Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction

Luchner, Andreas; Muders, Frank; Dietl, O.; Friedrich, Erik B.; Blumberg, Friedrich C.; Protter, Andrew A.; Riegger, Günter A.J.; Elsner, Dietmar

doi:10.1016/s0008-6363(01)00316-9

Cited by 54 publications

(37 citation statements)

References 35 publications

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“…This notion corroborates previous studies (3,25) in rabbit hearts showing the superiority of BNP in diagnosing overload-induced LV dysfunction. Comparable conclusions were drawn in studies 6.…”

Section: Stretch-induced Cardiomyocyte Hypertrophysupporting

confidence: 92%

Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes

Blaauw

Nieuwenhoven

Willemsen

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Stretch-induced Cardiomyocyte Hypertrophysupporting

confidence: 92%

Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes

Blaauw

Nieuwenhoven

Willemsen

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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“…The differential levels of ANF and BNP between the cardiac compartments are similar to those noted by investigators using TIC in rabbits. 19 Paced TG and NTG rabbits had significant decreases in atrial SERCA and PLN RNA compared with nonpaced NTG rabbits, but transcript levels were not significantly downregulated in the ventricles.…”

Section: Resultsmentioning

confidence: 84%

Forced Expression of α-Myosin Heavy Chain in the Rabbit Ventricle Results in Cardioprotection Under Cardiomyopathic Conditions

et al. 2005

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Background-The biochemical differences between the 2 mammalian cardiac myosin heavy chains (MHCs), ␣-MHC and ␤-MHC, are well described, but the physiological consequences of basal isoform expression and isoform shifts in response to altered cardiac load are not clearly understood. Mature human ventricle contains primarily the ␤-MHC isoform. However, the ␣-MHC isoform can be detected in healthy human ventricle and appears to be significantly downregulated in failing hearts. The unique biochemical properties of the ␣-MHC isoform might offer functional advantages in a failing heart that is expressing only the ␤-MHC isoform. This hypothesis cannot be tested in mice or rats because both species express ␣-MHC as the predominant isoform. Methods and Results-To test the effects of persistent ␣-MHC expression on the background of ␤-MHC, we made transgenic (TG) rabbits that expressed rabbit ␣-MHC cDNA in the ventricle so that the endogenous myosin was partially replaced by the transgenically encoded species. Molecular, histological, and functional analyses showed no significant baseline effects in the TG rabbits compared with nontransgenic (NTG) littermates. To determine whether ␣-MHC expression afforded any advantages to stressed myocardium, a cohort of TG and NTG rabbits was subjected to rapid ventricular pacing. Although both the TG and NTG rabbits developed dilated cardiomyopathy, the TG rabbits had a higher shortening fraction, less septal thinning, and more normal ϮdP/dt than paced NTG rabbits. Conclusions-Transgenic expression of ␣-MHC does not have any apparent detrimental effects under basal conditions and is cardioprotective in experimental tachycardia-induced cardiomyopathy.

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“…10 The increased production of BNP in heart failure would appear to be secondary to induced ventricular production. 21 The coronary sinus also drains the lateral and posterior left atrium and the left atrial appendage, 22 and these areas of the left atrium drained by the coronary sinus may be responsible for elevated levels of BNP observed.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Cardiac Brain Natriuretic Peptide Release in Patients With Paroxysmal Atrial Fibrillation Undergoing Left Atrial Ablation

Gould

Gula

Bhayana

et al. 2010

Circ: Arrhythmia and Electrophysiology

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Background-Paroxysmal atrial fibrillation (PAF) is associated with elevated levels of brain natriuretic peptide (BNP).The exact cardiac source and implications of this are currently unknown, as are the effects of left atrial ablation on cardiac BNP release. We sought to investigate BNP levels at different cardiac sites in PAF patients before and after left atrial ablation and compare these with a non-atrial fibrillation control cohort. Methods and Results-Twenty PAF patients (52Ϯ10 years, 70% men; left ventricular ejection fraction, 55Ϯ3%) undergoing ablation were studied, BNP levels were measured at different cardiac sites before and after ablation and compared with a control cohort undergoing ablation for left lateral accessory pathways (10 patients, 41Ϯ11 years; left ventricular ejection fraction, 55Ϯ4%). In both cohorts, the coronary sinus BNP levels were the greatest. The PAF cohort had significantly greater BNP levels than the control cohort at all sites before and after ablation. Ablation of the left atrium was associated with a significant decrease in coronary sinus BNP levels (Pϭ0.05) and transcardiac BNP gradient (Pϭ0.03). This was not observed in the control cohort. Conclusions-BNP levels are elevated in PAF, with the highest levels in the coronary sinus. Ablation of the left atrium was associated with an immediate decrease of BNP levels, implicating this as the source. (Circ Arrhythm Electrophysiol. 2010;3:18-23.)

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Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction

Abstract: The current studies demonstrate differential activation of atrial and LV ANP and BNP under normal conditions and during the progression to heart failure and provide a molecular basis for the superiority of BNP as marker of LV dysfunction and CHF.

Cited by 54 publications

References 35 publications

Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes

Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes

Forced Expression of α-Myosin Heavy Chain in the Rabbit Ventricle Results in Cardioprotection Under Cardiomyopathic Conditions

Characterization of Cardiac Brain Natriuretic Peptide Release in Patients With Paroxysmal Atrial Fibrillation Undergoing Left Atrial Ablation

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