Differential expression of factors involved in fat metabolism with age and the menopause transition

Misso, Marie; Jang, Choon‐Gon; Adams, Jennifer R.; Tran, Jane; Murata, Yoko; Bell, Robin Jean; Boon, Wah Chin; Simpson, Evan R.; Davis, Susan Ruth

doi:10.1016/j.maturitas.2004.08.013

Cited by 57 publications

(36 citation statements)

References 23 publications

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“…Other factors involved in fat metabolism are also likely to be involved. Using real-time PCR analysis, Misso et al (2005) (Dallongeville et al, 1995;Poehlman et al, 1995;Lynch et al, 2001). However, data from all studies using the euglycemic-hyperinsulinemic clamp technique, strongly suggest that aging and central obesity make a major contribution to the development of IR in women after menopause (DeNino et al, 2001;Guthrie et al, 2001).…”

Section: Menopause Hormonal Changes and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

136

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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Section: Menopause Hormonal Changes and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

136

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“…Many studies on estrogens and estrogenic compounds indicate that they have a major impact on the metabolism of lipids (Misso, et al, 2005b), but also on elements of the metabolic syndrome e.g. leptin function.…”

Section: Estrogen Estrogen Estrogen Estrogen Estrogenmentioning

confidence: 99%

“…It was shown that adipose tissue is able to produce increasing levels of estrogen with age at the time of menopause (Misso, et al, 2005a). The parallel increased levels of expression of adiponectin in the gluteal fat might lead to enhanced insulin sensitivity, which could be a physiological prevention of decreasing insulin sensitivity by estrogen depletion (Greenfield, et al, 2003, Misso, et al, 2005b. The well-known phytoestrogen genistein shows antiadipogenic effects by inhibiting the proliferation of adipocytes (Harmon and Harp, 2001) and promotes lipolysis (Szkudelski, et al, 2005).…”

Section: Estrogen Estrogen Estrogen Estrogen Estrogenmentioning

confidence: 99%

Is there an estrogenic component in the metabolic syndrome?

Starcke

Vollmer

2006

Genes Nutr

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“…Negative metabolic changes promoted by menopause, such as increased systemic inflammation and increased insulinemia are factors that stimulate adipogenesis and inhibit lipolysis [9][10][11] and have been identified as factors that make it difficult to lose weight when induced by physical training 12 . However, in previous studies, greater weight loss may occur in people with higher initial body mass 13,14 , which may be the case for MN women in relation to OS.…”

Section: Introductionmentioning

confidence: 99%

Influence of menopause on body fat induced by aerobic training

Cardoso

Silva

Sena

et al. 2018

Motriz: rev. educ. fis.

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-Aims: to compare the influence of menopause on body fat, induced by a physical training program. Methods: Twenty-one sedentary women, 10 postmenopausal (MN; 54.6 ± 5.1 years, 42.9 ± 4.1 % body fat) and 11 in the ovulatory state (OS; 35.1 ± 5.4 years, 44.1 ± 5.5 % body fat), performed a training program with aerobic exercise (12 weeks, five times / week, 60 minutes per session). Before and after this program, the following measurements were taken: sum of skin fold (∑D), body fat percentage (%F), waist-hip ratio (WHR) and abdominal circumference (AC). Results: MN and OS significantly reduced ΣD (38.5 ± 25.1 mm and 27.7 ± 19.4 mm, respectively), but without differences between the groups. MN group women obtained relative reduction in the suprailiac fold, significantly greater than OS (25 ± 10 vs. 11.5 ± 12 mm), and also a greater reduction in the %F (13.5 ± 8% vs. 6.6 ± 6%). There were very slight reductions in WHR in both groups (0.009 ± 0.02 and 0.005 ± 0.03 in MN and OS, respectively), as well as AC (reduction of 3.5 ± 3 cm and 3.9 ± 2.9 cm for MN and OS), with no differences between groups. Conclusion: The postmenopausal women responded to a training program with a greater reduction of body fat, but in only one of four evaluated body composition variables.

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Differential expression of factors involved in fat metabolism with age and the menopause transition

Cited by 57 publications

References 23 publications

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Is there an estrogenic component in the metabolic syndrome?

Influence of menopause on body fat induced by aerobic training

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