Differential expression of estrogen receptor alpha in the embryonic adrenal–kidney–gonadal complex of the oviparous lizard, Calotes versicolor (Daud.)

Inamdar, Laxmi S.; Khodnapur, B S; Nindi, Robert S.; Seshagiri, Polani B.

doi:10.1016/j.ygcen.2014.08.003

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…For example, transcriptome analysis revealed that genes involved in steroid enzyme synthesis and brain development were sexually dimorphic expressed prior to TSP in T. scripta [Czerwinski et al, 2016], similar to what is observed for Sf1 , Wt1 , and Dax1 involved in gonadal development in C. picta [Valenzuela et al, 2006;Valenzuela, 2008a, b], and it also revealed that Cirbp (cold-inducible RNAbinding protein) is involved in sex determination in C. serpentina [Schroeder et al, 2016]. But there are few studies on the molecular networks of TSD reptiles in other regions such as Asia [Hoshi and Nakao, 2008;Inamdar et al, 2015]. Thus, molecular studies across TSD reptiles representing other turtle families, reptilian lineages, and geographic regions are overdue and necessary if we are to fully understand the evolution of TSD.…”

supporting

confidence: 61%

Effects of Incubation Temperature on the Expression of Sex-Related Genes in the Chinese Pond Turtle, Mauremys reevesii

Tang

Mu²,

Valenzuela³

et al. 2017

Sex Dev

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Despite widespread temperature-dependent sex determination (TSD) in reptiles, it is still unclear how the molecular network responds to temperature variation and drives the sexual fate. Profiling of sex-related genes is the first step in understanding the sex determination system in reptiles. In this study, we cloned the full-length coding sequences of Cyp19a1, Foxl2, Rspo1, Sf1, and Sox9 in an Asian freshwater turtle (Mauremys reevesii) with TSD and identified the expression patterns of these genes and Dmrt1 at different incubation temperatures to understand their roles in urogenital development. Our results showed that Cyp19a1, Foxl2, and Rspo1 were expressed in the adrenal-kidney-gonadal complex at a high level in females, while Sf1 and Dmrt1 were highly expressed in males. In addition, Foxl2 and Rspo1 showed sex-dimorphic expression in the presumed early thermosensitive period (TSP), Dmrt1 was upregulated at the beginning of the presumed TSP, and Sox9 did not show sex-dimorphic expression until the end of the presumed TSP. These results suggest that Foxl2 and Rspo1 are probably upstream genes involved in female sex determination and that Dmrt1 may be a key factor in male sex determination. Therefore, our study provides a solid foundation for further investigations on the molecular mechanism underlying sex determination in M. reevesii.

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supporting

confidence: 61%

Effects of Incubation Temperature on the Expression of Sex-Related Genes in the Chinese Pond Turtle, Mauremys reevesii

Tang

Mu²,

Valenzuela³

et al. 2017

Sex Dev

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“…Although previous studies have reported the presence of sex steroid receptors in diverse tissues on lizards (Young et al, 1994;Beck and Wade, 2009;Verderame and Limatola, 2010;Hammouche et al, 2012;Inamdar et al, 2015;Yatsu et al, 2016), there is limited information available on this group. as their expression was mainly cytosolic, further studies must consider signalling via non-genomic mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…These receptors were reported in many lizard species such as Bradypodion pumilum, Plestiodon finitimus, Gekko japinicus (Yatsu et al, 2016), and Hemodactylus flaviviridis (Tripathy and Rai, 2017). At least one receptor has been detected in Podarcis sicula (Verderame and Limatola, 2010), Anolis carolinensis (Beck and Wade, 2009), and Calotes versicolor (Inamdar et al, 2015). In P. sicula, ERα is involved in vitellogenesis (Verderame and Limatola, 2010), while in H. flaviviridis, it enhances aromatase activity via gonadotropin hormones (Tripathy and Rai, 2017).…”

