Differential expression of death receptors, their ligands and adaptors as molecular signatures of neuropathologies in a mouse model of prion disease
Ranjit Kumar Giri
Abstract:Background
Prion diseases are transmissible and fatal neurodegenerative diseases characterized by accumulation of a misfolded form of a host-encoded protein (PrPSc), astrocytosis, microgliosis, spongiosis, and extensive neuron loss. Elevated levels of cell membrane associated PrPSc protein and inflammatory cytokines hint towards the activation of death receptor (DR) pathway/s in prion diseases. However, it is unclear whether prion disease is associated with the alteration of all major death receptors, their l… Show more
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