T. belangeri and the published data on other mammals. The onset of calretinin immunoreactivity was noted in the main olfactory system on the 23rd day of gestation and, in the vomeronasal system, on the 25th day of gestation: single precursors of receptor cells with calretinin immunoreactive perikarya and processes were observed in both epithelia. Their neuronal identity was proven by olfactory marker protein immunoreactivity. On the 42nd day of gestation, almost all receptor cells and nerve fibers, many interneurons and projecting cells were calretinin immunoreactive in the main olfactory and in the vomeronasal systems. In contrast to the intensive calretinin labeling previously observed in virtually all vomeronasal epithelial cells of adult T. belangeri, among developing receptor cells a population of intensively labeled, basally located perikarya was distinguishable from a population of less intensively stained, more apically located ones. In the main olfactory epithelium of fetal T. belangeri, calretinin immunoreactive receptor cells occurred in the middle layers. Whereas in the vomeronasal sensory epithelium differently reacting layers of receptor cells might represent the two known subfamilies of receptor cells, in the main olfactory epithelium the differing calretinin expression in the layers of the epithelium, most probably, did not reflect known subfamilies of odour receptor cells. Transiently, ectopic calretinin immunoreactive receptor cells were observed in the future non-sensory epithelium of the vomeronasal organ.

show abstract

Differential expression of calbindin and calretinin in the human fetal amygdala

Cited by 25 publications

References 52 publications

Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders

Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders

Distribution of calbindin-D28k, neuronal nitric oxide synthase, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) in the lateral nucleus of the sheep amygdaloid complex

Calretinin immunoreactivity in the prenatally developing olfactory systems of the tree shrew Tupaia belangeri

Contact Info

Product

Resources

About