Section: Introductionmentioning

confidence: 98%

Sex steroid receptors in the ovarian follicles of the lizard Sceloporus torquatus

Cruz-Cano

Sánchez-Rivera

Álvarez-Rodríguez

et al. 2023

Zygote

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Summary Estradiol and progesterone have been recognized as important mediators of reproductive events in the female mainly via binding to their receptors. This study aimed to characterize the immunolocalization of the estrogen receptor alfa (ERα), estrogen receptor beta (ERβ) and progesterone receptor (PR) in the ovarian follicles of the lizard Sceloporus torquatus. The localization of steroid receptors has a spatio-temporal pattern that depends on the stage of follicular development. The immunostaining intensity of the three receptors was high in the pyriform cells and the cortex of the oocyte of previtellogenic follicles. During the vitellogenic phase, the granulosa and theca immunostaining was intense even with the modification of the follicular layer. In the preovulatory follicles, the receptors were found in yolk and additionally, ERα was also located in the theca. These observations suggest a role for sex steroids in regulating follicular development in lizards, like other vertebrates.

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“…It is conceivable that the sexual dimorphism observed in the prevalence, course, and severity of many common diseases, including cardiovascular diseases, autoimmune diseases, and asthma, may originate from a sex-specific genetic architecture that is created in the course of development (also through ER activity) and that results in a male and female differential endocrine susceptibility and gene regulation, particularly in sex steroid responsive genes. The relevance of oestrogen programming mechanisms within the mammalian foetus and perinatal time period is underlined by studies on liver metabolism that are strictly regulated by sex and where the expression and activation of hepatic ER in the course of embryo maturation and in adult life plays a prominent role (Della Torre et al, 2018) on energy metabolism (Maniu et al 2016; Yuchi et al 2015), gastric functions (Campbell-Thompson et al 2001), adrenal and renal activity (Inamdar, et al 2015; Walker, et al 2009), cardiovascular activity (Del Principe et al 2015), and immune functions (Zoller and Kersh 2006).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional activity of oestrogen receptors in the course of embryo development

Torre

Rando

Meda

et al. 2018

Journal of Endocrinology

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Oestrogens are well-known proliferation and differentiation factors that play an essential role in the correct development of sex-related organs and behaviour in mammals. With the use of the ERE-Luc reporter mouse model, we show herein that throughout mouse development, oestrogen receptors (ERs) are active starting from day 12 post conception. Most interestingly, we show that prenatal luciferase expression in each organ is proportionally different in relation to the germ layer of the origin. The luciferase content is highest in ectoderm-derived organs (such as brain and skin) and is lowest in endoderm-derived organs (such as liver, lung, thymus and intestine). Consistent with the testosterone surge occurring in male mice at the end of pregnancy, in the first 2 days after birth, we observed a significant increase in the luciferase content in several organs, including the liver, bone, gonads and hindbrain. The results of the present study show a widespread transcriptional activity of ERs in developing embryos, pointing to the potential contribution of these receptors in the development of non-reproductive as well as reproductive organs. Consequently, the findings reported here might be relevant in explaining the significant differences in male and female physiopathology reported by a growing number of studies and may underline the necessity for more systematic analyses aimed at the identification of the prenatal effects of drugs interfering with ER signalling, such as aromatase inhibitors or endocrine disrupter chemicals.

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Differential expression of estrogen receptor alpha in the embryonic adrenal–kidney–gonadal complex of the oviparous lizard, Calotes versicolor (Daud.)

Cited by 9 publications

References 44 publications

Effects of Incubation Temperature on the Expression of Sex-Related Genes in the Chinese Pond Turtle, <b><i>Mauremys reevesii</i></b>

Effects of Incubation Temperature on the Expression of Sex-Related Genes in the Chinese Pond Turtle, <b><i>Mauremys reevesii</i></b>

Sex steroid receptors in the ovarian follicles of the lizard Sceloporus torquatus

Transcriptional activity of oestrogen receptors in the course of embryo development

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