Differential Expression of EB-Viral and Cellular Surface Markers on Burkitt Lymphoma and Lymphoblastoid Cell Lines

Epstein-Barr Virus and Its Interaction with the Host

“…It has been shown that BL cells either do not produce LMP or at most in a truncated form [Modrow and Wolf, 1986]; in addition, certain peripheral blood cells have been identified, which do not ex press LMP. Furthermore, even in cell lines known to express LMP, only less than 10% of cells show a high level of LMP expression, the rest expresses LMP at most to a much lesser extent [Modrow and Wolf, 1986;Modrow et al, 1987], It has been shown by several groups that absence of LMP would allow such cells to escape specific killing [Jilg et al, 1988Thorley-Lawson and Israelsohn, 1987]. Other latent gene products are either absent or, in the case of EBNA1, have a high homology to a cel lular gene and are not targets for T-cell-mediated cell lysis.…”

Qualitative and quantitative differences between Burkitt lymphoma and lymphoblastoid cell lines in the expression of membrane ecto‐nucleotidases and in the response to agonists of the A2‐type adenosine receptor

“…However, a more detailed study of such differences at the molecular level has only recently become possible. This was achieved by using panels of specific monoclonal antibodies , by studying differential sensitivity to MHC-restricted T-cell cytotoxicity Torsteinsdottir et al, 1986) or by performing direct qualitative and quantitative analysis of surface components coded either by the viral (LYDMA or BNLF 1-MA) or the cellular genomes (MHC-products) (Modrow and Wolf, 1986;Modrow et al, 1987).…”